FRI0035 Risk factors for clinically important upper gi events: the vigour study

Bombardier, Claire; Laine, Loren; Reicin, AS; Shapiro,; Sperling, RS

doi:10.1136/annrheumdis-2001.1164

Cited by 3 publications

(4 citation statements)

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“…The Vioxx Gastrointestinal Outcomes Research (VIGOR) study -a prospective, randomized study (vide infra) -allowed for the calculation of relative and absolute risk (7); age and previous gastrointestinal history were confirmed to be significant risk factors. In patients taking naproxen, the absolute annual risk of having a clinically important gastrointestinal event was 19% for those with a previous gastrointestinal complication and 14% for those older than 75 years of age (22).…”

Section: Mortalitymentioning

confidence: 99%

“…An analysis of various risk factors in the VIGOR trial indicated a risk reduction of 88% in the low-risk subgroup, 51% in the high-risk subgroup and 54% in the intermediate-risk subgroup. The risk factors that were significantly associated with gastrointestinal events included age, prior history of clinical gastrointestinal events (complicated or uncomplicated), disease severity, duration of disease, prior history of gastrointestinal symptoms, and prior use of low dose H 2 RAs, steroids or NSAIDs (7,22).…”

Section: Risk Reductionmentioning

confidence: 99%

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Recommendations for the Appropriate Use of Anti-Inflammatory Drugs in the Era of the Coxibs: Defining the Role of Gastroprotective Agents

Hunt

Barkun

Baron

et al. 2002

Canadian Journal of Gastroenterology

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Treatment with anti-inflammatory drugs and the analgesic efficacy of conventional nonsteroidal anti-inflammatory drugs (NSAIDs) are compromised by a two- to fourfold increased risk of gastrointestinal complications. This increased risk has resulted in an increasing use of the new selective cyclooxygenase-2 inhibitors or coxibs, which, in clinical trials and outcomes studies, reduced gastrointestinal adverse events by 50% to 65% compared with conventional NSAIDs. However, the coxibs are not available to all patients who need them, and NSAIDs are still widely used. Moreover, treatment with a coxib cannot heal pre-existing gastrointestinal lesions, and cotherapy with an anti-secretory drug or mucosal protective agent may be required. This paper addresses the management of patients with risk factors for gastrointestinal complications who are taking NSAIDs and makes recommendations for the appropriate use of 'gastroprotective' agents (GPAs) in patients who need to take an NSAID or a coxib. When economically possible, a coxib alone is preferable to a conventional NSAID plus a GPA to minimize exposure to potential gastrointestinal damage and avoid unnecessary dual therapy. Patients at high risk require a GPA in addition to a coxib.

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Section: Mortalitymentioning

confidence: 99%

Section: Risk Reductionmentioning

confidence: 99%

Recommendations for the Appropriate Use of Anti-Inflammatory Drugs in the Era of the Coxibs: Defining the Role of Gastroprotective Agents

Hunt

Barkun

Baron

et al. 2002

Canadian Journal of Gastroenterology

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“…For examples, the enzyme-triggered release of NSAID ibuprofen from its peptide-conjugate hydrogel was demonstrated by Kim et al 46 Stupp et al, however, converted nabumetone into a hydrogel by conjugating with hydarzone containing peptide amphiphile and studied its release at physiological pH. 47 Among the NSAIDs, naproxen (one of the oldest and best-selling prescription drugs also known for its milder cardiovascular effects with a possible cardio-protective role in humans 48 ) has been relatively less explored in this context. Xu and Yang showed that naproxen can be released from a hydrogel made from diselenide containing polymer and naproxen-based peptide amphiphile by UV radiation.…”

Section: ■ Introductionmentioning

confidence: 99%

β-Amino Acid and Amino-Alcohol Conjugation of a Nonsteroidal Anti-Inflammatory Drug (NSAID) Imparts Hydrogelation Displaying Remarkable Biostability, Biocompatibility, and Anti-Inflammatory Properties

et al. 2013

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A well-known nonsteroidal anti-inflammatory drug (NSAID), namely, naproxen (Np), was conjugated with β-alanine and various combinations of amino alcohols and l-alanine. Quite a few bioconjugates, thus synthesized, were capable of gelling pure water, NaCl solution (0.9 wt %), and phosphate-buffered saline (PBS) (pH 7.4). The hydrogels were characterized by rheology and electron microscopy. Hydrogelation was probed by FT-IR and temperature-variable (1)H NMR studies. Single-crystal X-ray diffraction (SXRD) of a nonhydrogelator and a hydrogelator in the series established a useful structure-property (gelation) correlation. MTT assay of the hydrogelators in the mouse macrophage RAW 264.7 cell line showed excellent biocompatibility. The prostaglandin E2 (PGE2) assay of the hydrogelators revealed their anti-inflammatory response, which was comparable to that of the parent NSAID naproxen sodium (Ns).

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“…Noteworthy is the fact that the styrenylsubstituted butenolide product 5a may be viewed as a vinylogous congener of rofecoxib, a widely used nonsteroidal anti-inflammatory drug that was withdrawn from the market. 15 Recently, Ramachandran's group reported a catalyst-free tandem amination−lactonization reaction for the synthesis of α-aminomethyl lactones with excellent yields and diastereoselectivities. 16 Inspired by this elegant work, further efforts were devoted to carrying out the tandem ring-opening/lactonization directly initiated by the Michael addition of a secondary amine or other nitrogen nucleophiles to vinyl epoxide 3 (Scheme 2).…”

mentioning

confidence: 99%

Reagent-Controlled Tandem Reactions of Vinyl Epoxides: Access to Functionalized γ-Butenolides

Zhang

Kong

et al. 2016

Org. Lett.

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A new approach to functionalized γ-butenolides based on reagent-controlled tandem reaction sequences of Morita-Baylis-Hillman-type vinyl epoxides is described. The nucleophilic addition of a tertiary phosphine to the electron-deficient alkene led to ring-opening of the epoxide followed by lactonization to produce phosphonium ylides, which could undergo Wittig olefination with aryl trifluoromethyl ketones and aryl aldehydes to give 3-alkenyl γ-butenolides in moderate to good yields and high E/Z selectivity. Tertiary amine promoted the Michael-type addition of carbon- and nitrogen-based nucleophiles to the vinyl epoxides followed by lactonization to provide diverse 3-substituted γ-butenolides.

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FRI0035 Risk factors for clinically important upper gi events: the vigour study

Cited by 3 publications

References 0 publications

Recommendations for the Appropriate Use of Anti-Inflammatory Drugs in the Era of the Coxibs: Defining the Role of Gastroprotective Agents

Recommendations for the Appropriate Use of Anti-Inflammatory Drugs in the Era of the Coxibs: Defining the Role of Gastroprotective Agents

β-Amino Acid and Amino-Alcohol Conjugation of a Nonsteroidal Anti-Inflammatory Drug (NSAID) Imparts Hydrogelation Displaying Remarkable Biostability, Biocompatibility, and Anti-Inflammatory Properties

Reagent-Controlled Tandem Reactions of Vinyl Epoxides: Access to Functionalized γ-Butenolides

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