Abstract:BackgroundABCB1 (P-gp) and ABCG2 (BCRP1) are part of the adenine triphosphate (ATP)-binding cassette (ABC) transporter proteins. These proteins mediate efflux of drugs from inside the cells and can confer a multidrug resistance phenotype. Drugs included among its substrates are indicated in RA patients. Accordingly, an association between disease activity and ABCB1 and ABCG2 function might be hypothesized.ObjectivesThe study was undertaken to compare the drug efflux function of both transporters in patients wi… Show more
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