Freud's Project and its diagram: anticipating the Hebbian synapse

Schott, G D

doi:10.1136/jnnp.2010.220400

Cited by 7 publications

(6 citation statements)

References 24 publications

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“…Although changes in synaptic connections, broadly referred to as synaptic plasticity, represent only one of multiple neuronal plasticity processes [which include, among others, changes in neuronal excitability, adult neurogenesis, and large scale changes in cortical maps (Giese and Mizuno, 2013)], synaptic plasticity has received the most attention. This attention is justified by the functional potency and enormous flexibility offered by changes at these strategic locations, ideas that can be traced back to the writings of James, Cajal, Freud, and most influentially, Hebb (Berlucchi and Buchtel, 2009; Schott, 2011). …”

Section: Introductionmentioning

confidence: 99%

The roles of protein expression in synaptic plasticity and memory consolidation

Rosenberg¹,

Gal-Ben-Ari²,

Dieterich³

et al. 2014

Front. Mol. Neurosci.

136

103

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The amount and availability of proteins are regulated by their synthesis, degradation, and transport. These processes can specifically, locally, and temporally regulate a protein or a population of proteins, thus affecting numerous biological processes in health and disease states. Accordingly, malfunction in the processes of protein turnover and localization underlies different neuronal diseases. However, as early as a century ago, it was recognized that there is a specific need for normal macromolecular synthesis in a specific fragment of the learning process, memory consolidation, which takes place minutes to hours following acquisition. Memory consolidation is the process by which fragile short-term memory is converted into stable long-term memory. It is accepted today that synaptic plasticity is a cellular mechanism of learning and memory processes. Interestingly, similar molecular mechanisms subserve both memory and synaptic plasticity consolidation. In this review, we survey the current view on the connection between memory consolidation processes and proteostasis, i.e., maintaining the protein contents at the neuron and the synapse. In addition, we describe the technical obstacles and possible new methods to determine neuronal proteostasis of synaptic function and better explain the process of memory and synaptic plasticity consolidation.

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Section: Introductionmentioning

confidence: 99%

The roles of protein expression in synaptic plasticity and memory consolidation

Rosenberg¹,

Gal-Ben-Ari²,

Dieterich³

et al. 2014

Front. Mol. Neurosci.

136

103

View full text Add to dashboard Cite

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“…([134], page 127). It has been suggested that in addition to anticipating a Hebb-like synapse, Freud also anticipated the discovery of LTP [31,165]. At about the same time as Hebb, Konorski [106] published his theory of synaptic plasticity underlying learning [13].…”

Section: The Hebb Synapsementioning

confidence: 99%

“…He was also concerned with "the innate processes of instinct that are thought to take the place of learning" (page 140). With respect to innate or hereditary factors, Hebb ([77], pages [165][166][167][168][169][170] refers to Lashley's [116] paper on the experimental analysis of instinct, to Beach's [10] studies of instinct and learning in rats and to Tinbergen's [182] paper on the objective study of innate behaviour. Hebb's view was that it was important to distinguish innate from learned behaviour, however, he pointed out that "there is presumably no mammalian behavior that is uninfluenced either by learning or by the constitution that makes some learning easy or inevitable."…”

Section: The Relationship Of Instinct To Learningmentioning

confidence: 99%

Donald O. Hebb and the Organization of Behavior: 17 years in the writing

Brown

2020

Mol Brain

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The Organization of Behavior has played a significant part in the development of behavioural neuroscience for the last 70 years. This book introduced the concepts of the "Hebb synapse", the "Hebbian cell assembly" and the "Phase sequence". The most frequently cited of these is the Hebb synapse, but the cell assembly may be Hebb's most important contribution. Even after 70 years, Hebb's theory is still relevant because it is a general framework for relating behavior to synaptic organization through the development of neural networks. The Organization of Behavior was Hebb's 40th publication. His first published papers in 1937 were on the innate organization of the visual system and he first used the phrase "the organization of behavior" in 1938. However, Hebb wrote a number of unpublished papers between 1932 and 1945 in which he developed the ideas published in The Organization of Behavior. Thus, the concept of the neural organization of behavior was central to Hebb's thinking from the beginning of his academic career. But his thinking about the organization of behavior in 1949 was different from what it was between 1932 and 1937. This paper examines Hebb's early ideas on the neural basis of behavior and attempts to trace the rather arduous series of steps through which he developed these ideas into the book that was published as The Organization of Behavior. Using the 1946 typescript and Hebb's correspondence we can see a number of changes made in the book before it was published. Finally, a number of issues arising from the book, and the importance of the book today are discussed.

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“…Whether neurology wants to remember Freud with the title emeritus is perhaps even more problematic; some remain admiring of his neurological insights, for example, his early suggestions on dynamic neural nets 3 4. Others are less sure, at best sceptical of psychoanalytic ideas, at worst critical of a failure of child protection through revision of his original seduction theory, in which he rejected his neurotic patients' descriptions of childhood sexual molestation as infantile fantasies.…”

mentioning

confidence: 99%