Fresh versus elective frozen embryo transfer in IVF/ICSI cycles: a systematic review and meta-analysis of reproductive outcomes

Roque, Matheus; Haahr, Thor; Geber, Selmo; Esteves, Sandro C.; Humaıdan, Peter

doi:10.1093/humupd/dmy033

Cited by 335 publications

(211 citation statements)

References 79 publications

Supporting

Mentioning

198

Contrasting

Unclassified

Order By: Relevance

“…Although one woman with unilateral renal agenesis did not develop pre‐eclampsia, the 75% risk of pre‐eclampsia in women with single kidneys following UTx is higher than the previously reported 35% risk . It could be argued that this may be a consequence of other factors associated with UTx, such as in vitro fertilisation, embryo cryopreservation, immunosuppression, or the transplant of postmenopausal, less elastic uteri . However, the fact that pre‐eclampsia has not developed in recipients with normal kidneys suggests that women with unilateral renal agenesis may be at particularly high risk of pre‐eclampsia.…”

Section: Obstetric Outcomesmentioning

confidence: 77%

Human uterine transplantation: a review of outcomes from the first 45 cases

Jones

Saso

Bracewell‐Milnes

et al. 2019

BJOG

132

195

View full text Add to dashboard Cite

Uterine transplantation restores reproductive anatomy in women with absolute uterine factor infertility and allows the opportunity to conceive, experience gestation, and acquire motherhood. The number of cases being performed is increasing exponentially, with detailed outcomes from 45 cases, including nine live births, now available. In light of the data presented herein, including detailed surgical, immunosuppressive and obstetric outcomes, the feasibility of uterine transplantation is now difficult to refute. However, it is associated with significant risk with more than one-quarter of grafts removed because of complications, and one in ten donors suffering complications requiring surgical repair.Tweetable abstract Uterine transplantation is feasible in women with uterine factor infertility, but is associated with significant risk of complication.

show abstract

Section: Obstetric Outcomesmentioning

confidence: 77%

Human uterine transplantation: a review of outcomes from the first 45 cases

Jones

Saso

Bracewell‐Milnes

et al. 2019

BJOG

132

195

View full text Add to dashboard Cite

show abstract

“…It cannot be ruled out the difference in prognosis of the study population may contribute to the difference in the rate of cumulative live birth. Additionally, results from different studies are inconsistent, with some reporting that a freeze-only strategy resulted in a similar rate of cumulative live birth compared with a fresh embryo transfer strategy [4,5,8].…”

Section: Study Findingsmentioning

confidence: 99%

The cumulative live birth rate after a freeze-only strategy versus a conventional fresh embryo transfer strategy: a call for more level 1 evidence

Wei

Legro

Chen

2020

BMC Med

View full text Add to dashboard Cite

“…Women aged ≥ 40 years old, women with previous poor response with no more than 3 oocytes retrieved using a conventional stimulation protocol, and women with abnormal ovarian reserve test with antral follicle number (AFC) < 7 follicles and anti-Mullerian hormone (AMH) < 1.1 ng/ml [3]. 2) Hyper-responders, determined as women with ≥ 15 oocytes to be retrieved [4].…”

Section: Hospital Settings and Patients Inclusionmentioning

confidence: 99%

Defining the Learning Curve is Necessary to Improve Oocyte Retrieval Skills: Lessons from A Single High-Volume Reproductive CenterDefining the Learning Curve is Necessary to Improve Oocyte Retrieval Skills: Lessons from A Single High-Volume Reproductive Center

Cao

You

et al. 2020

Preprint

View full text Add to dashboard Cite

Objective: The objective of this study was to determine the novice trainee’s learning curve for oocytes retrieval procedure through assessment of oocytes retrieval efficiency, operative time and other operative characteristics. Methods: This retrospective cohort study included 200 consecutive patients undergoing transvaginal ultrasound guided oocytes retrieval procedure. Those patients underwent oocyte retrieval procedure by a single operator and one experienced supervisor. Their clinical data, including demographic data, ovarian stimulation cycle information, surgical procedure, and laboratory data were collected over 3 months. CUSUM analyses based on the operative time were performed to determine the learning curve. Results: The mean operative time was 10.10 min. Based on the CUSUM plot of operative time, the learning curve can be divided into three separated phases, phase 1 (case 1 to case 49) was learning phase, phase 2 (case 50 to case 130) was acquisition phase, and phase 3 (case 131 to case 200) was proficiency phase. The operative time was significantly shortened from phase 1 to phase 3 (phase 1, 13.37 ± 4.83min; phase 2, 10.21 ± 3.30 min; phase 3, 7.67 ± 3.24 min, P < 0.001). The oocyte retrieval efficiency was also notably improved from phase 1 to phase 3 (78.2% to 100% based on method 1 to determine oocyte retrieval efficiency, and 104.2% to 121.1% based on method 2 to determine oocyte retrieval efficiency). The retrieved oocytes number, the fertilization rate, clinical pregnancy rate among the three phases showed no significant differences. No patients had severe adverse events. As determined by multiple linear regression, learning phase is the only independent predictor of oocyte retrieval efficiency. Conclusion: Trainees practice transvaginal ultrasound guided oocytes retrieval are expected to achieve a stabilized procedure over consecutive training cases, with acquisition of the skills at 49 cases, and proficiency at 130 cases. Cumulative operative experience can improve the operative time and oocytes retrieval efficiency, but showed minimal influence on retrieved oocytes number and reproductive outcomes.

show abstract

Fresh versus elective frozen embryo transfer in IVF/ICSI cycles: a systematic review and meta-analysis of reproductive outcomes

Cited by 335 publications

References 79 publications

Human uterine transplantation: a review of outcomes from the first 45 cases

Human uterine transplantation: a review of outcomes from the first 45 cases

The cumulative live birth rate after a freeze-only strategy versus a conventional fresh embryo transfer strategy: a call for more level 1 evidence

Defining the Learning Curve is Necessary to Improve Oocyte Retrieval Skills: Lessons from A Single High-Volume Reproductive CenterDefining the Learning Curve is Necessary to Improve Oocyte Retrieval Skills: Lessons from A Single High-Volume Reproductive Center

Contact Info

Product

Resources

About