Fresh pomegranate juice ameliorates insulin resistance, enhances β-cell function, and decreases fasting serum glucose in type 2 diabetic patients

Banihani, Saleem Ali; Makahleh, Seham M.; El-Akawi, Zeyad; Al-Fashtaki, R.A.; Khabour, Omar F.; Gharibeh, M.Y.; Saadah, N.A.; Alhashimi, Farah H.; Al-Khasieb, N.J.

doi:10.1016/j.nutres.2014.08.003

Cited by 78 publications

(64 citation statements)

References 24 publications

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“…Some researchers speculated that pomegranate might prevent diabetic sequelae via peroxisome proliferator-activated receptor-gamma binding and nitric oxide production [46]. A clinical study that involved 85 participants with type 2 diabetes demonstrated that 3 hours after fresh pomegranate juice administration, the juice decreased fasting serum glucose (FSG) levels, increased β-cell function, and decreased insulin resistance [51].…”

Section: Bioactivity Of the Treated Juicementioning

confidence: 99%

Functional Properties of Punica granatum L. Juice Clarified by Hollow Fiber Membranes

et al. 2016

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Abstract:There is currently much interest in pomegranate juice because of the high content of phenolic compounds. Moreover, the interest in the separation of bioactive compounds from natural sources has remarkably grown. In this work, for the first time, the Punica granatum L. (pomegranate) juice-clarified by using polyvinylidene fluoride (PVDF) and polysulfone (PSU) hollow fiber (HF) membranes prepared in the laboratory-was screened for its antioxidant properties by using different in vitro assays, namely 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS), Ferric Reducing Antioxidant Power (FRAP), and β-carotene bleaching tests, and for its potential inhibitory activity of the carbohydrate-hydrolysing enzymes, α-amylase and α-glucosidase. The effects of clarification on quality characteristics of the juice were also investigated in terms of total phenols, flavonoids, anthocyanins, and ascorbic acid. Experimental results indicated that PVDF membranes presented a lower retention towards healthy phytochemicals in comparison to PSU membranes. Accordingly, the juice clarified with PVDF membranes showed the best antioxidant activity. Moreover, the treatment with PVDF membranes produced a clarified juice with 2.9-times fold higher α-amylase inhibitory activity in comparison to PSU (IC 50 value of 75.86 vs. 221.31 µg/mL, respectively). The same trend was observed using an α-glucosidase inhibition test. These results highlight the great potential of the clarified juice as a source of functional constituents.

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Section: Bioactivity Of the Treated Juicementioning

confidence: 99%

Functional Properties of Punica granatum L. Juice Clarified by Hollow Fiber Membranes

et al. 2016

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“…In our previous study on patients with type 2 diabetes, we have found a significant negative correlation between the antihyperglycemic effect of PGJ and the age of patients (Banihani et al, 2014). Actually, even though there was a decrease in the antihyperglycemic response versus age of individuals with IFG, but this decrease was not statistically significant.…”

Section: F I G U R Ementioning

confidence: 83%

“…Besides, insulin resistance was assessed 3 hr following the juice ingestion, a state where serum glucose level has been found to be significantly decreased even in patients with type 2 diabetes (Banihani et al, 2014). In general, the calculation of HOMA-IR level 3 hr after consumption of the juice might not be appropriate in nonfasting state; however, participants were not allowed to consume any food during the experiment and the juice was assumed as a treatment given during the fasting period.…”

Section: F I G U R Ementioning

confidence: 99%

“…Such compounds have antioxidant (Banihani, Shuaibu, Al-Husein, & Makahleh, 2019;Di Stefano et al, 2018), anti-carcinogenic (Sharma et al, 2017), anti-atherogenic (Rosenblat, Volkova, Borochov-Neori, Judeinstein, & Aviram, 2015), anti-inflammatory (Cho & Song, 2018), antihypertensive (Stowe, 2011), and antihyperglycemic effects (Banihani et al, 2014). Such compounds have antioxidant (Banihani, Shuaibu, Al-Husein, & Makahleh, 2019;Di Stefano et al, 2018), anti-carcinogenic (Sharma et al, 2017), anti-atherogenic (Rosenblat, Volkova, Borochov-Neori, Judeinstein, & Aviram, 2015), anti-inflammatory (Cho & Song, 2018), antihypertensive (Stowe, 2011), and antihyperglycemic effects (Banihani et al, 2014).…”

mentioning

confidence: 99%

“…A recent study has revealed positive effects of fresh PGJ administration in enhancing betta cell function and ameliorating insulin resistance in patients with type 2 diabetes (Banihani et al, 2014). The aim of the current investigation was to study the effects of fresh PGJ on impaired fasting glucose (IFG) conditions (also known as prediabetes), given that this phase in diabetes progression is the target for many researchers in the field to prevent and manage the onset of the disease.…”

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confidence: 99%

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Effect of fresh pomegranate juice on the level of melatonin, insulin, and fasting serum glucose in healthy individuals and people with impaired fasting glucose

Banihani

Fashtaky

Makahleh

et al. 2019

Food Science & Nutrition

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Pomegranate juice (PGJ) is rich in unique bioactive compounds that can be used in the management of various diseases/disorders such as cancer, heart disease, Alzheimer disease, hypertension, and diabetes. Here, we aimed to investigate the effects of fresh PGJ on levels of melatonin, insulin, and fasting blood glucose in people with impaired fasting glucose (IFG). The study was a randomized clinical trial in which 28 participants (10 males, 18 females) with IFG were recruited from Irbid Central Laboratory and the Diabetes Technology. Blood specimens from each participant were collected before (−5 min), and 1 and 3 hr after PGJ administration at 1.5 ml/kg of the body weight, and melatonin, insulin, and glucose were measured. People with IFG, but not healthy individuals, had significant antihyperglycemic response (p < .0001) to PGJ 3 hr after ingesting the juice. This response was not correlated with the age of participants (p = .4287).In addition, homeostatic model assessment of insulin resistance was significantly decreased (p < .0001) among people with IFG 3 hr after ingesting the juice. Moreover, 1 hr after PGJ administration, decreases in melatonin and increases in insulin were significantly observed among healthy (p = .0284, p = .0017) and IFG (p = .0056, p = .0007) individuals, respectively. In conclusion, fresh PGJ lowers melatonin, increases the level of insulin, and ameliorates insulin resistance in people with IFG.

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Pomegranates (Punica granatumL.)

Erkan

Kader

2017

Fruit and Vegetable Phytochemicals

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Fresh pomegranate juice ameliorates insulin resistance, enhances β-cell function, and decreases fasting serum glucose in type 2 diabetic patients

Cited by 78 publications

References 24 publications

Functional Properties of Punica granatum L. Juice Clarified by Hollow Fiber Membranes

Functional Properties of Punica granatum L. Juice Clarified by Hollow Fiber Membranes

Effect of fresh pomegranate juice on the level of melatonin, insulin, and fasting serum glucose in healthy individuals and people with impaired fasting glucose

Pomegranates (Punica granatumL.)

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