Fresh immature articular cartilage allografts

Abstract

The integration of immature cartilage allografts to knee joints of both normal rabbits and those submitted to arthritis through papain was studied for a period of up to 9 months. Two types of grafts were compared: chondral--constituted only by cartilage, and osteochondral--cartilage plus a thin layer of subchondral bone. The integration of the grafts was analyzed through inspection of the articular surface and histologic sections. The viability of the grafts was checked through the incorporation of 35SO4 on the chondral matrix. The following conclusions were drawn: (1) A large member of the grafted cartilages were well accepted without histological evidence of immunological rejection, and metabolically active 9 months after transplantation. (2) The chondral graft was found to be superior to the osteochondral one regarding the integration, but both showed tendency to degeneration with time. (3) The presence of arthritis previously induced by papain affected the integration of the grafts causing a higher precentage of degeneration on the grafts causing a higher precentage of degeneration on the grafted cartilage.

Gross and Histomorphological Studies of Femoral Head Resurfacing in Dog

“…coordination there was a single of chondrocyte and in some part cluster of cells was observed in group I animals (mals group I (control) was quite less than which was observed in grafted groups. There was a single row of chondrocytes and in some part cluster of cells was observed in group I animals [7] Fibrocartilage of cartilage defected area with increasing full thickness of cartilage have been reported in horses [8][9][10] . There was a similar report [7] at knee joint of rabbit.There was complete and uniform hyaline cartilage in group II animals which was indicative for foetal skull bone reparative cartilagenous cells to remodel itself into hyaline cartilage with active matrix layer [11,12] Klilson [13] reported that following increase in This study indicated that there was full thickness cartilage like tissues which was originated from foetal skull bone having mesenchymal tissues which further modify itself into cartilage in suitable environment.…”