Fresh Frozen Plasma as a Successful Antidotal Supplement in Acute Organophosphate Poisoning

Vučinić, Slavica; Zlatković, Milica; Antonijević, Biljana; Ćurčić, Marijana; Bošković, Bogdan

doi:10.2478/10004-1254-64-2013-2378

Cited by 15 publications

(12 citation statements)

References 13 publications

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“…Previous studies have reported that whole blood transfusion [13] or fresh frozen plasma transfusion [18] could restore enzymatic function by its scavenging effect. Packed RBC transfusion has advantages over those transfusions, since the small total volume administered to patients could avoid risks of overloading, fever, or allergy by components in the serum.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of fresh packed red blood transfusion in organophosphate poisoning

Bao

Tong

et al. 2017

Medicine

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The mortality rate caused by organophosphate (OP) poisoning is still high, even the standard treatment such as atropine and oxime improves a lot. To search for alternative therapies, this study was aimed to investigate the effects of packed red blood cell (RBC) transfusion in acute OP poisoning, and compare the therapeutic effects of RBCs at different storage times.Patients diagnosed with OP poisoning were included in this prospective study. Fresh RBCs (packed RBCs stored less than 10 days) and longer-storage RBCs (stored more than 10 days but less than 35 days) were randomly transfused or not into OP poisoning patients. Cholinesterase (ChE) levels in blood, atropine usage and durations, pralidoxime durations were measured.We found that both fresh and longer-storage RBCs (200–400 mL) significantly increased blood ChE levels 6 hours after transfusion, shortened the duration for ChE recovery and length of hospital stay, and reduced the usage of atropine and pralidoxime. In addition, fresh RBCs demonstrated stronger therapeutic effects than longer-storage RBCs.Packed RBCs might be an alternative approach in patients with OP poisoning, especially during early stages.

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Section: Discussionmentioning

confidence: 99%

Efficacy of fresh packed red blood transfusion in organophosphate poisoning

Bao

Tong

et al. 2017

Medicine

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“…New developments of in medical countermeasures also focus on detoxification of organophosphorus molecules by administration of stoichiometric or catalytic scavengers; protection and reactivation of central acetylcholinesterases; improvement of neuroprotection after delayed therapy; gene therapy for in situ generation of bioscavengers; and cell therapy based on neural progenitor . Another line of study in the domain of OP poisoning, which has also been carried out for decades, suggests the use of fresh frozen plasma in acute human OP poisoning when oximes are not available .…”

Section: Discussionmentioning

confidence: 99%

In Vivo Evaluation of Cholinesterase Activity, Oxidative Stress Markers, Cyto‐ and Genotoxicity of K048 Oxime – a Promising Antidote against Organophosphate Poisoning

Žunec

Kopjar

Želježić

et al. 2013

Basic Clin Pharma Tox

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K048 is a member of K-oximes, a new oxime class that has recently been confirmed effective against poisoning by the nerve agent tabun and several pesticides. The toxicity profile of the K048 oxime has not been fully characterized and its optimal therapeutic dose has not yet been established. Earlier studies report excellent results with K048 in reactivating tabun-phosphorylated AChE and in the therapy of tabun-poisoned mice. It possesses a low acute toxicity and exerts an acceptable toxicity profile on isolated human peripheral blood lymphocytes in vitro. Intraperitoneal administration of K048 in rats resulted in an LD 50 of 238.3 mg/kg. In this in vivo study, we investigated cholinesterase (ChE) activity and oxidative stress marker levels (lipid peroxidation and superoxide dismutase activity) in the plasma of exposed rats after administering the compound at 25% of its LD 50 . Lymphocyte viability was evaluated using an acridine orange/ethidium bromide in situ fluorescent assay. The levels of primary DNA damage in rat white blood cells were measured using the alkaline comet assay. The compound applied at 25% of its LD 50 did not significantly affect ChE activity and lipid peroxidation and did not cause significant changes in the SOD activity in plasma. The cytotoxicity profile of K048 in the tested dose was also acceptable, and it did not possess significant DNA-damaging potential. The obtained results are promising for further evaluations of the K048 oxime, which should include tests on a broader concentration range and longer incubation times.

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“…Previous studies have reported whole blood transfusion [9] or fresh frozen plasma transfusion [14] could restore the enzymatic function by its biscavenging effect. However, packed RBCs transfusion has advantages over whole blood transfusion, since the total volume administrated into patients is less that could avoid risks of overloading and fever or allergy by substances in serum.…”

Section: Discussionmentioning

confidence: 99%

Fresh Red Blood Transfusion as a Successful Erythrocyte Cholinesterase Supplement in Organophosphate Poisoning

Wang¹,

Huang²,

Chen³

et al. 2016

J Clinic Toxicol

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Despite improvements to standard treatments (atropine, oxime) and intensive care management, the mortality associated with organophosphate (OP) poisoning has not substantially decreased. In this study, we evaluated the role of packed red blood cells (RBCs) transfusion in acute OP poisoning. Patients diagnosed with OP poisoning were included in this prospective study, and then were transfused with packed RBCs stored less than 10 days or 10 to 35 days. Cholinesterase (ChE) level in blood, atropine usage and durations were recorded. We found both shorter-and longer-storage RBCs (200~400 ml) significantly increased AChE level in blood, improved ChE recovery, and reduced the usage and shortened the duration of atropine and followed clinical recovery. Shorter-storage RBCs had better effect than longer-storage (longer storage) ones. Due to erythrocyte cholinesterase supplement, packed RBCs might be used as an alternative approach in patients with OP poisoning, especially at the early stages.

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Fresh Frozen Plasma as a Successful Antidotal Supplement in Acute Organophosphate Poisoning

Cited by 15 publications

References 13 publications

Efficacy of fresh packed red blood transfusion in organophosphate poisoning

Efficacy of fresh packed red blood transfusion in organophosphate poisoning

In Vivo Evaluation of Cholinesterase Activity, Oxidative Stress Markers, Cyto‐ and Genotoxicity of K048 Oxime – a Promising Antidote against Organophosphate Poisoning

Fresh Red Blood Transfusion as a Successful Erythrocyte Cholinesterase Supplement in Organophosphate Poisoning

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