Fresh Frozen Plasma and Related Products

Crookes, Robert; Hillyer, Christopher D.

doi:10.1016/b978-0-443-06981-9.50024-7

Cited by 2 publications

(5 citation statements)

References 144 publications

(112 reference statements)

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“…Too rapid of an infusion can result in hypotension and is to be avoided. [57] In our study, we have not encountered any kind of severe form of citrate AEs.…”

Section: Discussionmentioning

confidence: 78%

“…Within the apheresis instrument, plasma citrate concentrations reach 15 to 24 mmol/L, lowering the calcium ion concentration below 0.2 to 0.3 mmol/L, the level necessary for clotting to occur. [457] This level of anticoagulation requires the infusion of approximately 500 ml of ACD-A solution and it would be expected that the infusion of this volume of solution into a donor would result in a calcium ion concentration of 0.2 mmol/l; a level incompatible with life. This does not occur, however, for a number of reasons.…”

Section: Discussionmentioning

confidence: 99%

“…The treatment includes slowing the re-infusion rate to allow for dilution and metabolism of the citrate, increasing donor blood to citrate ratio to decrease the amount of citrate infused, giving oral calcium supplement, and if required giving intravenous calcium. [3–57] The administration of oral calcium carbonate and its effects on citrate toxicity have recently been examined by Bolan et al . [8] These authors found that the administration of 2 g of calcium carbonate was associated with a statistically significant reduction in the severity of paresthesia.…”

Section: Discussionmentioning

confidence: 99%

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Adverse events associated with apheresis procedures: Incidence and relative frequency

Philip

Sarkar

Pathak

2013

Asian J Transfus Sci

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Introduction:Apheresis procedures [Plateletpheresis, Plasmapheresis/ Therapeutic Plasma Exchange (TPE), & Peripheral Blood Stem Cell Collection (PBSC)] are usually well tolerated. Occasionally, Adverse Events (AEs) of variable severity may occur during or after the procedure. AEs that occur in Donors/Patients are divided into local reactions and systemic reactions.Materials and Methods:A total of 3,367 apheresis procedures were performed, out of which 3,120 were plateletpheresis procedures, and out of which 1,401 were on Baxter CS 3000 & 1,719 were on Haemonetics MCS+ cell separators. Rest of 247 TPE & PBSC procedures were done on Haemonetics MCS+ cell separators.Results:90 AEs were reported in relation to the 3,367 procedures. Out of 90 AEs, 85 AEs (94%) were associated with plateletpheresis (n = 3,120) and 05 AEs (06%) with TPE & PBSC (n = 247). The rate of vascular injury (VI), Citrate reaction (CR), and Presyncopal/Syncopal (PS/S) in plateletpheresis was 1.6% (52/3,120), 0.96% (30/3,120), and 0.096% (03/3,120), respectively. The rate of CR in TPE and PBSC was 1.23% (02/162) and 2.3% (02/85), respectively. The rate of PS/S in PBSC was 1.17% (01/85). AEs for Plateletpheresis, TPE & PBSC were 2.7% (85/3,120), 1.23% (02/162), and 3.5% (03/85), respectively. VI, CR, and PS/S were mostly of mild intensity. Both cell separators were equally safe, when AEs associated with plateletpheresis were compared with each other; 2.8% on CS 3000 & 2.6% on MCS+.Conclusion:Apheresis procedures performed on cell separators are safe, with a low incidence of significant AEs. No significant difference was noted in AEs among the two cell separators studied.

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“…Too rapid of an infusion can result in hypotension and is to be avoided. [57] In our study, we have not encountered any kind of severe form of citrate AEs.…”

Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Adverse events associated with apheresis procedures: Incidence and relative frequency

Philip

Sarkar

Pathak

2013

Asian J Transfus Sci

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“…Local phlebitis and thrombophlebitis are very rare. 7 Systemic reactions were mainly associated with vasovagal reactions (VVR) that can be triggered by the pain of the venipuncture, or by anxiety. These were characterized by the pallor, sweating, dizziness, nausea, hypotension, bradycardia, and syncope.…”

Section: Methodsmentioning

confidence: 99%

“…Citrate toxicity occured because of the use of acid-citrate-dextrose (ACD) in apheresis. 7 NDR AEs were categorized as equipment/kit/technique related. Equipment related problems can be multiple like air purge failures, variation in the anticoagulant (AC) ratio, changes in calibration of equipment etc.…”

Section: Methodsmentioning

confidence: 99%

Profile of adverse events in plateletpheresis and plasmapheresis donors in a tertiary care hospital of North India

Bhardwaj,

Bassi,

Bhardwaj

2024

Int J Res Med Sci

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Background: Apheresis procedures are usually well tolerated. Adverse events (AEs) associated with the use of cell separators can be due to delivery of the anticoagulant, vasovagal, allergy, venous access or machines malfunction. Aim was to study the profile of adverse events of plateletpheresis and plasmapheresis donors. Methods: Plateletpheresis and plasmapheresis procedures enrolled for donors during 2017-2018 were done after taking informed and written consent by using Trima Accel and MCS+cell separator. Donor related AEs were categorised according to severity, site and etiology. Non-donor related (NDR) AEs were kit, technique, or equipment related. Results: 2859 procedures were done, 2836 (99.19%) plateletpheresis and 23 (0.8%) plasmapheresis. All 145 (5.07%) AEs were seen in plateletpheresis. Majority of AEs, 130 (4.54%) were DR. 15 (0.52%) were NDR. Commonest DR AEs was citrate related (CR) 76 (2.6%), followed by vasovagal reaction (VVR) in 31 (1.08%) and vascular injury in 23 (0.8%). Majority of the AEs were mild in 124 (4.33%), only 6 (0.20%) were moderate. 107 (3.74%) AEs were (VI) systemic, while 23 (0.80%) were local. In local AEs, hematomas were more common. First time donors had more AEs, 62/1234 (5.02%) as compared to the repeat donors 68/1625 (4.18%). CR AEs were more in repeat donors, 46 (2.8%) as compared to first time donors, 30 (2.43%). VVRs and VIs were more in first time as compared to the repeat donors. NDR AEs were 15 (0.52%). Conclusions: Donor vigilance, trained technical personnel and specialists’ supervision are vital for donor safety hence affecting apheresis donor pool.

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Fresh Frozen Plasma and Related Products

Cited by 2 publications

References 144 publications

Adverse events associated with apheresis procedures: Incidence and relative frequency

Adverse events associated with apheresis procedures: Incidence and relative frequency

Profile of adverse events in plateletpheresis and plasmapheresis donors in a tertiary care hospital of North India

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