2003
DOI: 10.1128/jcm.41.1.159-163.2003
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Frequent Recovery of a Single Clonal Type of Multidrug-Resistant Staphylococcus aureus from Patients in Two Hospitals in Taiwan and China

Abstract: One hundred thirty-two methicillin-resistant Staphylococcus aureus (MRSA) isolates recovered from patients with S. aureus infections between January 1998 and February 1999 in two hospitals, one located in Taipei, Taiwan, and another in Nanjing, People's Republic of China, were examined for antibiotic susceptibility and for clonal type by a combination of three methods: hybridization of ClaI restriction digests with mecA-and Tn554-specific DNA probes and pulsed-field gel electrophoresis of chromosomal SmaI dige… Show more

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Cited by 116 publications
(94 citation statements)
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References 26 publications
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“…Most of the MRSA isolates belonging to ST239 from India, Indonesia, Singapore, Sri Lanka, Taiwan, and Greece were resistant to SXT (1,3,16), while those from China, Vietnam, and the Czech Republic were susceptible (3,16,17). These data, combined with our current results, suggest that the susceptibility of MRSA isolates belonging to ST239 to SXT is different between the bacterial isolation sites.…”
Section: Resultssupporting
confidence: 75%
See 1 more Smart Citation
“…Most of the MRSA isolates belonging to ST239 from India, Indonesia, Singapore, Sri Lanka, Taiwan, and Greece were resistant to SXT (1,3,16), while those from China, Vietnam, and the Czech Republic were susceptible (3,16,17). These data, combined with our current results, suggest that the susceptibility of MRSA isolates belonging to ST239 to SXT is different between the bacterial isolation sites.…”
Section: Resultssupporting
confidence: 75%
“…Phylogenetic studies by molecular typing techniques have shown that only a few epidemic MRSA clones are responsible for the large proportion of MRSA infections worldwide (3,6,8,10,23,25,30). Five major internationally spread epidemic MRSA clones, the Iberian (7,12,27), Brazilian (31), Hungarian (6,22), New York/Japan (2,24), and pediatric (26) 2004.…”
mentioning
confidence: 99%
“…There is a good correlation between clonal groupings determined by MLST and the respective spa types (3,4,23,24). Examples have been reported of isolates with the same spa type belonging to related MLST sequence types that arose by single-locus variation (5). On the other hand, there seems to be a considerable degree of spa gene repeat number variation within a given sequence type, suggesting that spa typing in some instances provides greater resolution than MLST (3,23).…”
mentioning
confidence: 88%
“…42, 2004 DISCRIMINATION AMONG S. AUREUS ISOLATES BY spa TYPING 797 the thousands of S. aureus isolates that we have attempted to spa type was typeable. Use of the alternative primer used in this study for MSA 2389 is suggested in the very rare instances of no spa amplification (8,26), which are likely due to sequence mutations in the primer region. In order to understand why spa typing is so highly discriminating, it is important to analyze two major contributory components of discriminatory power in a sequence-based VNTR typing system: the background rate of nucleotide mutation within the repeats and the extent of repeat number variation (i.e., variability in repeat region size).…”
Section: Discussionmentioning
confidence: 99%