Frequent polymorphisms of FSH receptor do not influence antral follicle responsiveness to follicle-stimulating hormone administration as assessed by the Follicular Output RaTe (FORT)

Abstract

Antral follicle responsiveness to FSH, as far as measured by the FORT, is not influenced by the presence of SNPs of FSHR 307Ala and 680Ser.

MECHANISMS IN ENDOCRINOLOGY: Genetics of FSH action: a 2014-and-beyond view

“…The data reported in Supplementary Table 1 show that some studies confirmed our original results (29,36,37,38,39,40) but others did not, especially those conducted in women of advanced age (41,42,43,44). Serum FSH levels were not significantly different between FSHR genotypes in older women (41,42,43,44) and in conditions of very high FSH concentrations, such as in postmenopausal women (45) and in women with premature ovarian failure (46).…”

“…Serum FSH levels were not significantly different between FSHR genotypes in older women (41,42,43,44) and in conditions of very high FSH concentrations, such as in postmenopausal women (45) and in women with premature ovarian failure (46). Patient inclusion criteria are important as well, because studies excluding (young) women with basal FSH levels O10 IU/l, potentially excluding p.N680S S carriers, did not reveal any genotype-related difference (37,47,48).…”

Effect of follicle-stimulating hormone receptor Asn680Ser polymorphism on the outcomes of controlled ovarian hyperstimulation: an updated meta-analysis of 16 cohort studies

“…A total of 1019 citations were initially retrieved with our search strategy, in which 1003 citations were carefully excluded. Only 16 studies involving 4287 patients were included in our meta-analysis [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27]. The process of identification of the eligible studies and the reasons for exclusion were presented in Fig.…”

“…In addition to these SNPs, splice variants in FSHR that have been identified in women undergoing ovarian stimulation may also contribute to the variability in ovarian response. However, results from multiple studies are conflicting, and previous meta-analyses have failed to confirm the association between FSHR Asn680Ser polymorphism and the outcomes related to COH [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29]. A pooled analysis of only four studies, as well as a recent meta-analysis, showed that the 680 SS genotype of FSHR played a role in the ovarian response during stimulation with exogenous gonadotropin [11,30].…”

The carriers of the A/G-G/G allelic combination of the c.2039 A>G and c.-29 G>A FSH receptor polymorphisms retrieve the highest number of oocytes in IVF/ICSI cycles

“…Furthermore, in a small study conducted with 37 patients, the A/A (Asn/Asn) variant was correlated to the severity of ovarian hyperstimulation syndrome (OHSS) [21]. In other studies, the association of the G/G variant with a poor ovarian response was not demonstrated, either for the number of oocytes retrieved [22] or for the FORT [23]. Even those patients who were homozygous for the G/G variant revealed a higher number of mature oocytes than the patients homozygous for the A/A variant [10].…”