Frequent loss of p53 codon 72 Pro variant in hepatitis C virus-positive carriers with hepatocellular carcinoma

Anzola, M.; Cuevas, N; López-Martı́nez, Mónica; Saiz, Alberto; Burgos, Juan José Peña; Pancorbo, Marian M. de

doi:10.1016/s0304-3835(03)00046-6

Cited by 44 publications

(33 citation statements)

References 27 publications

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“…In addition, 73.6% (53/72) of those who showed LOH of the p53 gene had lost the Pro allele. These results are consistent with those reported by other authors for some tumour types, in which it has been pointed out that LOH of p53 occurs more commonly for the Pro allele and that there is a preferential mutation of the Arg72 allele Marin et al, 2000;Tada et al, 2001;Furihata et al, 2002;Anzola et al, 2003). Based on the reports assigning a higher apoptotic potential to the Arg allele (Wu et al, 2002) and the current data, we could hypothesise that the cells carrying an Arg allele require further p53 mutations to increase their tumorigenic potential, while Pro/Pro cells could undergo this procedure with fewer damage.…”

Section: Discussionsupporting

confidence: 93%

p53 polymorphisms associated with mutations in and loss of heterozygosity of the p53 gene in male oral squamous cell carcinomas in Taiwan

Huang

et al. 2004

Br J Cancer

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The present study was designed to examine whether different p53 haplotypes of exon 4 -intron 3 -intron 6 affect the frequency of mutations and loss of heterozygosity (LOH) of the p53 gene in male oral squamous cell carcinomas (OSCCs) in Taiwan. We found that individuals without two Pro-W-G alleles had significantly higher frequency of p53 mutations than those with two Pro-W-G alleles (odds ratio (OR) ¼ 1.98; 95% confidence interval (CI), 1.10 -3.56). Out of the 172 p53 gene exon 4 informative male OSCCs, 72 (41.9%) showed LOH. Among these 72 OSCCs with LOH, the frequency of Pro allele loss was 73.6% (53/72). It is notable that alcohol drinking increased the frequency of Arg allele loss (OR ¼ 10.56; 95% CI, 1.23 -234.94) in OSCCs from patients who both smoked cigarettes and chewed areca quid (AQ). The frequency of LOH of p53 was not different between p53-mutated OSCCs and p53-normal OSCCs. Thus, the present study revealed that (a) the Arg allele is associated with p53 mutations, (b) the Pro allele is preferentially lost in OSCCs associated with cigarette smoking and AQ chewing, while the frequency of Arg allele loss is increased with alcohol drinking, and (c) haploinsufficiency of p53 is in itself likely to contribute to tumour progression in Taiwanese OSCCs.

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Section: Discussionsupporting

confidence: 93%

p53 polymorphisms associated with mutations in and loss of heterozygosity of the p53 gene in male oral squamous cell carcinomas in Taiwan

Huang

et al. 2004

Br J Cancer

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“…The 72R allele of mutant p53 has been found to have greater ability to bind p73, neutralizing p73-induced apoptosis, when compared to the mutant 72P allele . Moreover, the 72R allele is preferentially mutated and retained in various human tumors arising in RP germline heterozygotes Kawaguchi et al, 2000;Tada et al, 2001;Langerod et al, 2002;Papadakis et al, 2002;Anzola et al, 2003;Schneider-Stock et al, 2004a;Hsieh et al, 2005). Recently a positive association of the 72R allele with p53 overexpression has been reported in esophageal cancer tissue (Lee et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Association of p53 codon 72 polymorphism with liver metastases of colorectal cancers positive for p53 overexpression

Zhu¹,

Liu

Wang³

et al. 2008

J. Zhejiang Univ. Sci. B

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Abstract:Objective: To evaluate the association between p53 codon 72 polymorphism (R72P) and the risk of colorectal liver metastases. Methods: The p53 R72P genotype was identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method in 78 consecutive colorectal cancer patients with liver metastases and 214 age-and sex-matched cases with nonmetastatic colorectal cancer. Results: The R allele of the p53 R72P polymorphism was more frequently found in metastatic cases than in nonmetastatic cases (P=0.075). Carriers of the 72R allele had a 2.25-fold (95% CI (confidence interval)=1.05~4.83) increased risk of liver metastases. On the stratification analysis, 72R-carrying genotype conferred a 3.46-fold (95% CI=1.02~11.72) and a 1.05-fold (95% CI=0.36~3.08) increased risk of liver metastases for p53 overexpression-positive and negative colorectal cancers, respectively. Conclusion: These results demonstrate for the first time that the 72R allele of the p53 polymorphism has an increased risk for liver metastases in colorectal cancers positive for p53 overexpression.

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“…14 However, the issue is still controversial in some other types of cancers and in some ethnic groups. [15][16][17][18][19][20] This study was undertaken to investigate the association of p53 codon 72 polymorphism with BCC in southern Iranian patients.…”

Section: 2% P=003) Our Results Suggest Thatmentioning

confidence: 99%

601 p53 codon 72 polymorphism in basal cell carcinoma of skin

Pezeshki¹,

Aslani²,

Ghaderi³

et al. 2003

European Journal of Cancer Supplements

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Frequent loss of p53 codon 72 Pro variant in hepatitis C virus-positive carriers with hepatocellular carcinoma

Cited by 44 publications

References 27 publications

p53 polymorphisms associated with mutations in and loss of heterozygosity of the p53 gene in male oral squamous cell carcinomas in Taiwan

p53 polymorphisms associated with mutations in and loss of heterozygosity of the p53 gene in male oral squamous cell carcinomas in Taiwan

Association of p53 codon 72 polymorphism with liver metastases of colorectal cancers positive for p53 overexpression

601 p53 codon 72 polymorphism in basal cell carcinoma of skin

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