Frequent involvement of chromosomes 1, 3, 7 and 8 in splenic marginal zone B‐cell lymphoma

Solé, Françesc; Woessner, S; Florensa, Lourdes; Espinet, Blanca; Mollejo, Manuela; Martín, Pedro Beneyto; Piris, Miguel Á.

doi:10.1046/j.1365-2141.1997.2163033.x

Cited by 55 publications

(29 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…4,6 The selection of cases used here, taking splenic histology into account together with the other features of the tumors, made it possible to restrict the cases included to a relatively homogeneous histological type, thus avoiding any bias arising from the selection of the sample.…”

Section: Discussionmentioning

confidence: 99%

“…Cytogenetic analysis of SMZL cases has showed diverse abnormalities at chromosomes 1, 3, 7, and 8, 4 -5 chromosome 7 being the most frequently altered (3/19 cases). 4 Some SMZL cases showed del 7q as the only cytogenetic abnormality, this chromosome loss being found in 7q22 as well as in 7q32. 4 7q abnormalities have been previously published in studies of other chronic lymphoproliferative disorders by cytogenetic techniques.…”

mentioning

confidence: 99%

“…4 Some SMZL cases showed del 7q as the only cytogenetic abnormality, this chromosome loss being found in 7q22 as well as in 7q32. 4 7q abnormalities have been previously published in studies of other chronic lymphoproliferative disorders by cytogenetic techniques. 6 -10 Most reports center on tumors that may at least partially overlap SMZL, such as immunocytoma and splenic lymphoma with circulating villous lymphocytes (SLVL).…”

mentioning

confidence: 99%

See 2 more Smart Citations

7q31-32 Allelic Loss Is a Frequent Finding in Splenic Marginal Zone Lymphoma

Mateo

Mollejo

Villuendas

et al. 1999

The American Journal of Pathology

Self Cite

151

View full text Add to dashboard Cite

Splenic marginal zone lymphoma (SMZL) has been recognized as an entity defined on the basis of its morphological , phenotypic , and clinical characteristic features. Nevertheless , no characteristic genetic alterations have been described to date for this entity, thus making an exact diagnosis of SMZL difficult in some cases. As initial studies showed that chromosome region 7q22-32 is deleted in some of these cases, we analyzed a larger group of SMZL and other lymphoproliferative disorders that may partially overlap with it. To better define the frequency of 7q deletion in SMZL and further identify the deleted region , polymerase chain reaction analysis of 13 microsatellite loci spanning 7q21-7q36 was performed on 20 SMZL and 26 non-SMZL tissue samples. The frequency of allelic loss in SMZL (8/20; 40%) was higher than that observed in other B-cell lymphoproliferative syndromes (2/26; 7.7%). This difference was statistically significant (P < 0.05). The most frequently deleted microsatellite was D7S487 (5/11; 45% of informative cases). Surrounding this microsatellite the smallest common deleted region of 5cM has been identified, defined between D7S685 and D7S514. By comparative multiplex polymerase chain reaction analysis , we detected a homozygous deletion in the D7S685 (7q31.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

7q31-32 Allelic Loss Is a Frequent Finding in Splenic Marginal Zone Lymphoma

Mateo

Mollejo

Villuendas

et al. 1999

The American Journal of Pathology

Self Cite

151

View full text Add to dashboard Cite

show abstract

“…6 -9 In previous studies we have reported that in some SMZL cases, the only cytogenetic abnormality displayed was del(7q) that could suggest that del(7q) is associated with SMZL. 6,10 Recently, loss of heterozygosity studies demonstrated that the frequency of allelic loss in SMZL (40%) is higher than that observed in other B-cell lymphoproliferative syndromes. The most frequently deleted microsatellite was D7S487.…”

mentioning

confidence: 99%

“…Cytogenetic analyses have shown involvement of chromosomes 1, 3, 7, and 8. 5,6 Fluorescence in situ hybridization studies on interphase nuclei have demonstrated the presence of trisomy 3 in a proportion of cases ranging from 18 to 47% of SMZL. 6 -9 In previous studies we have reported that in some SMZL cases, the only cytogenetic abnormality displayed was del(7q) that could suggest that del(7q) is associated with SMZL.…”

mentioning

confidence: 99%

Novel Genomic Imbalances in B-Cell Splenic Marginal Zone Lymphomas Revealed by Comparative Genomic Hybridization and Cytogenetics

Hernández

Garcı́a

Gutiérrez

et al. 2001

The American Journal of Pathology

Self Cite

View full text Add to dashboard Cite

Splenic marginal zone lymphoma (SMZL) has recently been recognized in the World Health Organization classification of hematological diseases as distinct type of non-Hodgkin's lymphoma. In contrast to the well-established chromosomal changes associated with other B-cell non-Hodgkin's lymphoma, few genetic alterations have been found associated with SMZL. The aim of our study was to analyze by comparative genomic hybridization (CGH) the chromosomal imbalances in 29 patients with SMZL and to correlate these findings with clinical and biological characteristics and patient outcome. In 21 cases, cytogenetic studies were simultaneously performed. Most of the patients (83%) displayed genomic imbalances. A total of 111 DNA copy number changes were detected with a median of four abnormalities per case (range, 1 to 12). Gains (n ‫؍‬ 92) were more frequent than losses (n ‫؍‬ 16), while three high-level amplifications (3q26-q29, 5p11-p15, and 17q22-q25) were observed. The most frequent gains involved 3q (31%), 5q (28%), 12q and 20q (24% each), 9q (21%), and 4q (17%). Losses were observed in 7q (14%) and 17p (10%). SMZL patients with genetic losses had a shorter survival than the remaining SMZL patients (P < 0.05). Splenic marginal zone lymphoma (SMZL) has been considered a subtype of B-cell non-Hodgkin's lymphoma (NHL) in the recent classification of hematological diseases.1 SMZL has been recognized as a separate entity on the basis of its morphological, phenotypic, and clinical characteristics.2 Several studies have been performed to assess the genetic abnormalities in marginal lymphomas. Recently, two translocations, t(1;14)(p22;q32) involving BCL10/IgH 3 and t(11;18)(q21;q21) -API2/MLT-4 have been described, associated with high-grade and lowgrade MALT lymphomas, respectively. However, genetic information of SMZL is scanty. Cytogenetic analyses have shown involvement of chromosomes 1, 3, 7, and 8. 5,6 Fluorescence in situ hybridization studies on interphase nuclei have demonstrated the presence of trisomy 3 in a proportion of cases ranging from 18 to 47% of SMZL. 6 -9 In previous studies we have reported that in some SMZL cases, the only cytogenetic abnormality displayed was del(7q) that could suggest that del(7q) is associated with SMZL. 6,10 Recently, loss of heterozygosity studies demonstrated that the frequency of allelic loss in SMZL (40%) is higher than that observed in other B-cell lymphoproliferative syndromes. The most frequently deleted microsatellite was D7S487.11 These results are in accordance with our fluorescence in situ hybridization studies that mapped the commonly deleted region in chronic B-cell lymphoproliferative disorders at 7q31.3.

show abstract