Frequent injecting impairs lymphocyte reactivity in HIV-positive and HIV-negative drug users

Mientjes, G. H. C.; Miedema, Frank; Ameijden, E. J. Van; Hoek, A. A. Van Den; Schellekens, P. T. A.; Roos, Malgorzata; Coutinho, Roel A.

doi:10.1097/00002030-199101000-00005

Cited by 51 publications

(27 citation statements)

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“…Laboratory studies have reported that heroin and cocaine alter results of immunological assays and tend to stimulate HIV activity in vitro 26 27 28 29. However, we found no important difference between users of injected drugs and those infected by homosexual or heterosexual sex, which is consistent with other comparisons between exposure categories 30 31.…”

Section: Discussionsupporting

confidence: 90%

Category of exposure to HIV and age in the progression to AIDS: longitudinal study of 1199 people with known dates of seroconversion

Pezzotti

Phillips

Dorrucci

et al. 1996

BMJ

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Section: Discussionsupporting

confidence: 90%

Category of exposure to HIV and age in the progression to AIDS: longitudinal study of 1199 people with known dates of seroconversion

Pezzotti

Phillips

Dorrucci

et al. 1996

BMJ

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“…In vitro studies have demonstrated that opiates and cocaine up-regulate HIV-1 replication (17,18). Drug use may also directly contribute to immunosuppression (19). Some epidemiological research has demonstrated a relationship between drug use and HIV progression such that drug use was related to faster HIV decline.…”

Section: Illicit Drug Use and Hiv Disease Progressionmentioning

confidence: 99%

Behavioral Mediation of the Relationship Between Psychosocial Factors and HIV Disease Progression

Gore‐Felton

Koopman

2008

Psychosomatic Medicine

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The psychological and physical demands of coping with medication side effects and comorbid illnesses can be overwhelming and may influence behaviors, such as medication adherence, substance use, sexual risk behavior, and exercise that, in turn, affect health outcomes. Cross-sectional and prospective studies among diverse populations of persons living with HIV suggest that these behavioral mechanisms may be associated with HIV disease progression. The motivation to change behavior is often highest in the immediate aftermath of a stressor. However, over time the motivation to continue a particular behavior change is often challenged by habits, environmental influences, and psychosocial factors. Furthermore, a number of studies suggest that behavioral mechanisms may mediate the relationship between psychosocial variables (e.g., stress, depression, coping, and social support) and disease progression in HIV. Thus, developing clinical interventions that address these psychosocial factors and enhance protective health behaviors and reduce behaviors that convey risk to health are likely to lessen overall morbidity and mortality among patients living with HIV/AIDS.

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“…Little has been published specifically on seroconversion illness In mus, although there are theoretical reasons for thinking that it may vary from other groups. HIV-negative mus have been shown to have evidence of altered immune function 35 and the life style associated with drug use renders them susceptible to a wide range of illnesses, particularly bacterial infections. A recent study from Amsterdam" followed 18 mus who seroconverted, and reported 6 (33%) patients to have serious manifestations associated with seroconversion, of whom 5 required admission to hospital for bacterial pneumonia and one developed oesophageal candidiasis.…”

Section: Seroconversion Illness In Idusmentioning

confidence: 99%

Clinical Management of HIV Disease in Intravenous Drug-Users

Sherrard

Bingham

Onen³

1993

Int J STD AIDS

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Intravenous drug-users comprise a major group of HIV-infected individuals in the developed world and, whilst progression of HIV disease in them appears little different from other risk groups, their medical presentations may be altered by continuing drug use. Drug-users are particularly susceptible to bacterial infections irrespective of their HIV status; they may present with symptoms directly caused by their drugs, which can be difficult to differentiate from non-drug-related causes and may closely resemble symptoms directly attributable to HIV. In addition, the life style associated with drug use can make compliance difficult, but in clinics combining HIV care and methadone prescribing these problems can be overcome.

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Frequent injecting impairs lymphocyte reactivity in HIV-positive and HIV-negative drug users

Cited by 51 publications

References 0 publications

Category of exposure to HIV and age in the progression to AIDS: longitudinal study of 1199 people with known dates of seroconversion

Category of exposure to HIV and age in the progression to AIDS: longitudinal study of 1199 people with known dates of seroconversion

Behavioral Mediation of the Relationship Between Psychosocial Factors and HIV Disease Progression

Clinical Management of HIV Disease in Intravenous Drug-Users

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