Frequent inactivation of <i>hSRBC</i> in ovarian cancers by promoter CpG island hypermethylation

Tong, Seo Yun; Ki, Kyung‐Do; Lee, Jong Min; Mj, Kang; Ha, Tae Kyu; Chung, Seong In; Gil, Sung; Lee, Seon Kyung

doi:10.3109/00016341003678443

Cited by 21 publications

(26 citation statements)

References 17 publications

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“…Several studies have found that down-regulation of SRBC was due to promoter hypermethylation in breast cancer cell lines [Xu et al, 2001;Tong et al, 2010]. We showed here that PTRF, SRBC, and SDPR were down regulated in breast cancer cells.…”

Section: Down-regulation Of Ptrf In Breast Cancer Tissue and Cell Linsupporting

confidence: 63%

Down‐regulation of the cavin family proteins in breast cancer

Bai

Duan

et al. 2011

J of Cellular Biochemistry

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Caveolae are abundant membrane domain on the cell surface of many mammalian cell types and are implicated in a wide range of physiological processes. The caveolae structural protein caveolin-1 is often mutated or deregulated in cancer, and cavin family protein serum deprivation response factor-related gene product that binds to C-kinase (SRBC) has been found to be epigenetically inactivated in lung, breast, and gastric cancer. Both caveolin-1 and SRBC have been proposed to function as tumor suppressors. Polymerase 1 and transcript release factor (PTRF) is the essential component for caveolae formation. The regulation of PTRF expression in cancer has not been characterized. We report here that the cavin family protein PTRF, SRBC and serum deprivation response protein were down regulated in breast cancer cell lines and breast tumor tissue. We further show that down-regulation of PTRF in breast cancer cells was associated with the promoter methylation. As caveolin-1 and cavin family proteins are required for caveolae formation and function, the reported tumor suppression function of caveolin-1 and SRBC may be due to the deregulation of caveolae and its down-stream signaling. Thus, the caveolae is a potential therapeutic target and the expression of cavin family proteins could be a useful prognostic indicator of breast cancer progression.

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Section: Down-regulation Of Ptrf In Breast Cancer Tissue and Cell Linsupporting

confidence: 63%

Down‐regulation of the cavin family proteins in breast cancer

Bai

Duan

et al. 2011

J of Cellular Biochemistry

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“…[136] Cavin3 is frequently inactivated in ovarian cancers. [137] Cavin3 is also down-regulated in breast cancer cell lines and breast tumor tissue. [131] Cavin3 may repress matrix metalloproteinase-9 transcriptional regulation and act as tumor suppressor in controlling the invasive potential of cells.…”

Section: Caveolae New Partners and Cancermentioning

confidence: 99%

Caveolae and cancer: A new mechanical perspective

Lamaze¹,

Torrino²

2015

Biomed J

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“…Silencing of tumor suppressor genes mediated by DNA methylation is a hallmark of human cancer [14]. Lower expression/loss of function due to epigenetic inactivation via aberrant methylation has been reported for RASSF1A [8,15], APC [16], RB1 [11,17], P16 [9] and PRKCDBP [18][19][20], as an important factor for development of various cancers.…”

Section: Introductionmentioning

confidence: 98%