Frequent hepatocyte growth factor overexpression and low frequency of c-Met gene amplification in human papillomavirus–negative tonsillar squamous cell carcinoma and their prognostic significances

Kwon, Mi Jung; Kim, Dong Hoon; Park, Hye-Rim; Shin, Hyung Sik; Kwon, Ji Hyun; Lee, Dong Jin; Kim, Jin Hwan; Cho, Seong Jin; Nam, Eun Sook

doi:10.1016/j.humpath.2014.03.003

Cited by 34 publications

(55 citation statements)

References 31 publications

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“…After title and abstract checking, 36 studies remained for the further evaluating in details, in which 15 articles were excluded for there were no enough data to calculate the survival rate [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27], one article was removed because of duplication [28]. So, a total of 20 publications were fulfilled the eligibility criteria [5][6][7][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45]. Among them, one study was excluded by the poor data quality [45], so 19 publications were included in the final analysis.…”

Section: Literature Searching and Study Characteristicsmentioning

confidence: 99%

“…The details of the procedures of literature screening were shown in Figure 1. Among the 19 studies, 5 studies reported head and neck cancer without site information [7,33,36,39,43], 4 studies focused on oral and oropharyngeal cancer [30,32,40,44], 3 for tongue cancer [6,29,34], 3 for nasopharyngeal cancer [5,35,42], 2 for salivary gland cancer [37,38], 1 for hypopharyngeal cancer [41] and another one for tonsillar cancer [31]. The total number of patients included in the meta-analysis was 2,417, the mean sample size was 127 (ranges from 33 to 396).…”

Section: Literature Searching and Study Characteristicsmentioning

confidence: 99%

See 1 more Smart Citation

WITHDRAWN: A meta-analysis of c-Met expression in head and neck cancer

Li¹,

Sun²,

Sun³

et al. 2017

Oncotarget

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Section: Literature Searching and Study Characteristicsmentioning

confidence: 99%

Section: Literature Searching and Study Characteristicsmentioning

confidence: 99%

WITHDRAWN: A meta-analysis of c-Met expression in head and neck cancer

Li¹,

Sun²,

Sun³

et al. 2017

Oncotarget

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“…4 and Table S4). Controversial findings exist regarding the prognostic significance of c-Met in HNSCC (11, 35, 36). These discrepancies are likely due to differences in the tumor sites investigated, analytical methods used (whether HPV status is stratified, e.g.…”

Section: Discussionmentioning

confidence: 99%

Human papillomavirus oncoprotein E6 upregulates c-Met through p53 downregulation

Qian

Wang

Magliocca

et al. 2016

European Journal of Cancer

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Purpose Human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) carries a distinct clinical behavior. c-Met oncogene is an important driver for tumor progression and its relationship with HPV in OPSCC was explored in the current study. Experimental Design Knockdown of HPV oncogene E6 or p53 alone and in combination was performed to examine their effects on c-Met expression by western blot and qRT-PCR. The effects of c-Met inhibition on cell proliferation, migration, and colony formation were examined in HPV-positive head and neck squamous cell carcinoma (HNSCC) cells. Retrospectively collected OPSCC patient specimens (N = 78) were stained for c-Met by immunohistochemistry and the staining levels were correlated with HPV status and patient outcomes. Results E6 knockdown decreased c-Met protein and mRNA expression in HPV-positive HNSCC cells, which was partially abolished by the elimination of p53. Reducing c-Met decreased cell proliferation, migration, and colony formation in HPV-positive HNSCC cells. In OPSCC patient samples, high c-Met expression was associated with HPV positive status (OR = 4.11, 95%CI: 1.16–14.55, P = 0.028) and tumor stage (OR = 0.27, 95%CI: 0.08–0.93, P = 0.039) by multivariable analysis. In T3/T4 stage patients, high c-Met expression was associated with HPV positivity and low p53 levels, supporting an axis of E6-p53-c-Met regulation. Furthermore, high c-Met expression was marginally associated with poor disease-free survival in HPV-positive patients. Conclusions Our results suggest that c-Met may serve as a novel target for treating HPV-associated OPSCC. The data also demonstrates that HPV E6 upregulates c-Met expression partially through p53 downregulation.

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“…[10][11][12][13] To ascertain whether aberrant c-Met expression accompanies human salivary ACC, we used immunohistochemical analysis to examine c-Met protein expression in 200 samples and concluded that 52% of tumors are strongly positive. Overexpression of Our study describes the largest screening of ACC samples for c-MET expression.…”

Section: Discussionmentioning

confidence: 99%