Frequent expression of CCR4 in adult T-cell leukemia and human T-cell leukemia virus type 1–transformed T cells

Yoshie, Osamu; Fujisawa, Ryuichi; Nakayama, Takashi; Harasawa, Hitomi; Tago, Hideaki; Izawa, Dai; Hieshima, Kunio; Tatsumi, Youichi; Matsushima, Kouji; Hasegawa, Hitoshi; Kanamaru, Akihisa; Kamihira, Shimeru; Yamada, Yasuaki

doi:10.1182/blood.v99.5.1505

Cited by 273 publications

(262 citation statements)

References 48 publications

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“…32,33 Although the proportion of CD4 þ CCR4 þ cells and CD4 þ CD70 þ cells in the PBMCs from healthy individuals were found to be approximately 5%, 27,33 the proportion of CD4 þ CADM1 þ cells was o1% ( Figure 2); therefore, measurement of CADM1 þ T cells is particularly efficient in the diagnosis of HTLV-1 infection in individuals who carry a small number of HTLV-1-infected cells. We have demonstrated previously that CADM1 has important functions in increasing cell adhesion and mediating progression to organ invasion.…”

Section: Discussionmentioning

confidence: 99%

Clinical significance of CADM1/TSLC1/IgSF4 expression in adult T-cell leukemia/lymphoma

et al. 2012

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Cell adhesion molecule 1 (CADM1/TSLC1) was recently identified as a novel cell surface marker for adult T-cell leukemia/ lymphoma (ATLL). In this study, we developed various antibodies as diagnostic tools to identify CADM1-positive ATLL leukemia cells. In flow cytometric analysis, the percentages of CD4 þ CADM1 þ double-positive cells correlated well with both the percentages of CD4 þ CD25 þ cells and with abnormal lymphocytes in the peripheral blood of patients with various types of ATLL. Moreover, the degree of CD4 þ CADM1 þ cells over 1% significantly correlated with the copy number of the human T-lymphotropic virus type 1 (HTLV-1) provirus in the peripheral blood of HTLV-1 carriers and ATLL patients. We also identified a soluble form of CADM1 in the peripheral blood of ATLL patients, and the expression levels of this form were correlated with the levels of soluble interleukin 2 receptor alpha. Moreover, lymphomas derived from ATLL were strongly and specifically stained with a CADM1 antibody. Thus, detection of CD4 þ CADM1 þ cells in the peripheral blood, measurement of serum levels of soluble CADM1 and immunohistochemical detection of CADM1 in lymphomas would be a useful set of markers for disease progression in ATLL and may aid in both the early diagnosis and measurement of treatment efficacy for ATLL.

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Section: Discussionmentioning

confidence: 99%

Clinical significance of CADM1/TSLC1/IgSF4 expression in adult T-cell leukemia/lymphoma

et al. 2012

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“…Adult T cell leukemia (ATL) cells are characterized by frequent expression of CCR4 and can migrate in vitro to CCL17 and CCL22, which are ligands for CCR4 [35]. The CCL17/CCL22-CCR4 axis may account for the frequent infiltration of ATL into skin and lymph nodes, where CCL17 and CCL22 are abundantly expressed.…”

Section: Direct Effects On Cancer Cellsmentioning

confidence: 99%

Chemokines in tumor development and progression

Mukaida

Baba

2012

Experimental Cell Research

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“…Various cutaneous lesions have been described in ATL lymphoma, including papules, nodules, erythroderma, plaques, tumors, and ulcerative lesions. The frequent expression of the chemokine (C-C motif) receptor 4 (CCR4) on the surface of tumor cells may in part explain skin involvement [45,46]. Other factors such as expression of cutaneous lymphocyte antigen (CLA) [47,48], expression of lymphocyte chemoattractant chemokine, stromal cell-derived factor/pre-B-cell growth-stimulating factor (SDF-1/PBSF) [45], as well as inflammatory responses may lead to chemotaxis of infected lymphocytes [49] and contribute to skin infiltration by ATL cells.…”

Section: Htlv-i-associated Cutaneous T-cell Lymphoma (Ctcl)mentioning

confidence: 99%

Current views in HTLV-I-associated adult T-cell leukemia/lymphoma

Nicot

2005

Am. J. Hematol.

103

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Epidemiological studies have demonstrated that the relative percentage of malignant lymphoid proliferations varies widely according to geographical location and ethnic populations. HTLV-I is the etiological agent of adult T-cell leukemia/lymphoma (ATLL) and is also associated with cutaneous T-cell lymphoma (CTCL). However, a definite role of HTLV-I in mycosis fungoides (MF) and/or Sezary syndrome (SS) remains controversial. While most HTLV-I-infected individuals remain asymptomatic carriers, 1-5% will develop ATLL, an invariably fatal expansion of virus-infected CD4 + T cells. This low incidence and the long latency period preceding occurrence of the disease suggest that additional factors are involved in development of ATLL. In this review, diagnosis, clinical features, and molecular pathogenesis of HTLV-I are discussed. Am.

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Frequent expression of CCR4 in adult T-cell leukemia and human T-cell leukemia virus type 1–transformed T cells

Cited by 273 publications

References 48 publications

Clinical significance of CADM1/TSLC1/IgSF4 expression in adult T-cell leukemia/lymphoma

Clinical significance of CADM1/TSLC1/IgSF4 expression in adult T-cell leukemia/lymphoma

Chemokines in tumor development and progression

Current views in HTLV-I-associated adult T-cell leukemia/lymphoma

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