Frequent detection of HIV-and Ig-specific IgM and IgA antibodies in HIV-positive cord-blood sera

Schüpbach, Jörg; Wunderli, Werner; Kind, Christian; Kernen, Rahel; Baumgartner, Antonietta; Tomasik, Zuzana

doi:10.1097/00002030-198909000-00005

Cited by 22 publications

(9 citation statements)

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“…In the largest of these, positive HIV-specific IgA responses in infant serum were extremely low, ranging from undetectable to less than 0·5% [30,33]. Other smaller studies have detected HIVspecific antibodies in cord blood obtained from uninfected infants born to HIV-infected mothers, which would support low-level diffusion of IgA antibodies; however, this could also represent infant IgA production resulting from HIV-1 exposure in utero, consistent with our current hypothesis [29,31,32].…”

Section: Characteristicsupporting

confidence: 85%

Salivary human immunodeficiency virus (HIV)-1-specific immunoglobulin A in HIV-1-exposed infants in Kenya

Farquhar

VanCott

Bosire

et al. 2008

Clinical and Experimental Immunology

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SummaryHumoral immunity, and specifically immunoglobulin A (IgA) that is directed against human immunodeficiency virus (HIV)-1, may contribute to protection against HIV-1 acquisition at mucosal surfaces. HIV-1-specific IgA has been detected in genital tract secretions of HIV-1-uninfected commercial sex workers with HIV-1 exposure, and may be produced in parotid saliva by infants exposed orally to HIV-1 during delivery and breastfeeding. To explore this hypothesis, we collected saliva from 145 infants aged Յ 6 months enrolled in a perinatal HIV-1 transmission study in Nairobi and from 55 control infants without HIV-1 exposure who were born to HIV-1-seronegative mothers. Among the 145 infants, 115 (79%) remained uninfected during the 12-month study period and 30 (21%) became HIV-1-infected during followup. Nine (8%) of the 115 HIV-1-exposed, uninfected infants had detectable levels of HIV-1 gp160-specific IgA compared with four (13%) of 30 infected infants and none of 55 control infants (P = 0·47 and P = 0·03 respectively). Among the nine HIV-1-exposed, uninfected infants with positive assays, median age was 1 month and none acquired HIV-1 during follow-up. We conclude that HIV-1-specific salivary IgA responses may be generated by very young infants exposed perinatally to maternal HIV-1. Mucosal responses would be an appropriate target for paediatric vaccines against breast milk HIV-1 transmission.

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Section: Characteristicsupporting

confidence: 85%

Salivary human immunodeficiency virus (HIV)-1-specific immunoglobulin A in HIV-1-exposed infants in Kenya

Farquhar

VanCott

Bosire

et al. 2008

Clinical and Experimental Immunology

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“…Table I summarises all data obtained from serum of infected (1-12) and uninfected (13)(14)(15)(16)(17)(18)(19)(20) children.…”

Section: Resultsmentioning

confidence: 99%

Detection of IgA and IgM antibodies to HIV-1 in neonates by radioimmune western blotting.

Portincasa

Conti

et al. 1992

BMJ

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“…tn addition to the detection of anti-HIV-I secretory IgA in various body fluids including saliva, semen, vaginal secretions, tears and breast milk, the presence of IgA antibody to HIV-t has been noted in the serum, both in infants [7][8][9][10][11] and in adults [2,[12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of serum immunoglobulin A antibodies to pol gene products during HIV-1 infection

Quesnel¹,

Pozzetto

Moja³

et al. 1993

Clinical and Experimental Immunology

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SUMMARYSerum specimens from 66 HIV-t-infected subjects were tested by ELISA for the presence of IgA antibodies to HIV-t: 44 samples were found positive and 37 were confirmed by immunoblot. In these subjects, the presence of anti-HIV IgA antibodies was studied in relation to the total count of circulating CD4+ lymphocytes and to the level of serum IgA. A significative correlation {P<0-03) was found between the absence of IgA to the subunit p68 ofthe reverse transcriptase and a count of CD4+ cell < 400/mm^ or total IgA level over 4-25 g//. The same pattern was observed for the IgA antibodies to the p52 subunit but the association was just not significant (/'<007). No significant decrease was noted for the IgA directed towards the other proteins of HIV-1, especially the products of the gag gene.

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Frequent detection of HIV-and Ig-specific IgM and IgA antibodies in HIV-positive cord-blood sera

Cited by 22 publications

References 0 publications

Salivary human immunodeficiency virus (HIV)-1-specific immunoglobulin A in HIV-1-exposed infants in Kenya

Salivary human immunodeficiency virus (HIV)-1-specific immunoglobulin A in HIV-1-exposed infants in Kenya

Detection of IgA and IgM antibodies to HIV-1 in neonates by radioimmune western blotting.

Prognostic value of serum immunoglobulin A antibodies to pol gene products during HIV-1 infection

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