Frequent colocalization of mu opioid and NMDA-type glutamate receptors at postsynaptic sites in periaqueductal gray neurons

Commons, Kathryn G.; Bockstaele, Elisabeth J. Van; Pfaff, Donald W.

doi:10.1002/(sici)1096-9861(19990614)408:4<549::aid-cne8>3.0.co;2-3

Cited by 84 publications

(38 citation statements)

References 54 publications

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“…The PAG contains a high density of mu opioid receptor (MOR) containing neurons [21, 22, 42, 51, 70, 71, 91] and microinjection of opiate antagonists into the PAG significantly attenuates the analgesic effects of systemic morphine [13, 57, 94]. Similarly, administration of morphine, or other mu opioid receptor agonists, into the PAG produces potent analgesia, which is blocked by central or systemic administration of naloxone [46].…”

Section: Neural Correlate Of Sexually Dimorphic Pain and Analgesiamentioning

confidence: 99%

The neuroanatomy of sexual dimorphism in opioid analgesia

Loyd

Murphy

2014

Experimental Neurology

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The influence of sex has been neglected in clinical studies on pain and analgesia, with the vast majority of research conducted exclusively in males. However, both preclinical and clinical studies indicate that males and females differ in both the anatomical and physiological composition of central nervous system circuits that are involved in pain processing and analgesia. These differences influence not only the response to noxious stimuli, but also the ability of pharmacological agents to modify this response. Morphine is the most widely prescribed opiate for the alleviation of persistent pain in the clinic; however, it is becoming increasingly clear that morphine is less potent in women compared to men. This review highlights recent research identifying neuroanatomical and physiological dimorphisms underlying sex differences in pain and opioid analgesia, focusing on the endogenous descending pain modulatory circuit.

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Section: Neural Correlate Of Sexually Dimorphic Pain and Analgesiamentioning

confidence: 99%

The neuroanatomy of sexual dimorphism in opioid analgesia

Loyd

Murphy

2014

Experimental Neurology

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“…These receptors commonly co-localize in cellular profiles in which one or both receptors may be extrasynaptic. Extrasynaptic NMDAR or MOR have been detected in the CeA (NR2B- Lopez de Armentia and Sah, 2003), NTS (MOR: Huang, et al, 2000), PAG (MOR: Commons, et al, 1999), and in the NAc (NR1, MOR: Gracy, et al, 1997). AMPAR and MOR co-localization has also been detected in the BLA (GluR1, MOR: Glass, et al, 2005), hippocampus (GluR1: Billa, et al, 2010), and most recently, in the CeA by Beckerman and Glass (2010).…”

Section: Anatomical Evidence For Glutamate-opioid Interactionsmentioning

confidence: 99%

Unraveling glutamate–opioid receptor interactions using high-resolution electron microscopy: Implications for addiction-related processes

Scavone

Asan

Bockstaele

2011

Experimental Neurology

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Adaptive responses in glutamate and opioid receptor systems in limbic circuits are emerging as a critical component of the neural plasticity induced by chronic use of abused substances. The present commentary reviews findings from neuroanatomical studies, with superior spatial resolution, that support a cellular basis for prominent interactions of glutamate and opioid receptor systems in preclinical models of drug addiction. The review begins by highlighting the advantages of high-resolution electron microscopic immunohistochemistry for unraveling receptor interactions at the synapse. With an emphasis on a recent publication describing the anatomical relationship between the μ-opioid receptor (MOR) and the AMPA-GluR2 subunit by Beckerman and Glass (2010), we review the anatomical evidence for opioid-induced neural plasticity of glutamate receptors in selected brain circuits that are key integrative substrates in the brain's motivational system. The findings stress the importance of glutamate-opioid interactions as important neural mediators of adaptations to chronic use of abused drugs, particularly within the amygdaloid complex.

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“…At the ultrastructural level, MOR and NMDAR co-localize convincingly [22]. Specifically, the mesencephalic PAG is densely innervated by glutamatergic projections from the forebrain and these receptors co-localize robustly in the dendrites and somata of ventrolateral PAG neurons [10,23]. The localization of MORs in the postsynapse is reflected by its modulation by spinophilin (neurabin II) [24,25], a marker of dendritic spines [26].…”

Section: Introductionmentioning

confidence: 98%