Frequency, spectrum and occupational relevance of type IV allergies to rubber chemicals

Hintzenstern, Jutta v.; Heese, Angelika; Koch, H.; Peters, K.‐P.; Hornstein, O. P.

doi:10.1111/j.1600-0536.1991.tb01717.x

Cited by 114 publications

(48 citation statements)

References 14 publications

(19 reference statements)

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“…The latter is a cell-mediated immune reaction in the skin that usually results from a hypersensitivity to one of the numerous chemicals added during processing (von Hintzenstern et al 1991;Wyss et al 1993), and it is rarely associated with systemic manifestations. However, patients with delayed-type hypersensitivity reactions are at greater risk of developing immediate reactions due to skin breakdown and resultant increased exposure to NRL (Charous et al 1994;.…”

Section: Discussionmentioning

confidence: 99%

Latex allergy and occupational asthma in health care workers: adverse outcomes.

Amr

Bollinger²

2004

Environ Health Perspect

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The prevalence of natural rubber latex (NRL) allergy has been estimated to be 5-18% in health care workers, and latex exposure has been one of the leading causes of occupational asthma in the last several years. We present the cases of two nurses who developed sensitivity to NRL, both with dermatologic symptoms and respiratory symptoms that included asthma. They were referred to the University of Maryland for evaluation of their allergies, then for occupational and environmental consults. The patients' allergy to NRL was confirmed on the basis of clinical history, a positive skin test to latex, and the presence of latex-specific immunoglobulin E (IgE) serology by radioallergosorbent test (RAST). Both patients worked in the same community hospital for approximately 20 years; one was an endoscopy nurse and the other worked in the emergency department. Following the diagnosis of allergy to latex, both patients avoided direct skin contact with latex, but they continued to work in the same respective environments, where powdered latex gloves and other potentially sensitizing chemicals were used. Instead of improving, the clinical condition of the patients worsened and they remained symptomatic, even after they were removed from their workplace. Their airways reacted to low levels of a variety of sensitizers and irritants in the environment, and they became depressed. Both nurses were referred for vocational rehabilitation.

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Section: Discussionmentioning

confidence: 99%

Latex allergy and occupational asthma in health care workers: adverse outcomes.

Amr

Bollinger²

2004

Environ Health Perspect

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“…9 O grupo tiuram é o principal sensibilizante presente nas luvas de borracha, tanto de uso hospitalar quanto doméstico e industrial. 10,11,12 A associação de dermatite alérgica de contato e urticária de contato, no mesmo indivíduo, é ocorrência de difícil diagnóstico e pouco frequente, mas presente em alguns relatos da literatura, principalmente os que focalizam profissionais da saúde. Num desses estudos, observou-se que 33 (61%) dos 55 trabalhadores de um hospital tinham dermatite de contato por irritante primário (DCIP), 17 (31%) dermatite alérgica de contato (DAC) e 14 (27%) urticária de contato (UC).…”

Section: Discussionunclassified

Associação de urticária de contato e dermatite alérgica de contato à borracha

Fernadez¹,

Canosa²,

Lazzarini

et al. 2009

An. Bras. Dermatol.

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Resumo: Apresenta-se o caso de uma profissional da área da saúde que desenvolveu reação de hipersensibilidade dos tipos I e IV à borracha. O quadro clínico mostrava dermatite eczematosa no dorso das mãos. O teste de contato foi positivo para o grupo tiuram, assim como o teste aberto com fragmento de luva após exposição de 20 minutos. A dosagem de IgE sérica (Rast) mostrou-se relevante. As reações aos alérgenos da borracha são frequentes entre os profissionais da saúde, devido ao contato constante com esse material. Palavras-chave: Borracha; Dermatites alérgicas de contato; Dermatite ocupacional; Hipersensibilidade ao látex; Látex; Luvas cirúrgicas; Urticária Abstract: We present a case of a healthcare professional that developed type I and IV hypersensitivity reactions to rubber. During the clinical examination the patient showed eczematous dermatitis of the hands. The patch test was positive for thiuram group and an open test with a piece of glove was positive after 20 minutes of exposure. Allergen-specific IgE test (RAST) was relevant. Reactions to rubber allergens are frequent among healthcare professionals due to constant contact with this material.

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“…In der Konzentration von 1 mM (Inkubationszeit 3 Tage) wirkt 2-Mercaptobenzothiazol bei Ehrlich-Aszites-Tumor-Zellen stark zytotoxisch, während 10 mM die Überlebensrate der Zellen nicht beeinträchtigten (Takamura et al, 1989 (Kayser und Schlede, 1995;Klaschka und Voßmann, 1995 (Edman, 1991;Foussereau und Cavelier, 1977;von Hintzenstern et al, 1991), und bei Latexprodukten auch gegenüber Naturlatex (Hevea brasiliensis; Groß, 1990;Guimaraens et al, 1992). Die Mehrzahl der Patienten reagierte, soweit geprüft, auch gegenüber Mercapto-Mix bzw.…”

Section: Sonstige Wirkungenunclassified

2‐Mercaptobenzothiazol (2‐(3H)‐Benzothiazolthion) [MAK Value Documentation in German language, 1999]

2012

The MAK‐Collection for Occupational Health and Safety

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Frequency, spectrum and occupational relevance of type IV allergies to rubber chemicals

Cited by 114 publications

References 14 publications

Latex allergy and occupational asthma in health care workers: adverse outcomes.

Latex allergy and occupational asthma in health care workers: adverse outcomes.

Associação de urticária de contato e dermatite alérgica de contato à borracha

2‐Mercaptobenzothiazol (2‐(3H)‐Benzothiazolthion) [MAK Value Documentation in German language, 1999]

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