Frequency‑Specific Regional Homogeneity Alterations and Cognitive Function in Obstructive Sleep Apnea Before and After Short-Term Continuous Positive Airway Pressure Treatment

Li, Haijun; Lan, Li; Kong, Linghong; Li, Panmei; Zeng, Yaping; Li, Kunyao; Xie, Wei; Shu, Yongqiang; Liu, Xiang; Peng, Dechang

doi:10.2147/nss.s344842

Cited by 17 publications

(20 citation statements)

References 53 publications

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“…45 Additionally, another study and our previous study reported that patients with OSA showed decreased ReHo in the superior frontal gyrus that was correlated with cognitive impairment, which partially overlaps with our findings. 20,46 Similar to these studies, we found that the PerAF values in the left superior frontal gyrus were positively correlated with the MoCA scores in orientation, suggesting that OSA-induced functional abnormalities in the left superior frontal gyrus may be associated with abnormalities in the DMN or other cognitive networks, and the exact association is yet to be further confirmed.…”

Section: Difference In Peraf Between Patients With Osa and Hcssupporting

confidence: 80%

“…38,39 However, some studies have suggested that changes in resting-state brain activity in OSA patients are caused by OSA itself rather than obesity. 17,20 Nevertheless, in this study we included BMI as a covariate to mitigate its effect, and thus, we hypothesized that although there was a difference in BMI between OSA patients and healthy controls, this change was caused by OSA rather than obesity. The present study showed that patients with OSA had higher ESS scores and lower stage 3 + 4 sleep and REM sleep, indicating that these patients are more likely to experience daytime sleepiness due to poor sleep efficiency.…”

Section: Discussionmentioning

confidence: 99%

“…Our previous studies revealed that patients with OSA exhibit altered spontaneous brain activity, especially altered regional homogeneity (ReHo) values, in the frontal lobes and DMN. 19,20 However, these results were not always consistent. The location of aberrant regional spontaneous brain activity in patients with OSA during the resting state and its correlations with behavioral performance are critical.…”

Section: Introductionmentioning

confidence: 94%

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Abnormal Spontaneous Brain Activity and Cognitive Impairment in Obstructive Sleep Apnea

Xie¹,

Shu²,

Liu³

et al. 2022

NSS

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This study aimed to explore the alterations in spontaneous brain activity in obstructive sleep apnea (OSA) using percent amplitude of fluctuation (PerAF) and investigate the relationship between abnormal spontaneous brain activity and cognitive impairment in OSA. Patients and Methods: Overall, 52 patients with moderate to severe OSA and 61 healthy controls (HCs) were eventually enrolled in this study. All participants underwent resting-state functional magnetic resonance (rs-fMRI) and T1-weighted imaging. The PerAF was calculated and compared between patients with OSA and HCs, with voxel level P < 0.001 and cluster level P < 0.05 corrected with Gaussian Random Field was be considered statistically different. A partial correlation analysis was used to assess the relationship between altered PerAF and clinical assessments in patients with OSA. Results: Compared to HCs, patients with OSA had significantly lower PerAF values in the right rectal gyrus and left superior frontal gyrus, but higher PerAF values in the right cerebellum posterior lobe and left middle frontal gyrus. The PerAF values of some specific regions in patients with OSA correlated with sleep efficiency and Montreal Cognitive Assessment scores. Additionally, support vector machine analysis showed that PerAF values in all differential brain regions could differentiate patients with OSA from HCs with good accuracy. Conclusion: Specific brain areas in OSA patients may exhibit aberrant neuronal activity, and these anomalies may be linked to decreased cognitive performance. This discovery offers fresh perspectives on these patients' neurocognition.

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Section: Difference In Peraf Between Patients With Osa and Hcssupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

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Abnormal Spontaneous Brain Activity and Cognitive Impairment in Obstructive Sleep Apnea

Xie¹,

Shu²,

Liu³

et al. 2022

NSS

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“…Park et al ( 46 ) found that OSA showed decreased network integration connectivity in the cerebellum, which was susceptible to hypoxia or ischemia. After long-term CPAP treatment, patients with OSA may have increased cerebellar volume ( 47 , 48 ). In our study, even one-night CPAP treatment can reverse the brain function of the cerebellum.…”

Section: Discussionmentioning

confidence: 99%

Aberrant amplitude of low-frequency fluctuations in different frequency bands and changes after one-night positive airway pressure treatment in severe obstructive sleep apnea

et al. 2022

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ObjectiveThis study was aimed to investigate the characteristics of the amplitude of low-frequency fluctuation (ALFF) at specific frequencies in severe obstructive sleep apnea (OSA) patients. A comparison was made between pre-CPAP treatment and one night after continuous positive airway pressure (CPAP) treatment.Methods30 severe OSA patients and 19 healthy controls (HC) were recruited. The ALFF method was used to assess the local features of spontaneous brain activity and calculated at different bands (slow-5 and slow-4). A correlation analysis was performed to evaluate the relationship between the changes of the ALFF and polysomnography data.ResultsCompared with HC, in slow-5 frequency band, OSA patients showed significantly decreased ALFF in the left inferior temporal gyrus, and significantly increased ALFF in the left middle frontal gyrus, left inferior frontal gyrus, triangular part, right superior frontal gyrus, dorsolateral and right middle temporal gyrus. In slow-4 frequency, there was significantly decreased ALFF in the right inferior temporal gyrus, and significantly increased ALFF in the left precuneus, right posterior cingulate gyrus and right median cingulate besides the slow-5 difference band showed. Compared with pre-CPAP, we found that after CPAP treatment, ALFF signals in the left insula in slow-5 and left caudate in slow-4 increased, but the calcarine in slow-4 significantly reduced. Correlation analysis showed that the left angular slow-4 band change was positively correlated with the slow wave sleep change (r = 0.4933, p = 0.0056). The left cerebellum 6 slow-5 band change was positively correlated with the duration of the REM sleep change (r = 0.4563, p = 0.0113), and the left cerebellum 6 slow-4 band change was also positively correlated with the mean blood oxygen change in the REM (r = 0.4591, p = 0.0107) and NREM sleep (r = 0.4492, p = 0.0128).ConclusionWe found that the use of slow-4 was more specific in OSA studies. These results suggested that the severe OSA patients have frequency-related abnormal spontaneous neural activity, which may contribute to a better understanding of the pathological basis of OSA-related diseases and provide a potential therapeutic target for OSA patients.

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“…Our previous study showed that after 1 month of CPAP treatment, spontaneous brain activity in the bilateral posterior cerebellar lobe, right superior temporal gyrus, left anterior central gyrus, and other brain regions was reversed, which was related to cognitive function and drowsiness. Such reversible spontaneous brain activity is related to the adaptive compensation of OSA ( 13 ). However, few studies were conducted on whether WM structure is reversed after CPAP therapy.…”

Section: Introductionmentioning

confidence: 99%

Effects of 3-month CPAP therapy on brain structure in obstructive sleep apnea: A diffusion tensor imaging study

et al. 2022

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White matter (WM) fiber alterations in patients with obstructive sleep apnea (OSA) is associated with cognitive impairment, which can be alleviated by continuous positive airway pressure (CPAP). In this study, we aimed to investigate the changes in WM in patients with OSA at baseline (pre-CPAP) and 3 months after CPAP adherence treatment (post-CPAP), and to provide a basis for understanding the reversible changes after WM alteration in this disease. Magnetic resonance imaging (MRI) was performed on 20 severely untreated patients with OSA and 20 good sleepers. Tract-based spatial statistics was used to evaluate the fractional anisotropy (FA), mean diffusion coefficient, axial diffusion coefficient, and radial diffusion coefficient (RD) of WM. To assess the efficacy of treatment, 20 patients with pre-CPAP OSA underwent MRI again 3 months later. A correlation analysis was conducted to evaluate the relationship between WM injury and clinical evaluation. Compared with good sleepers, patients with OSA had decreased FA and increased RD in the anterior thalamic radiation, forceps major, inferior fronto-occipital tract, inferior longitudinal tract, and superior longitudinal tract, and decreased FA in the uncinate fasciculus, corticospinal tract, and cingulate gyrus (P < 0.05). No significant change in WM in patients with post-CPAP OSA compared with those with pre-CPAP OSA. Abnormal changes in WM in untreated patients with OSA were associated with oxygen saturation, Montreal cognitive score, and the apnea hypoventilation index. WM fiber was extensively alteration in patients with severe OSA, which is associated with cognitive impairment. Meanwhile, cognitive recovery was not accompanied by reversible changes in WM microstructure after short-term CPAP therapy.

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Frequency‑Specific Regional Homogeneity Alterations and Cognitive Function in Obstructive Sleep Apnea Before and After Short-Term Continuous Positive Airway Pressure Treatment

Cited by 17 publications

References 53 publications

Abnormal Spontaneous Brain Activity and Cognitive Impairment in Obstructive Sleep Apnea

Abnormal Spontaneous Brain Activity and Cognitive Impairment in Obstructive Sleep Apnea

Aberrant amplitude of low-frequency fluctuations in different frequency bands and changes after one-night positive airway pressure treatment in severe obstructive sleep apnea

Effects of 3-month CPAP therapy on brain structure in obstructive sleep apnea: A diffusion tensor imaging study

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