Frequency selectivity of phase-locking of complex sounds in the auditory nerve of the rat

Møller, Aage R.

doi:10.1016/0378-5955(83)90062-x

Cited by 43 publications

(7 citation statements)

References 35 publications

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“…7 (c) ]. Similar behavior is observed in recorded isointensity responses of auditory nerve fibers using average rate measures of the activity (Kiang, 1980;Moller, 1983a).…”

Section: The Magnitude Of the Fundamental Is A[ 1 Q-(07') 2 ] --1/2/(supporting

confidence: 71%

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A biophysical model of cochlear processing: Intensity dependence of pure tone responses

et al. 1986

The Journal of the Acoustical Society of America

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A mathematical model of cochlear processing is developed to account for the nonlinear dependence of frequency selectivity on intensity in inner hair cell and auditory nerve fiber responses. The model describes the transformation from acoustic stimulus to intracellular hair cell potentials in the cochlea. It incorporates a linear formulation of basilar membrane mechanics and subtectorial fluid-cilia displacement coupling, and a simplified description of the inner hair cell nonlinear transduction process. The analysis at this stage is restricted to low-frequency single tones. The computed responses to single tone inputs exhibit the experimentally observed nonlinear effects of increasing intensity such as the increase in the bandwidth of frequency selectivity and the downward shift of the best frequency. In the model, the first effect is primarily due to the saturating effect of the hair cell nonlinearity. The second results from the combined effects of both the nonlinearity and of the inner hair cell low-pass transfer function. In contrast to these shifts along the frequency axis, the model does not exhibit intensity dependent shifts of the spatial location along the cochlea of the peak response for a given single tone. The observed shifts therefore do not contradict an intensity invariant tonotopic code.

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“…7 (c) ]. Similar behavior is observed in recorded isointensity responses of auditory nerve fibers using average rate measures of the activity (Kiang, 1980;Moller, 1983a).…”

Section: The Magnitude Of the Fundamental Is A[ 1 Q-(07') 2 ] --1/2/(supporting

confidence: 71%

“…One such phenomenon concerns the nonlinear dependence of the frequency selectivity of phase locking on stimulus intensity in the auditory nerve to simple and complex sounds (Moller, 1983a;Evans, 1977;Smoorenburg and Linschote n, 1978).…”

Section: Introductionmentioning

confidence: 99%

A biophysical model of cochlear processing: Intensity dependence of pure tone responses

et al. 1986

The Journal of the Acoustical Society of America

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“…The Fourier transform magnitude of FSVs also shows a change, toward lower frequencies, in the frequency associated with the peak amplitude. Using revcor functions, Møller (1983) showed similar effects as a result of increasing stimulus level in the responses to noise of ANFs in the rat. Kim and Young (1994) found similar effects in the cat, Changes in near-CF group delays were also observed as a function of stimulus level.…”

Section: Second-order Wiener Kernelsmentioning

confidence: 80%

Analysis of responses to noise in the ventral cochlear nucleus using Wiener kernels

Recio-Spinoso

Dijk

2006

Hearing Research

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“…It has been known for decades that when the mammalian ear is stimulated by sound with precisely defined frequency (pure tones, up tõ 3.5 or 5.0 kHz depending on the species) the firing activity on the auditory nerve is cyclically and precisely concentrated only in one-half of the stimulating sinusoid, a phenomenon known as phase locking (1,112). But rat IHCs, maintained at room temperature (19-22°C) at a potential of -80 mV, show level-dependent fast adaptation with shortest A of ~0.5 ms (for the smallest stimuli in 1.5 mM [Ca 2+ ] o , both at the 4-and 14-kHz frequency points sampled in this study (6).…”

Section: + Modulation Of Mechanotransduction In Hair Cellsmentioning

confidence: 99%

Ca²⁺ Signaling in the Inner Ear

Mammano

Bortolozzi²,

Ortolano

et al. 2007

Physiology

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Sensory transduction in the inner ear (FIGURE 1) is the job of hair cells that are grouped into three types of sensory epithelia. The organ of Corti is the epithelium of the mammalian cochlea (hearing); the maculae and the cristae are the epithelia of the vestibular system (balance). The epithelia are polarized in that sensory hair cells as well as nonsensory (supporting) cells are divided into apical and basolateral domains. Diffusion of proteins between these subcellular domains is prevented by tight junctions between neighboring cells, which also serve to insulate endolymph, an extracellular fluid low in Na + and Ca 2+ but rich in K + , from perilymph, the normal extracellular fluid that bathes the basolateral membrane of the cells (FIGURE 1A).Mechanical stimuli that can be ultimately ascribed to sound, for the cochlea, or acceleration, for the vestibular system, are applied to the hair cell mechanoreceptor organelle, composed of 20-300 actin-filled stiff microvilli, called the stereocilia, that reach into endolymph from the cell's apical surface and are arranged in three to four rows of increasing height. Stimulation of sensory transduction results in an increased flux of K + from endolymph through the hair cells, for hair bundle deflection modulates the open probability of specialized cation-selective mechanosensitive transduction (MET) channels found in the stereocilia (FIGURES 1A AND 2A). By altering the ratio of apical to basolateral membrane impedance, MET channel opening (closing) decreases (increases) the potential difference across the basolateral membrane of the hair cell. The ensuing graded receptor potential (i.e., the analog modulation of the hair cell resting potential) follows the movements of the stereocilia. Electrical activity in the hair cell is signaled to the central nervous system by afferent fibers of the acoustic or vestibular nerve that synapse to several active zones in the cell basolateral membrane.With few exceptions, hair cells of the vestibular system in all animals respond to subacoustic frequencies, rarely in excess of a few tens of Hertz, whereas distinct mechanisms have evolved in the auditory periphery to extract sound frequency information over a far broader range. Thus, in the mammalian cochlea primed by sound, hydromechanical interactions excite specific vibration patterns on the basilar membrane, the elastic structure that supports the organ of Corti (FIGURE 1A).Basilar membrane vibrations are enhanced by a physiologically vulnerable mechanism, known as the cochlear amplifier, permitting frequency discrimination with ~1% accuracy over a range that, in humans, covers seven octaves from 40 Hz to 18 kHz. Frequency limits are species specific, and in other mammals the upper boundary may extend beyond a dazzling 100 kHz. In a subset of these frequencies, what might rightfully be defined as the energetic miracle of sound perception enables the detection of just-audible sounds corresponding to pressure changes as small as ~20 Pa (hearing threshold), i.e., 1 part in 5 ϫ 10 9 of ...

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Frequency selectivity of phase-locking of complex sounds in the auditory nerve of the rat

Cited by 43 publications

References 35 publications

A biophysical model of cochlear processing: Intensity dependence of pure tone responses

A biophysical model of cochlear processing: Intensity dependence of pure tone responses

Analysis of responses to noise in the ventral cochlear nucleus using Wiener kernels

Ca²⁺ Signaling in the Inner Ear

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Frequency selectivity of phase-locking of complex sounds in the auditory nerve of the rat

Cited by 43 publications

References 35 publications

A biophysical model of cochlear processing: Intensity dependence of pure tone responses

A biophysical model of cochlear processing: Intensity dependence of pure tone responses

Analysis of responses to noise in the ventral cochlear nucleus using Wiener kernels

Ca2+ Signaling in the Inner Ear

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Product

Resources

About

Ca²⁺ Signaling in the Inner Ear