Frequency, Predictors, Etiology, and Outcomes for Deep Intracerebral Hemorrhage without Hypertension

Prats‐Sánchez, Luís; Iruzubieta, Pablo; Vesperinas, Ana; Collet, R.; Martínez‐Domeño, Alejandro; Guisado‐Alonso, Daniel; Camps‐Renom, Pol; Delgado‐Mederos, Raquel; Guasch‐Jiménez, Marina; Ramos‐Pachón, Anna; Rodríguez‐Antigüedad, Jon; Campo‐Caballero, David; Equiza, Jon; Riva, Patricia de la; Martínez-Zabaleta, Maite; Arce, Ana de; Martí‐Fàbregas, Joan

doi:10.1016/j.jstrokecerebrovasdis.2021.106293

Cited by 1 publication

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“…Interestingly, in long-term FU OW patients do not show higher mortality as potentially thought, especially considering secondary sequelae such as coronary artery disease as well as type 2 diabetes. 16 These findings (Figure 2) are in line with the short-term data of Persaud. 4 In our cohort, only patients aged up to 80 years were analyzed.…”

Section: Discussionsupporting

confidence: 86%

The Impact of Body-Mass-Index on Functional Outcomes and Bleeding Volumes in Patients Suffering Non-Traumatic Intracerebral Haemorrhage

Wanderer,

Saemann,

Grüter

et al. 2023

Preprint

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The association between obesity and clinical as well as radiological outcomes in patients suffering non-traumatic intracerebral haemorrhage (ICH) remains unclear. The obesity paradox suggests a protective effect regarding in-hospital mortality. This study evaluates the impact of body mass index (BMI) on functional long-term outcome and bleeding volume in patients with non-traumatic ICH. A retrospective cohort study including all consecutive patients with spontaneous ICH treated at a tertiary referral centre between December 2017 and June 2021, aged 80 years or younger (n = 218), were included. Patients were dichotomized into overweight (OW, BMI ≥ 25 kg/m2) and normal weight (NW, BMI < 25 kg/m2). Functional outcomes were assessed by the modified Rankin scale (mRS), extended Glasgow Outcome Scale (GOS-E) and the National Institutes of Health Stroke Scale score (NIHSS) at 1, 3, 6 and 12-months follow-up. Bleeding volumes were calculated as ABC/2. Univariate and multivariate analysis were performed to assess clinical predictors of favourable outcome in the long-term. Of 218 patients (66.04 ± 15.18 years) suffering non-traumatic ICH, 115 (52.75%) were OW (29.72 ± 3.82). Female sex (p = 0.1), NIHSS (p = 0.69), cardiovascular risk factors (p = 0.55), ICH volume (p = 0.19), and presence of anticoagulation (p = 0.67) did not significantly differ between the OW and NW cohort. At discharge, functional outcome did not significantly differ between both cohorts (NW, mRS 3.92 ± 2.54 vs. OW, mRS 3.21 ± 2.43, (p = 0.28)). Multivariate analysis revealed that haemorrhage volume (p = 0.01) was the only robust risk factor to predict functional outcome after 1 year. Our data suggests that in ICH patients, neither obesity nor patient’s age are negative predictors for functional outcome in the long-term. Instead, bleeding volume is a robust risk factor predicting poor functional status after ICH. Therefore, prospective randomized trials analysing this coherence are highly warranted.

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Section: Discussionsupporting

confidence: 86%