Frequency of Vitamin D Deficiency in Patients with Liver Cirrhosis

Abstract

Objective: To determine the frequency of vitamin D deficiency among liver cirrhosis patients and presented at Isra university hospital Hyderabad Study design: Cross-sectional Study setting: Gastroenterology department of Isra university Hospital, Hyderabad Sind Pakistan Study duration: January 2018 to July 2018 All patients with age between 30 and 60 years, both genders and having evidence of cirrhosis of liver were selected in the study. Disease severity was evaluated by the Child–Pugh’s classification. For the assessment of vitamin D levels, the blood samples from all patients were sent to the diagnostic laboratory. During the hospital stay and subsequent follow-up visits, the patients were monitored. All the data were collected via study proforma for the purpose of analysis. Results: A total of 120 cases of liver cirrhosis were studied, their average age was 50.58+5.15 years. Males were commonest 55.0% compared to females 45.0%. Hepatitis C was the most common etiological factor 65.8%. Child–Pugh grade C was most common 57.5%. Mean of the vitamin D level was 19.16+ 6.74 ng/ml. Almost all patients were with vitamin D deficiency as 90.0%. Vitamin D deficiency was significantly associated to the old age, HCV, alcoholic and fatty liver disease (p-<0.05), while statistically insignificant according to gender (p-0.142). Conclusion: It was concluded that the deficiency of vitamin D was highly prevalent 90.0%. It was significantly linked to the HCV, age and alcoholic hepatic disease. Key words: Liver cirrhosis, vitamin D

Association between serum vitamin D status and severity of liver cirrhosis: Implications for therapeutic targeting in Nigerian patients

“…[9][10][11] Furthermore, vitamin D de ciency has been linked to an increased risk and progression of various chronic diseases, including liver cirrhosis. [12,13] Vitamin D de ciency is highly prevalent in patients with chronic liver disease regardless of the aetiology, [14,15] and is known to be associated with severe liver disease and mortality. [16] Several studies have investigated the association between serum vitamin D levels and liver cirrhosis, and many have reported lower serum vitamin D levels in patients with liver cirrhosis compared to healthy individuals.…”