Frequency of Vitamin D Deficiency in Newly Diagnosed Type 2 Diabetes Mellitus Patients

Bashir, Zara-tul-ain; Amjad, Huma; Gilani, Syed Tanveer Abbas; Khan, Amjad; Riaz, Syeda Urooj; Medical, Jinnah

doi:10.21089/njhs.33.0083

Cited by 2 publications

(1 citation statement)

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“…These symptoms, often insidious in onset, contribute to the diagnostic challenge associated with osteomalacia, necessitating a comprehensive understanding of its intricate interplay with vitamin D deficiency. 8,9 In literature exploration of osteomalacia and vitamin D deficiency, the focus lies on unraveling the symbiotic relationship between these entities, emphasizing the critical role of vitamin D in skeletal health and the far-reaching consequences of its inadequacy. A nuanced comprehension of this dynamic interplay is imperative for clinicians, researchers, and healthcare providers as they navigate the landscape of prevention, diagnosis, and management of osteomalacia.…”

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confidence: 99%

Frequency of Osteomalacia and Vitamin D Deficiency in Elderly Patient Presenting at a Tertiary Care Hospital

Khan,

Babar

et al. 2024

PJMHS

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Introduction: Vitamin D deficiency leads to the bone hypomineralization condition known as osteomalacia in peoples and is linked to other non-skeletal diseases. Objectives: To determine the frequency of osteomalacia and vitamin d deficiency in elderly patient presenting at a tertiary care hospital. Study Design: Cross sectional study Settings: Department of Diabetes and endocrinology Hayatabad medical complex Peshawar Materials & Methods: Total 140 patients aged 50 years and above presenting with body pain and weakness who required medical treatment at hospital for various health concerns. Patients with known metabolic bone disorders other than osteomalacia, patients receiving vitamin D supplementation or specific treatments for bone disorders were excluded. Participants underwent a thorough clinical assessment, including medical history review, physical examination, and assessment of musculoskeletal symptoms associated with osteomalacia. Blood samples were collected to measure serum levels of 25-hydroxyvitamin D [25(OH)D], the biomarker for vitamin D status. Additional biochemical markers, such as alkaline phosphatase and parathyroid hormone levels, were also assessed to aid in the diagnosis of osteomalacia. Collected data of study variables were analyzed using statistical software (SPSS version 25). Results: Regarding gender, a total of 60 patients were male, constituting 42.85% of the population, while 80 patients were female, representing 57.14%. Musculoskeletal pain was reported in 80 individuals, representing 57.1% of the population. Proximal muscle weakness was observed in 50 patients, accounting for 35.7%. Additionally, 40 patients (28.6%) had a history of fractures. Vitamin D deficiency was identified in 68(48.57%), while osteomalacia was in 11(7.85%) patients. Practical Implication: Understanding the interplay between thyroid disorders and bone health can guide more comprehensive management strategies in this vulnerable population at tertiary care hospitals. Conclusion: In conclusion, our study reveals a relatively high prevalence of biochemical osteomalacia 7.85% among Pakistani old age patients challenging previous estimates in other populations Keywords: Association, Bone Hypomineralization, Non-skeletal Disorders, Osteomalacia, Vitamin D Deficienc

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Section: Introductionmentioning

confidence: 99%

Frequency of Osteomalacia and Vitamin D Deficiency in Elderly Patient Presenting at a Tertiary Care Hospital

Khan,

Babar

et al. 2024

PJMHS

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Vitamin D deficiency and its associated factors among patients with type 2 diabetes mellitus: a systematic review and meta-analysis

Taderegew,

Woldeamanuel,

Wondie

et al. 2023

BMJ Open

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ObjectiveThe study intended to assess the pooled prevalence of vitamin D deficiency (VDD) and its associated factors among patients with type 2 diabetes mellitus (T2DM).DesignThe Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were employed to plan and conduct this systematic review and meta-analysis.Data sourcesPubMed, Medline, Google Scholar, Web of Science, Science Direct and the Worldwide Science database were searched from their inception to 31 January 2023.MethodsData were extracted using a standardised data extraction format prepared in Microsoft Excel. The inverse variance (I2) test was used to evaluate the presence of heterogeneity across the included studies. To identify the possible source of heterogeneity, subgroup analysis was carried out. Funnel plot symmetry, Begg’s and Egger’s tests were used to evaluate the existence of publication bias. In addition, factors associated with VDD among patients with T2DM were examined. All statistical analyses were carried out with STATA V.14 software.ResultsA total of 54 studies with 38 016 study participants were included in the study. The pooled prevalence of VDD among patients with T2DM was found to be 64.2% (95% CI 60.6% to 67.8%) with a substantial level of heterogeneity (I2=98.2%; p<0.001). Results of the subgroup analysis indicated that the pooled prevalence of VDD among patients with T2DM was highest (70.9%) in African nations and lowest (57.1%) in Middle East countries. Being female (pooled OR (POR) 1.60, 95% CI 1.29 to 1.97), having poor glycaemic control (POR 2.50; 95% CI 1.74 to 3.59), hypertension (POR 1.21; 95% CI 1.08 to 1.36), obesity (body mass index ≥25) (POR 1.68; 95% CI 1.16 to 2.44), dyslipidaemia (POR 2.54, 95% CI 1.37 to 4.73), albuminuria (POR 2.22, 95% CI 1.71 to 2.95), nephropathy (POR 1.58; 95% CI 1.08 to 2.31) and retinopathy (POR 1.48: 95% CI 1.17 to 1.89) were predictors of VDD among patients with T2DM.ConclusionsMore than half of patients with T2DM were suffering from VDD. Being female, having poor glycaemic control, hypertension, obesity, dyslipidaemia, albuminuria, nephropathy and retinopathy were the predictors of VDD among patients with T2DM.

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Frequency of Vitamin D Deficiency in Newly Diagnosed Type 2 Diabetes Mellitus Patients

Abstract: Objective: To determine the frequency of vitamin D deficiency in newly diagnosed patients of type 2 diabetes mellitus.

Cited by 2 publications

References 13 publications

Frequency of Osteomalacia and Vitamin D Deficiency in Elderly Patient Presenting at a Tertiary Care Hospital

Frequency of Osteomalacia and Vitamin D Deficiency in Elderly Patient Presenting at a Tertiary Care Hospital

Vitamin D deficiency and its associated factors among patients with type 2 diabetes mellitus: a systematic review and meta-analysis

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