Frequency of Venous Thromboembolism in Patients with Liver Cirrhosis

Abstract

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EASL Clinical Practice Guidelines on prevention and management of bleeding and thrombosis in patients with cirrhosis

“…In patients with cirrhosis admitted to hospital, the incidence of VTE has been reported to be between 1.2% to 7%. 187,266,267 During hospital stay, the occurrence of VTE fluctuates widely, occurring in 0.5% to 7% of patients with chronic advanced liver disease. [267][268][269][270][271] In the setting of hospitalised patients, data from a meta-analysis indicate that about 1% of patients with liver diseases develop or are diagnosed with VTE during their hospitalisation.…”

“…187,266,267 During hospital stay, the occurrence of VTE fluctuates widely, occurring in 0.5% to 7% of patients with chronic advanced liver disease. [267][268][269][270][271] In the setting of hospitalised patients, data from a meta-analysis indicate that about 1% of patients with liver diseases develop or are diagnosed with VTE during their hospitalisation. 272 However, there are apparently contrasting data showing that the overall incidence of VTE in patients with no liver disease, mild liver disease and moderate-severe liver disease was 2.7, 2.4 and 0.9 per 100 patient discharges, respectively.…”

The Pattern of Dyslipidemia in Chronic Liver Disease Patients

“…Several hepatic disorders in which normal liver tissue is replaced by fibrotic tissue are collectively termed chronic liver disease (CLD) [1]. Several metabolic abnormalities are common in CLD like dyslipidemias, 1 2 3 3 4 5 6 7 8 9 clotting factor deficiencies, and in some cases venous thromboembolism due to deficiency of anticoagulation factors [2]. Dyslipidemia is a metabolic anomaly that causes an imbalance in lipids or lipoproteins [3].…”

Portal Vein Thrombosis in Liver Cirrhosis. Part 1: Epidemiology, Pathogenesis, Clinic, Diag-nosis, Impact on Prognosis

“…В популяционных исследованиях было показано, что риск тромботических/тромбоэмболических осложнений при циррозе, по меньшей мере, такой же, как в общей популяции [26]. У госпитализированных пациентов с циррозом частота венозных тромбоэмболий составила 1,2-7 % [31], тогда как у больных без патологии печени либо с легкими и среднетяжелыми видами её патологии венозные тромбоэмболии встретились у 2,7, 2,4 и 0,9 на 100 выписанных пациентов соответственно [32]. По другим данным, риск венозных тромбоэмболий при циррозе увеличен в 1,7 раза по сравнению с больными без цирроза [33], показатели тромбоэмболических событий достигали в этих случаях 561,1 и 249,7 на 10 000 человеко-лет соответственно [34].…”