“…The patients' reluctance to admit to alcohol consumption along with the absence of advanced molecular techniques result in a higher number of false positive cases of cryptogenic cirrhosis in Iran. It is also not quite plausible to conclude that "HH is not a major cause of cryptogenic cirrhosis in the Iranian population" as Jowkar et al have indicated in their study (2). Perhaps, the authors meant to say that the development of cirrhosis in these patients cannot be attributed to HFE mutations.…”
Section: Dear Editormentioning
confidence: 83%
“…In a study by Jowkar et al (2) published in the November issue of Hepatitis Monthly, the C282Y mutation was not detected in cryptogenic cirrhosis patients as well as healthy individuals; however, 22% of the patients and 28% of the healthy individuals were found to be heterozygous for the H63D mutation. Therefore, they concluded that HH is not the major cause of cryptogenic cirrhosis in the Iranian population.…”
“…The patients' reluctance to admit to alcohol consumption along with the absence of advanced molecular techniques result in a higher number of false positive cases of cryptogenic cirrhosis in Iran. It is also not quite plausible to conclude that "HH is not a major cause of cryptogenic cirrhosis in the Iranian population" as Jowkar et al have indicated in their study (2). Perhaps, the authors meant to say that the development of cirrhosis in these patients cannot be attributed to HFE mutations.…”
Section: Dear Editormentioning
confidence: 83%
“…In a study by Jowkar et al (2) published in the November issue of Hepatitis Monthly, the C282Y mutation was not detected in cryptogenic cirrhosis patients as well as healthy individuals; however, 22% of the patients and 28% of the healthy individuals were found to be heterozygous for the H63D mutation. Therefore, they concluded that HH is not the major cause of cryptogenic cirrhosis in the Iranian population.…”
“…Jowkar et al (4), with their interesting study developed in Iran, seem to reinforce the theory that cryptogenic cirrhosis is not associated with iron overload, nor with major HFE mutations. It also appears that there are no geographical differences, since their results are similar to those published in Poland, Europe.…”
Heterozygous C282Y mutation of the HFE gene was associated with liver cirrhosis in the Lithuanian population. In gender-related analysis, heterozygous C282Y and homozygous H63D mutations were linked to liver cirrhosis in men, not in women.
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