Frequency of TLR4 (1063A/G and 1363C/T) polymorphisms in healthy and HIV-infected Omani individuals and their relationship to viral load and T cell count

Said, Elias A.; Alyafei, Fawzia; Zadjali, Fahad; Al-Balushi, Mohammed S.; Hasson, Sidgi S.; Al-Mahroqi, Seham H.; Koh, Crystal Y.; Al-Naamani, Khalid; Al-Busaidi, Juma Zaid; Idris, Mohamed A.; Balkhair, Abdullah; Al-Jabri, Ali A.

doi:10.4238/gmr.15027671

Cited by 5 publications

(4 citation statements)

References 27 publications

(53 reference statements)

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“…[ 43 ] The remaining results of the Vidyant study pointed out TLR4 rs4986790 is associated with stage progression, but not observed in TLR4 rs4986791. [ 52 ] In an Omani cohort, [ 55 ] the relationship between TLR4 (1063A/G, 1363C/T) gene polymorphism and the CD4 and CD8 cell counts and viral load was not found. In the studies of TLR7 gene polymorphisms, Oh et al [ 44 ] showed TLR 7 rs179008 is associated high viral loads and lower baseline CD4 T-cell counts, which was consistent with Anokhin et al, [ 56 ] but inconsistent with Said et al [ 57 ] TLR8 rs3764880 was conferred a significantly protective effect regarding progression of the disease.…”

Section: Resultsmentioning

confidence: 99%

Association of toll-like receptor polymorphisms with acquisition of HIV infection and clinical findings

Shi

Sun³

et al. 2020

Medicine

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Background: To find the relationship between toll-like receptor (TLR) gene variants and human immunodeficiency virus (HIV) infection and clinical findings, which could inform clinical decisions and vaccination strategies. Method: Four databases were searched for articles that were published on or before Jul.1, 2020. Review Manager 5.3 software was applied to perform meta-analysis to explore. Results: A total of 10 studies involving 20 genes, 3697 cases, and 6498 controls were included in this systematic review. TLR2 –196 to –174 Ins/Del (odds ratio [OR] = 1.562; P = .002), TLR4 rs4986790 (OR = 2.05; P = .002), TLR3 rs3775291 (OR = 0.25; P = .03), TLR7 rs179008 ( P = .002), TLR7 rs2074109 (OR = 0.27, P = .019) were found associated with HIV infection. TLR2 –196 to –174, TLR4 rs4986790, TLR7 rs179008, TLR8 rs3764880, TLR9 rs352140 were found associated with clinical findings of HIV infection. We identified 5 case-control studies in meta-analysis, involving 695 cases and 729 controls on TLR7 rs179008 polymorphism, totaling 652 cases and 614 controls on TLR9 rs352140 polymorphism. In meta-analysis, we employed various genetic models. The T allele of TLR7 rs179008 was conferred the risk of HIV infection (T vs A: OR = 1.25, P A = .02). An increased risk of HIV infection was found for individuals with the TLR9 rs352140 GG genotype (GG vs AA: OR = 1.50, P A = .04). Conclusions: The systematic review indicated that TLR7 rs179008 T allele provides risk effects for HIV infection. TLR9 rs352140 GG genotype may associate with HIV infection.

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Section: Resultsmentioning

confidence: 99%

Association of toll-like receptor polymorphisms with acquisition of HIV infection and clinical findings

Shi

Sun³

et al. 2020

Medicine

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“…Moreover, we have also investigated the possible correlation of the CCR5 haplotypes among Omani HIV-1-infected patients on cART with the average CD4 + T-cell count during a viremic period of 12 months before reaching the undetectable viral load level of <50 cells/μl. We have used the average CD4 + T-cell count as it provides a better understanding of the long-term effect of CCR5 haplotypes compared to the use of cross-sectional values [37,38]. In addition, we have investigated the possible correlation of those haplotypes with the rate of CD4 + T-cell recovery over the first 18 months after achieving full viral suppression following the introduction of cART.…”

Section: Polymorphisms In the Ccr5 Gene And Rate Of Aids Progressionmentioning

confidence: 99%

Genetic Diversity within Chemokine Receptor 5 (CCR5) for Better Understanding of AIDS

Al-Jabri¹,

Hasson²

2017

Genetic Diversity

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The chemokine receptor 5 (CCR5) serves as a co-receptor for the human immunodeficiency virus-1 (HIV-1) that facilitates viral entry into cells. Individuals who are homozygous for a 32 bp deletion of the CCR5 gene are resistant to infection, while for heterozygote carriers their HIV disease progression is delayed. To understand the variable HIV-1 disease course that still exists among rare carriers of this deletion, studies have focused on polymorphisms of the CCR5 gene. Nine different CCR5 human haplotypes (HH) were defined as HHA, HHB, HHC, HHD, HHE, (HHF*1 and HHF*2), and (HHG*1 and HHG*2). Less is known about the effect of these polymorphisms during combined antiretroviral treatment (cART) as the influence of the CCR5 haplotypes on the treatment outcome was not studied extensively. We have reported four novel indels and two new polymorphisms from one ethnic adult Omani population in the 5′UTR of the CCR5 gene. Genetic diversity of the CCR5 haplotypes among acquired immunodeficiency syndrome (AIDS) patients receiving cART and healthy people is discussed. Our results demonstrated the importance of genetic diversity in the CCR5 gene and clearly indicate the importance of understanding the pattern of genetic diversity and its implications for better understanding AIDS.

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“…Growing data suggest that single nucleotide polymorphisms (SNPs) of TLRs are linked to susceptibility and progression of different infectious diseases. Several polymorphisms in different TLRs have shown their effects on HIV acquisition or disease progression (19)(20)(21)(22)(23)(24). The study of a functional TLR7 variant (rs179008) in 2009 reported that TLR7 Gln11Leu was associated with susceptibility to and a more severe clinical course of HIV-1 disease (25).…”

Section: Introductionmentioning

confidence: 99%

Effects of TLR7 Polymorphisms on the Susceptibility and Progression of HIV-1 Infection in Chinese MSM Population

Zhang

Zhu

et al. 2020

Front. Immunol.

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Toll-like receptor (TLR) 7 plays a key role in innate and adaptive immunity for HIV-1 infection. We evaluated the effect of TLR7 polymorphisms on disease susceptibility and progression of HIV-1 infection in Chinese MSM (men who have sex with men). Blood samples were taken from 270 patients with laboratory confirmed HIV infection, 196 male controls were tested, and three TLR7 intronic polymorphisms (rs179010-C > T, X:12884766; rs2074109-T > C, X:12885330; and rs179009-A > G, X:12885361) were analyzed by PCR-based sequencing. The frequency of TLR7 rs179010 T allele was significantly lower in MSM patients than in controls (P = 0.039). The haplotype TTA was associated with a decreased susceptibility to HIV-1 infection (P = 0.013), especially to acute HIV-1 infection (AHI) (P = 0.002), but not to chronic HIV-1 infection (CHI). Furthermore, the haplotype TTA is linked to slow disease progression in AHI patients (P = 0.002) and a lower viral load (P = 0.042). In contrast, TLR7 rs179009 allele A contributed to a higher set point in AHI patients with rapid progression, and the frequency of rs179009 minor allele G was over-presented in CHI patients. This finding supports a role for genetic variations of TLR7 in susceptibility and disease progression of an HIV-1 infection in Chinese Han population and warrants further studies on the effect of TLR7 polymorphisms on HIV-1 infection in different populations.

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Frequency of TLR4 (1063A/G and 1363C/T) polymorphisms in healthy and HIV-infected Omani individuals and their relationship to viral load and T cell count

Cited by 5 publications

References 27 publications

Association of toll-like receptor polymorphisms with acquisition of HIV infection and clinical findings

Association of toll-like receptor polymorphisms with acquisition of HIV infection and clinical findings

Genetic Diversity within Chemokine Receptor 5 (CCR5) for Better Understanding of AIDS

Effects of TLR7 Polymorphisms on the Susceptibility and Progression of HIV-1 Infection in Chinese MSM Population

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