Frequency of the polymorphonuclear neutrophil Fc gamma receptor III deficiency in the French population and its involvement in the development of neonatal alloimmune neutropenia

Fromont, Patricia; Bettaı̈eb, Ali; Skouri, H.; Floch, Corinne; Poulet, Eliane; Duédari, Najib; Bierling, Philippe

doi:10.1182/blood.v79.8.2131.2131

Cited by 94 publications

(51 citation statements)

References 21 publications

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“…A French group found 4 (0.1%) HNA‐1 null among 3377 tested subjects, whereas a study from Spain reported 4 HNA‐1 null individuals among 500 tested. In Brazil, our group found 11 of 92 Amazon native Indians who could represent deletions of NA 1 and NA 2 genes (13, 15, 16). In the present study, we did not identify NA‐null phenotype in Brazilian individuals probably because of the relative small number of tested subjects ( n = 100).…”

Section: Discussioncontrasting

confidence: 73%

Human neutrophil alloantigen‐1a, ‐1b, ‐2, ‐3a and ‐4a frequencies in Brazilians

Norcia¹,

Sugano²,

Chiba³

et al. 2009

Tissue Antigens

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Human neutrophil reactive antibodies may cause clinical disorders such as transfusion-related acute lung injury, febrile transfusion reactions, alloimmune neonatal neutropenia, immune neutropenia after stem cell transplantation, refractoriness to granulocyte transfusion, drug-induced neutropenia and autoimmune neutropenia. Using the granulocyte immunofluorescence test by flow cytometry, the phenotypic frequencies of the human neutrophil alloantigens (HNA)-1a, -1b, -2, -3a and -4a were determined in 100 healthy Brazilian persons. Neutrophils were separated from blood samples by sedimentation, centrifugated and incubated with HNA-specific alloantibody plus fluorescein isothiocyanate-labeled F(ab')(2) fragments of anti-human IgG. The results showed that the phenotype frequencies of HNA-1a, -1b, -2a, -3a and -4a were 65%, 83%, 97%, 95% and 94%, respectively. We detected that neutrophils from 17% of Brazilians typed positive only with anti-HNA-1a (HNA-1a/a), 35% only with anti-HNA-1b (HNA-1b/b) and 48% reacted with both antibodies (HNA-1a/b). The frequencies found for HNA-1a and -1b were quite similar to that reported among Africans and American-Africans, but different from those found in Japanese and Chinese. In addition, our data showed that the frequencies of HNA-2, -3a and -4a in Brazilians were comparable with those observed in Caucasians. The determination of HNAs frequencies among populations with distinct racial backgrounds is important not only for anthropological reasons, but also for neonatal typing in suspected cases of alloimmune neutropenia or when patients are severely neutropenic.

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Section: Discussioncontrasting

confidence: 73%

Human neutrophil alloantigen‐1a, ‐1b, ‐2, ‐3a and ‐4a frequencies in Brazilians

Norcia¹,

Sugano²,

Chiba³

et al. 2009

Tissue Antigens

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“…In addition, we found 11 Amerindians (12.0%) whose DNA samples were not amplified for NA1 or NA2 alleles. Several persons have been described in the literature whose neutrophils lack the low‐affinity FcγRIIIB and who were therefore classified as “NA null.” A French group found 4 “NA null” cases among 3377 tested, 11 a study from Spain reported 4 “NA null” individuals among 500 tested, 12 and a German investigation found 1 “NA null” subject among more than 1000 tested blood donors 13 . On the other hand, variations in NA1 and NA2 alleles have recently been described, but, when analyzed by flow cytometry with specific antibodies, the neutrophils from subjects with such genetic variations do not show phenotypic changes 14 .…”

Section: Discussionmentioning

confidence: 97%

Allelic polymorphisms of human Fcγ receptor IIa and Fcγ receptor IIIb among distinct groups in Brazil

Kuwano

Bordin²,

Chiba³

et al. 2000

Transfusion

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Overall, the data indicate that the distribution of the FcgammaRIIIB alleles is significantly different in Amazon Indians from the distribution in Brazilian blood donors or African Brazilian patients with SCD, but that it is similar to the distributions reported in Asian populations. Moreover, the distribution of the FcgammaRIIA and FcgammaRIIIB alleles among Brazilian blood donors and SCD patients is comparable to the distributions reported in whites from the United States and Europe.

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“…The third allele product, SH (HNA‐1c), differs from NA2 by a single amino acid substitution, and is present in a small proportion of Caucasians as well as in a larger proportion of the African population (11). Furthermore, approximately 0.1% of the European population was shown to be deficient in the FCGR3B gene (16).…”

mentioning

confidence: 99%

Association of Fcγ receptor IIb and IIIb polymorphisms with susceptibility to systemic lupus erythematosus in Thais

et al. 2003

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We recently reported association of a newly identified polymorphism of Fcgamma receptor (FcgammaR) IIb, I232T, with systemic lupus erythematosus (SLE) in Japanese. To date, information on FcgammaR genotypes and their association with SLE is limited in South-east Asian populations. To gain further insight into the role of FcgammaR polymorphisms in the genetic predisposition of SLE, association of FcgammaRIIa-H131R, IIb-I232T, IIIa-F176V and IIIb-NA1/NA2 (HNA-1a/1b) polymorphisms with SLE was analyzed in the Thai population, using case-control association analysis. FcgammaRIIb-232T/T and IIIb-NA2/NA2 genotypes were associated with SLE with the odds ratio of 2.55. Genotype relative risk analysis revealed significant association of IIb-232T/T and IIIb-NA2/NA2, and a tendency of association of the IIIa-176F/F genotype. Moreover, carriers of FcgammaRIIa-131R were significantly increased in patients with lupus nephritis. Significant linkage disequilibrium was present among FcgammaRIIb, IIIa and IIIb, and two-locus analyses suggested that the tendency of association of FcgammaRIIIa could derive from linkage disequilibrium with IIb and IIIb. These results provided evidence that FcgammaR polymorphisms may be an important predisposing factor also in Thais in a complex manner.

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Frequency of the polymorphonuclear neutrophil Fc gamma receptor III deficiency in the French population and its involvement in the development of neonatal alloimmune neutropenia

Cited by 94 publications

References 21 publications

Human neutrophil alloantigen‐1a, ‐1b, ‐2, ‐3a and ‐4a frequencies in Brazilians

Human neutrophil alloantigen‐1a, ‐1b, ‐2, ‐3a and ‐4a frequencies in Brazilians

Allelic polymorphisms of human Fcγ receptor IIa and Fcγ receptor IIIb among distinct groups in Brazil

Association of Fcγ receptor IIb and IIIb polymorphisms with susceptibility to systemic lupus erythematosus in Thais

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