Frequency of the 735G → A mutation of the 5′-splice donor site of intron 14 of the dihydropyrimidine dehydrogenase gene (DPYD) in residents of novosibirsk region (Russia) as revealed with fluorescent oligonucleotides

This article is dedicated to rationale of pharmacotherap y in the treatment of depressive disorders. Differentiation of allele gene variances, linked to metabolism of antidepressants, was conducted. Genetic status of patients and individual parameters of antidepressant’s metabolism took into account in every clinical case. Results of this research can allowed to forecast effectivene ss, compliance and tolerance of antidepressants.

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Psychopharmacogenetic approach in therapy of affective disorders depressive spectrum

Штарк¹,

Загоруйко²,

Kovalenko³

et al. 2009

Bûll. sib. med.

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Analysis of carrying clinically significant allelic variants of TPMT and DPYD genes associated with the response to drug therapy in cancer practice among 9 ethnic groups of the Russian Federation

Мирзаев

Бадавиевичр²,

Fedorinov

et al. 2020

Terapevticheskii arkhiv

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Aim. To study the peculiarities of carrying clinically significant allelic variants of TPMT and DPYD genes associated with the response to drug therapy in cancer practice among 9 ethnic groups of the Russian Federation. Materials and methods. The study included 1446 conditionally healthy volunteers from 9 ethnic groups. Carriage of polymorphic TPMT and DPYD gene markers was detected by the Real-Time PCR (polymerase chain reaction) method. Results. In all ethnic groups, the distribution of genotypes and alleles matched the equilibrium of Hardy-Weinberg. TPMT*3A (rs1800460) and TPMT*3C (rs1142345) were observed in heterozygous state in all investigated ethnic groups. In the Kabardinian group (n=204) the frequency of the TPMT*3A minor allele (MAF, %) was 2.94%; Balkars (n=200) 1.25%; Ossetians (n=239) 1.67%; Chuvashes (n=238) 1.89%: Mari (n=206) 1.21%; Tatars (n=141) 1.77%; Russians (n=134) 4.85%. The frequency of the TPMT*3C minor allele (MAF, %) in the Kabardinian group (n=204) MAF was 4.90%; Balkars (n=200) 1. 75%; Buryats (n=114) 0.44%; Ossetians (n=239) 1.88%; Chuvashes (n=238) 1.68%: Mari (n=206) 1.21%; Tatars (n=141) 1.42%; Russians (n=134) 4.48%. The results of the analysis of DPYD*2A polymorphism (rs3918290) demonstrated ethnic peculiarities of distribution. In the heterozygous state it was found only in the groups of Kabardins (n=204, MAF 1.22%), Balkars (n=200, MAF 2.00%), and Ossetians (n=239, MAF 0.63%). Conclusion. The results obtained in the study will be useful for developing personalized algorithms of antitumor therapy in cancer practice, including those aimed at increasing the safety of chemotherapy.

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Frequency of the 735G → A mutation of the 5′-splice donor site of intron 14 of the dihydropyrimidine dehydrogenase gene (DPYD) in residents of novosibirsk region (Russia) as revealed with fluorescent oligonucleotides

Cited by 2 publications

References 15 publications

Psychopharmacogenetic approach in therapy of affective disorders depressive spectrum

Psychopharmacogenetic approach in therapy of affective disorders depressive spectrum

Analysis of carrying clinically significant allelic variants of TPMT and DPYD genes associated with the response to drug therapy in cancer practice among 9 ethnic groups of the Russian Federation

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