Frequency of Stages of Alzheimer-Related Lesions in Different Age Categories

Left hippocampal volume loss in Alzheimer's disease is reflected in performance on odor identification: A structural MRI study

“…Although the entorhinal cortex is clearly multimodal, its integrity will be critical for processing olfactory information that relies on memory because it represents the direct and substantial link between incoming olfactory input and the hippocampus. Thus degeneration of the entorhinal cortex and the resulting disconnection from the hippocampus (Braak & Braak, 1997) might be expected to affect activation in hippocampus during odor tasks with memory components.…”

Tau pathology in children and young adults: can you still be unconditionally baptist?

“…It should be stressed, however, that neuropathological data do not fit this hypothetical representation. Braak et al [2] have shown, as early as 1997, that tau pathology in the entorhinal-hippocampal region precedes Ab accumulation by decades. The comparison of the curves drawn from Braak et al data (Fig.…”

Amyloid-β imaging with PET in Alzheimer’s disease: is it feasible with current radiotracers and technologies?

“…1). A similar pathological study of 2,661 autopsy cases found that amyloid plaques are concentrated in the temporal gray matter and the perirhinal and ectorhinal fields in early AD, and do not spread to the frontal lobe until later stages of the disease [16]. A study of cerebral degeneration, which is considered by the amyloid hypothesis to be a direct consequence of Aβ deposition, pinpointed the medial temporal cortex as the epicenter of neuronal deterioration, with damage radiating first and foremost to the parietal and occipital areas.…”