Frequency of specific anti-Toxoplasma gondii IgM, IgA and IgE in Colombian patients with acute and chronic ocular toxoplasmosis

Gómez‐Marín, Jorge Enrique; Montoya-de-Londono, Maria Teresa; Castaño-Osorio, Jhon Carlos; Heine, Fernando Alvarado; Duque, Ana Maria; Chemla, Cathy; Aubert, Dominique; Bonhomme, A.; Pinon, J. M.

doi:10.1590/s0074-02762000000100014

Cited by 19 publications

(9 citation statements)

References 14 publications

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“…Many characteristics of the lesions are similar to those previously reported 10,11,13 with a predominance of macular localization. Papillitis has been described as an atypical presentation in ocular toxoplasmosis; we found this in 7% of cases, which is near to the 5% reported in Turkey.…”

Section: Discussionsupporting

confidence: 86%

“…10,11 The frequency of 17% of a positive IgM assay was lower than that reported previously of 47% for patients during the acute phase of ocular toxoplasmosis in the same region in Colombia by the high-sensitive assay ISAGA and of 37% in Iran. 12,13 This could be partly explained by the different commercial assays used. Our series includes a high number of congenital cases and we confirm that in these cases bilateral involvement was more frequent as reported by other authors.…”

Section: Discussionmentioning

confidence: 99%

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Incidence and clinical characteristics in a Colombian cohort of ocular toxoplasmosis

de-la-Torre

López-Castillo

Gómez‐Marín

2008

Eye

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Incidence and clinical characteristics in a Colombian cohort of ocular toxoplasmosis

de-la-Torre

López-Castillo

Gómez‐Marín

2008

Eye

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“…Particularly IL-6 is a major proinflammatory cytokine in uveitis and elevated intraocular levels were found in AH of patients with uveitis of diverse origins, including ocular toxoplasmosis, viral uveitis, Fuchs heterochromic uveitis syndrome [32–38]. IL-6 can enhance the progression of the parasite by activation of STAT-3, which is an inhibitor of the protective cytokine IL-12 [39].…”

Section: Discussionmentioning

confidence: 99%

“…This cytokine has an important role in the induction of a Th2 response and antibody production by enhancing specific IgA production [31], which has been described as predictor of recurrences in ocular toxoplasmosis [32]. This makes IL-5 a good candidate for a prognostic marker.…”

Section: Discussionmentioning

confidence: 99%

Ocular cytokinome is linked to clinical characteristics in ocular toxoplasmosis

et al. 2014

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Purpose To determine the cytokine levels in aqueous humor (AH) of Colombian patients with active ocular toxoplasmosis (OT), and to correlate them with their clinical characteristics. Methods 27 Cytokines/chemokines were assayed in 15 AH samples (nine patients with diagnosis of OT biologically-confirmed and six controls that underwent cataract surgery). Correlations were assessed between cytokine/chemokine levels, type of inflammatory response (Th1, Th2, Th17, Treg), and clinical characteristics. Results Th2 predominant response was related to more severe clinical features. The presence of VEGF and IL-5 was related to higher number of recurrences. Growth factors (VEGF, FGF, PDGF-β), were related to higher number of lesions. Patients infected by type-I/III strains had a particular intraocular cytokine-pattern. Conclusions Th2 response was related to more severe clinical characteristics in patients infected by Type I/III strains. IL-5 and VEGF were associated with recurrences. We correlate for the first time, specific cytokine-patterns with clinical characteristics and with the infecting Toxoplasma strain.

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“…Tissue damage can begin during pregnancy and sometimes continues after birth, during infancy, or later in adulthood, causing neuropsychomotor and optical sequelae. 7,11,15 Because of the persistence of certain classes of antibodies, such as IgM and IgA, and the high sensitivity of the serological methods currently available, complementary tests are necessary in order to assess more accurately the chronology of the infection in pregnant women. 8 However, the risk of congenital transmission may exist not only in cases of seroconversion, but also in cases of suspected infection as detected by elevated mean titers of IgM and/or IgA and IgG.…”

Section: Introductionmentioning

confidence: 99%

Suspected acute toxoplasmosis in pregnant women

2007

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OBJECTIVE:To determine the prevalence of reagent serology for suspected acute toxoplasmosis in pregnant women and to describe clinical, laboratory and therapeutic profiles of mothers and their children. METHODS:A retrospective study was conducted with IgM-anti-Toxoplasma gondiireagent pregnant women and their children who attended the public health system in the state of Paraná, Southern Brazil, from January 2001 to December 2003. Information were obtained from clinical, laboratory (ELISA IgM/IgG) and ultrasonographic data and from interviews with the mothers. To test the homogeneity of the IgM indices in relation to the treatment used, the Pearson's Chi-square test was applied. Comparisons were considered significant at a 5% level. RESULTS:Two hundred and ninety (1.0%) cases of suspected IgM-reagent infection were documented, with a prevalence of 10.7 IgM-reagent women per 1,000 births. Prenatal care started within the first 12 weeks for 214/290; 146/204 were asymptomatic. Frequent complaints included headaches, visual disturbance and myalgia. Ultrasonography revealed abnormalities in 13 of 204 pregnancies. Chemoprophylaxis was administered to 112/227; a single ELISA test supported most decisions to begin treatment. Pregnant women with IgM indices =2.000 tended to be treated more often. Among exposed children, 44/208 were serologically followed up and all were IgGreagent, and three IgM-reagent cases showed clinical symptoms. CONCLUSIONS:The existence of pregnant women with laboratorially suspected acute toxoplasmosis who were not properly followed up, and of fetuses that were not adequately monitored, shows that basic aspects of the prenatal care are not being systematically observed. There is need of implementing a surveillance system of pregnant women and their children exposed to T. gondii. CONCLUSÕES: A existência de gestantes com suspeita laboratorial de toxoplasmose aguda não devidamente investigada e de conceptos sem monitoração adequada evidenciam que aspectos fundamentais da assistência pré-natal não estão sendo sistematicamente observados. Aponta-se a necessidade de implementar o sistema de vigilância para gestantes e crianças expostas ao T. gondii.28 Rev Saúde Pública 2007;41(1):27-34 Suspected acute toxoplasmosis in pregnancy Castilho-Pelloso MP et al Para testar a homogeneidade dos indices de IgM em relação ao tratamento usado, aplicou

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Frequency of specific anti-Toxoplasma gondii IgM, IgA and IgE in Colombian patients with acute and chronic ocular toxoplasmosis

Abstract: We studied the frequency of specific anti-Toxoplasma IgM, IgA

Cited by 19 publications

References 14 publications

Incidence and clinical characteristics in a Colombian cohort of ocular toxoplasmosis

Incidence and clinical characteristics in a Colombian cohort of ocular toxoplasmosis

Ocular cytokinome is linked to clinical characteristics in ocular toxoplasmosis

Suspected acute toxoplasmosis in pregnant women

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