Frequency of SARS-CoV-2 infection in dogs and cats: Results of a retrospective serological survey in Šumadija District, Serbia

Stanojevic, Slavoljub; Radojicic, Sonja; Misic, Dusan; Srejić, Damjan; Vasiljevic, Dragan V.; Prokic, Kristina; Ilić, Nevenka

doi:10.1016/j.prevetmed.2022.105755

Cited by 5 publications

(6 citation statements)

References 28 publications

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“…Only one of the seropositive animals exhibited SARS-CoV-2 symptoms as diarrhea at the sampling date (Table 1, Supplementary Table S1). Frequent contact with COVID-19 patients or asymptomatic infected people is the leading cause of SARS-CoV-2 transmission from humans to animals (38)(39)(40)(41). Until the beginning of April, 2022, the infection rate of COVID-19 was estimated at 0.65% (941,545/1,443,497,378) among humans in China.…”

Section: Resultsmentioning

confidence: 99%

Serological survey of SARS-CoV-2 in companion animals in China

et al. 2022

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Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) can be transmitted from human to companion animals. The national wide serological surveillance against SARS-CoV-2 was conducted among pet animals, mainly in cats and dogs, 1 year after the first outbreak of COVID-19 in China. All sera were tested for SARS-CoV-2 IgG antibodies using an indirect enzyme linked immunosorbent assay (ELISA) based on the receptor binding domain (RBD) of spike protein. This late survey takes advantage of the short duration of the serological response in these animals to track recent episode of transmission. A total of 20,592 blood samples were obtained from 25 provinces across 7 geographical regions. The overall seroprevalence of SARS-CoV-2 infections in cats was 0.015% (2/13397; 95% confidence intervals (CI): 0.0, 0.1). The virus infections in cats were only detected in Central (Hubei, 0.375%) and Eastern China (Zhejiang, 0.087%) with a seroprevalence estimated at 0.090 and 0.020%, respectively. In dogs, the seroprevalence of SARS-CoV-2 infections was 0.014% (1/7159; 95% CI: 0.0, 0.1) in the entire nation, seropositive samples were limited to Beijing (0.070%) of Northern China with a prevalence of 0.054%. No seropositive cases were discovered in other geographic regions, nor in other companion animals analyzed in this study. These data reveal the circulation of SARS-CoV-2 in companion animals, although transmission of the virus to domestic cats and dogs is low in China, continuous monitoring is helpful for the better understand of the virus transmission status and the effect on animals.

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Section: Resultsmentioning

confidence: 99%

Serological survey of SARS-CoV-2 in companion animals in China

et al. 2022

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“… Forest Plot of the Meta-analysis regarding the difference in risk of SARS-CoV-2 infection in dogs and cats in America and Europe [ 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 ]. …”

Section: Figurementioning

confidence: 99%

Assessment of the Risk Impact of SARS-CoV-2 Infection Prevalence between Cats and Dogs in America and Europe: A Systematic Review and Meta-Analysis

Silva,

Santana,

Lima

et al. 2024

Pathogens

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The COVID-19 pandemic represented a huge obstacle for public health and demonstrated weaknesses in surveillance and health promotion systems around the world. Its etiological agent, SARS-CoV-2, of zoonotic origin, has been the target of several studies related to the control and prevention of outbreaks and epidemics of COVID-19 not only for humans but also for animals. Domestic animals, such as dogs and cats, have extensive contact with humans and can acquire the infection both naturally and directly from humans. The objective of this article was to summarize the seroprevalence findings of SARS-CoV-2 in dogs and cats and correlate them with the strength of infection risk between each of them. This is a systematic review and meta-analysis following the recommendations of PRISMA 2020. The search and selection of papers was carried out using in vivo experimental works with animals using the descriptors (MeSH/DeCS) “Animal”, “Public Health”, “SARS-CoV-2” and “Pandemic” (together with AND) in English, Portuguese or Spanish for Science Direct, PUBMED, LILACS and SciELO databases. The ARRIVE checklist was used for methodological evaluation and the Comprehensive Meta-Analysis v2.2 software with the Difference Risk (RD) test to evaluate statistical inferences (with subgroups by continent). Cats showed greater susceptibility to SARS-CoV-2 compared to dogs both in a joint analysis of studies (RD = 0.017; 95% CI = 0.008–0.025; p < 0.0001) and in the American subgroup (RD = 0.053; 95% CI = 0.032–0.073; p < 0.0001), unlike the lack of significant difference on the European continent (RD = 0.009; 95% CI = −0.001–0.018; p = 0.066). Therefore, it was observed that cats have a greater interest in health surveillance due to the set of biological and ecological aspects of these animals, but also that there are a set of factors that can influence the spread and possible spillover events of the virus thanks to the anthropozoonotic context.

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“…The presence of antibodies against the SARS-CoV-2 antigen was tested using a double antigen ELISA (ID-Screen ® ELISA, SARS-CoV-2 double antigen multi-species, ID.vet, Grabels, France), following the manufacturer's instructions, and as previously described [35] and used in other studies [25,26,36]. This kit detects specific anti-SARS-CoV-2 nucleocapsid (N-Protein) antibodies.…”

Section: Sars-cov-2 Serological Testingmentioning

confidence: 99%

“…A number of studies have shown that cats can be infected and develop antibodies to SARS-CoV-2 [22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39]. The statistically significant risk factors for infection or seropositivity mainly relate to living in a home with a person infected by SARS-CoV-2 [24,30,31,[36][37][38][39] and, in particular, cats that are in close contact with infected owners are at a higher risk of becoming infected than other, unexposed animals [28,36]. Sharing a bed with the infected owner or being kissed by owners were significant associated risk factors for pet infection [30,38].…”

Section: Introductionmentioning

confidence: 99%

“…In fact, compared with cats originating from households, cats that were in a shelter, rescue, or foster facility were 3.6 times more likely to be seropositive [40]. Studies had assessed but not found significant associations between SARS-CoV-2 status in cats and age, sex [25,29,30,34,36,38,41], breed [25], contact with the outdoors [41], number of cats in the household [24,30,31], and coinfections [29,38].…”

Section: Introductionmentioning

confidence: 99%

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Do Blood Phenotypes of Feline AB Blood Group System Affect the SARS-CoV-2 Antibody Serostatus in Cats?

Spada

Bruno

Castelli

et al. 2022

Viruses

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Cats are susceptible to coronavirus infections, including infection by human severe acute respiratory syndrome coronavirus (SARS-CoV). In human ABO system blood groups, alloantibodies can play a direct role in resistance to infectious diseases. Individuals with the AB blood type were over-represented in the SARS-CoV-2 infection group. Blood type AB individuals lack both anti-A and anti-B antibodies, and therefore lack the protective effect against SARS-CoV-2 infection given by these antibodies. Starting from this knowledge, this pilot preliminary study evaluated a possible association between feline blood phenotypes A, B, and AB and serostatus for SARS-CoV-2 antibodies in cats. We also investigated selected risk or protective factors associated with seropositivity for this coronavirus. A feline population of 215 cats was analysed for AB group system blood phenotypes and antibodies against the nucleocapsid (N-protein) SARS-CoV-2 antigen using a double antigen ELISA. SARS-CoV-2 seropositive samples were confirmed using a surrogate virus neutralization test (sVNT). Origin (stray colony/shelter/owned cat), breed (DSH/non DSH), gender (male/female), reproductive status (neutered/intact), age class (kitten/young adult/mature adult/senior), retroviruses status (seropositive/seronegative), and blood phenotype (A, B, and AB) were evaluated as protective or risk factors for SARS-CoV-2 seropositivity. Seropositivity for antibodies against the SARS-CoV-2 N-protein was recorded in eight cats, but only four of these tested positive with sVNT. Of these four SARS-CoV-2 seropositive cats, three were blood phenotype A and one was phenotype AB. Young adult age (1–6 years), FeLV seropositivity and blood type AB were significantly associated with SARS-CoV-2 seropositivity according to a univariate analysis, but only blood type AB (p = 0.0344, OR = 15.4, 95%CI: 1.22–194.39) and FeLV seropositivity (p = 0.0444, OR = 13.2, 95%CI: 1.06–163.63) were significant associated risk factors according to a logistic regression. Blood phenotype AB might be associated with seropositivity for SARS-CoV-2 antibodies. This could be due, as in people, to the protective effect of naturally occurring alloantibodies to blood type antigens which are lacking in type AB cats. The results of this pilot study should be considered very preliminary, and we suggest the need for further research to assess this potential relationship.

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Frequency of SARS-CoV-2 infection in dogs and cats: Results of a retrospective serological survey in Šumadija District, Serbia

Cited by 5 publications

References 28 publications

Serological survey of SARS-CoV-2 in companion animals in China

Serological survey of SARS-CoV-2 in companion animals in China

Assessment of the Risk Impact of SARS-CoV-2 Infection Prevalence between Cats and Dogs in America and Europe: A Systematic Review and Meta-Analysis

Do Blood Phenotypes of Feline AB Blood Group System Affect the SARS-CoV-2 Antibody Serostatus in Cats?

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