Frequency of sarcopenia, cachexia, and associated factors in patients with chronic kidney disease in dialysis treatment

Oliveira, Edilene Maria de; Silva, Renata Pereira da; Lemos, Manoel; Burgos, Maria Goretti Pessôa de Araújo; Costa, Denise Maria Nascimento; Maio, Regiane

doi:10.20960/nh.02954

Cited by 2 publications

(4 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The studies were published between 2014 and 2022 and varied in sample size (33 to 645 patients). Among the included studies, twenty-one studies were conducted in Asian countries (China, Iran, Japan, Korea, Taiwan, Thailand, and Turkey) [ 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 ], nine in European countries (France, Sweden, Spain, and United Kingdom) [ 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 ], eight in South American countries (Brazil and Argentina) [ 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 ], two in the USA [ 57 , 58 ], and the remaining one in Australia [ 59 ]. These studies yielded a total sample of five continents (Asia: 45.6%, Europe: 25.9%, North America: 14.3%, South America: 13.7%, and Australia: 0.5%).…”

Section: Resultsmentioning

confidence: 99%

“… Forest plot visualizing the varying sarcopenic prevalence in dialysis patients reported as event rate for each study included publication in the meta-analysis [ 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 ]. …”

Section: Figurementioning

confidence: 99%

See 1 more Smart Citation

Prevalence of Sarcopenia and Its Impact on Cardiovascular Events and Mortality among Dialysis Patients: A Systematic Review and Meta-Analysis

et al. 2022

View full text Add to dashboard Cite

Sarcopenia in end-stage kidney disease patients requiring dialysis is a frequent complication but remains an under-recognized problem. This meta-analysis was conducted to determine the prevalence of sarcopenia and explored its impacts on clinical outcomes, especially cardiovascular events, and mortality in dialysis patients. The eligible studies were searched from PubMed, Scopus, and Cochrane Central Register of Controlled trials up to 31 March 2022. We included studies that reported the interested outcomes, and the random-effects model was used for analysis. Forty-one studies with 7576 patients were included. The pooled prevalence of sarcopenia in dialysis patients was 25.6% (95% CI 22.1 to 29.4%). Sarcopenia was significantly associated with higher mortality risk (adjusted OR 1.83 (95% CI 1.40 to 2.39)) and cardiovascular events (adjusted OR 3.80 (95% CI 1.79 to 8.09)). Additionally, both low muscle mass and low muscle strength were independently related to increased mortality risk in dialysis patients (OR 1.71; 95% CI (1.20 to 2.44), OR 2.15 (95% CI 1.51 to 3.07)), respectively. This meta-analysis revealed that sarcopenia was highly prevalent among dialysis patients and shown to be an important predictor of cardiovascular events and mortality. Future intervention research to alleviate this disease burden in dialysis patients is needed.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Prevalence of Sarcopenia and Its Impact on Cardiovascular Events and Mortality among Dialysis Patients: A Systematic Review and Meta-Analysis

et al. 2022

View full text Add to dashboard Cite

show abstract

“…In Caucasian populations, the BMI cutoff point for obesity is 30 kg/m 2 [40]. A weight loss of at least 5% in 12 months or less or a BMI < 20 kg/m 2 is diagnostic of cachexia [41].…”

Section: Study Variablesmentioning

confidence: 99%

“…(C) Analytical variables: The following parameters were measured: serum albumin, proteins, hemoglobin, hematocrit, cholesterol, lymphocytes, protein catabolism rate and 25OH vitamin D [41,45,46]. In addition, dialytic efficacy was assessed using Daurgidas' Kt/Vurea [47].…”

Section: Study Variablesmentioning

confidence: 99%

A Sarcopenia Index Derived from Malnutrition Parameters in Elderly Haemodialysis Patients

et al. 2023

View full text Add to dashboard Cite

(1) Background: Persons with chronic kidney disease may have sarcopenia characterized by the loss of muscle mass and loss of muscle strength. However, EWGSOP2 criteria to diagnose sarcopenia are technically challenging, especially in elderly persons on hemodialysis. Sarcopenia may be associated with malnutrition. We aimed at defining a sarcopenia index derived from malnutrition parameters for use in elderly haemodialysis patients. (2) Methods: A retrospective study of 60 patients aged 75 to 95 years treated with chronic hemodialysis was conducted. Anthropometric and analytical variables, EWGSOP2 sarcopenia criteria and other nutrition-related variables were collected. Binomial logistic regressions were used to define the combination of anthropometric and nutritional parameters that best predict moderate or severe sarcopenia according to EWGSOP2, and performance for moderate and severe sarcopenia was assessed by the area under the curve (AUC) of receiver operating characteristic (ROC) curves. (3) Results: The combination of loss of strength, loss of muscle mass and low physical performance correlated with malnutrition. We developed regression-equation-related nutrition criteria that predicted moderate sarcopenia (elderly hemodialysis sarcopenia index-moderate, EHSI-M) and severe sarcopenia (EHSI-S) diagnosed according to EWGSOP2 with an AUC of 0.80 and 0.866, respectively. (4) Conclusions: There is a close relationship between nutrition and sarcopenia. The EHSI may identify EWGSOP2-diagnosed sarcopenia from easily accessible anthropometric and nutritional parameters.

show abstract

Frequency of sarcopenia, cachexia, and associated factors in patients with chronic kidney disease in dialysis treatment

Abstract: supplementation promotes improvement of chronic diarrhea of unknown etiology in patient with chronic kidney disease and provides better outcomes in dialysis.

Cited by 2 publications

References 20 publications

Prevalence of Sarcopenia and Its Impact on Cardiovascular Events and Mortality among Dialysis Patients: A Systematic Review and Meta-Analysis

Prevalence of Sarcopenia and Its Impact on Cardiovascular Events and Mortality among Dialysis Patients: A Systematic Review and Meta-Analysis

A Sarcopenia Index Derived from Malnutrition Parameters in Elderly Haemodialysis Patients

Contact Info

Product

Resources

About