Frequency of rs2282649 and rs12285364 polymorphisms in SORL1 gene and their association with Alzheimer’s disease in Azari population in northwest of Iran
Abstract:Background and Aim: Alzheimer's disease is the most common cause of dementia in old people. AD is a progressive and irreversible neurodegenerative brain disorder. Sortilin receptor 1 (SORL1) is involved in cellular trafficking of amyloid precursor protein and plays an essential role in amyloid-beta peptide generation in the AD. The purpose of the present study was to evaluate the association of SORL1 rs2282649 and rs12285364 polymorphism with AD in Azeri population in the northwest of Iran. Materials and Metho… Show more
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