Frequency of regulatory B cells in adipose tissue and peripheral blood from individuals with overweight, obesity and normal-weight

García-Hernández, Mariana Haydee; Rodríguez-Varela, Eduardo; García-Jacobo, R.E.; Torre, M. Hernández-De la; Uresti-Rivera, Edith Elena; González‐Amaro, Roberto; Portales-Pérez, Diana Patricia

doi:10.1016/j.orcp.2018.07.001

Cited by 30 publications

(27 citation statements)

References 32 publications

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“…Indeed, obesity can induce B cell defects with decreased frequency of regulatory B cell in association with higher frequencies of circulating Th1/Th17 cell [ 19 ]. In obese mice and humans, it has been demonstrated that adipose tissue (AT) B cells present antigen, secrete pro-inflammatory cytokines and chemokines, as well as autoimmune pathogenic antibodies [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Early Onset of SARS-COV-2 Antibodies after First Dose of BNT162b2: Correlation with Age, Gender and BMI

et al. 2021

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Background: The first goal of the study was to analyse the antibody titre 21 days after the first dose of the BNT162b2 vaccine in a group of 252 healthcare workers (HCW). The second goal was to analyse how the antibody titre changes in correlation with age, gender and body mass index (BMI). Methods: Participants had a nasopharyngeal swab for SARS-CoV-2 and were assessed for the presence of SARS-CoV-2 antibodies at baseline and 21 days after the BNT162b2 priming dose. Results: First dose of BNT162b2 activated immune responses in 98% of the participants. Five HWC had no increase in antibody titre 21 days after the first dose. Antibody titre was greater in young (<38 years) vs. older participants (<38 vs. 47–56 p = 0.002; <38 vs. >56 p = 0.001). Higher antibody levels were detected in underweight vs. pre-obesity group (p = 0.026) and in normal-weight vs. pre-obesity group (p = 0.007). This association was confirmed after adjusting for age (p = 0.0001) and gender (p = 0.00001). Conclusions: Our study demonstrates that a single dose of BNT162b2 activates the immune response, and being young and normal-weight correlate positively with this response. Larger specifically designed clinical trials are needed to validate these results.

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Section: Discussionmentioning

confidence: 99%

Early Onset of SARS-COV-2 Antibodies after First Dose of BNT162b2: Correlation with Age, Gender and BMI

et al. 2021

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“…Contrary to B-2 cells, B-1 cell-derived natural IgG and anti-inflammatory cytokines block AT inflammation and improve glucose tolerance through inducing M2 macrophage polarization and increasing their production of IL-10, while reducing their production of IL-6 and TNF-α (321,322,(332)(333)(334)(335). The number of Breg cells, which are present in AT, is reduced in diabetic patients in comparison to healthy donors (336,337). Moreover, Breg cells from diabetic patients secrete less IL-10 (329, 330).…”

Section: B Cellsmentioning

confidence: 99%

Adipose Tissue Immunomodulation: A Novel Therapeutic Approach in Cardiovascular and Metabolic Diseases

AlZaim

Hammoud

Al-Koussa

et al. 2020

Front. Cardiovasc. Med.

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Adipose tissue is a critical regulator of systemic metabolism and bodily homeostasis as it secretes a myriad of adipokines, including inflammatory and anti-inflammatory cytokines. As the main storage pool of lipids, subcutaneous and visceral adipose tissues undergo marked hypertrophy and hyperplasia in response to nutritional excess leading to hypoxia, adipokine dysregulation, and subsequent low-grade inflammation that is characterized by increased infiltration and activation of innate and adaptive immune cells. The specific localization, physiology, susceptibility to inflammation and the heterogeneity of the inflammatory cell population of each adipose depot are unique and thus dictate the possible complications of adipose tissue chronic inflammation. Several lines of evidence link visceral and particularly perivascular, pericardial, and perirenal adipose tissue inflammation to the development of metabolic syndrome, insulin resistance, type 2 diabetes and cardiovascular diseases. In addition to the implication of the immune system in the regulation of adipose tissue function, adipose tissue immune components are pivotal in detrimental or otherwise favorable adipose tissue remodeling and thermogenesis. Adipose tissue resident and infiltrating immune cells undergo metabolic and morphological adaptation based on the systemic energy status and thus a better comprehension of the metabolic regulation of immune cells in adipose tissues is pivotal to address complications of chronic adipose tissue inflammation. In this review, we discuss the role of adipose innate and adaptive immune cells across various physiological and pathophysiological states that pertain to the development or progression of cardiovascular diseases associated with metabolic disorders. Understanding such mechanisms allows for the exploitation of the adipose tissue-immune system crosstalk, exploring how the adipose immune system might be targeted as a strategy to treat cardiovascular derangements associated with metabolic dysfunctions.

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“…In support, B cell‐specific IL‐10 deletion increases the numbers of CD8 + T cells and M1‐like macrophages within the AT of HFD‐fed and lean mice . García‐Hernández et al indicated that the frequencies of IL‐10‐producing CD19 + CD27 + CD38 High and CD19 + CD24 High CD38 High Bregs are decreased in the peripheral blood and AT of overweight and obese individuals compared with normal weight …”

Section: Adaptive Immune Responsesmentioning

confidence: 99%

An update on immune dysregulation in obesity‐related insulin resistance

2019

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Obesity is associated with chronic low‐grade inflammation of the adipose tissue (AT) that might develop into systemic inflammation, insulin resistance (IR) and an increased risk of type 2 diabetes mellitus (T2DM) in severe obese rodents and humans. In the lean state, small normal adipocytes and AT macrophages interact with each other to maintain metabolic homeostasis but during obesity, enlarged adipocytes secrete inflammatory mediators and express immune receptors to recruit immune cells and aggravate the inflammation. The better understanding of the obesity‐related inflammatory milieu and the sequential events leading to IR could be helpful in designing new preventive and therapeutic strategies. The present review will discuss the cellular and molecular abnormalities participating in the pathogenesis of obesity in obese individuals as well as high‐fat diet (HFD)‐fed mice, a mouse model of obesity.

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Frequency of regulatory B cells in adipose tissue and peripheral blood from individuals with overweight, obesity and normal-weight

Cited by 30 publications

References 32 publications

Early Onset of SARS-COV-2 Antibodies after First Dose of BNT162b2: Correlation with Age, Gender and BMI

Early Onset of SARS-COV-2 Antibodies after First Dose of BNT162b2: Correlation with Age, Gender and BMI

Adipose Tissue Immunomodulation: A Novel Therapeutic Approach in Cardiovascular and Metabolic Diseases

An update on immune dysregulation in obesity‐related insulin resistance

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