Frequency of pre-diabetes, diabetes mellitus in non-alcoholic fatty liver disease.

Abstract

Objectives: To determine the prevalence of diabetes mellitus and pre-diabetes among patients with NAFLD having BMI ≥ 25 kg/m2and compare it with the control group with non-fatty liver with same BMI. Study Design: Prospective, Analytical and Cross-sectional study. Setting: Department of Medicine, Civil Hospital Karachi. Period: January 2015 to October 2016. Material & Methods: The study was conducted among two groups of patients, one with non-alcoholic fatty liver disease (NAFLD), having BMI of ≥25kg/m2and they were compared with a control group having BMI≥25kg/m2 but without fatty liver on ultrasound. Result: Out of 201 NAFLD participants, 82.08% had pre-diabetes and diabetes mellitus, while 82.51% of participants from non-NAFLD (n=101) had pre-diabetes or diabetes mellitus. Insulin resistance was more common among non-NAFLD group than NAFLD group. Most of the metabolic parameter analysed in the study among two groups having slight difference, and they were statistically significant. Conclusion: Pre-diabetes and diabetes mellitus is a frequently reported problem among NAFLD and overweight/obese patients. Insulin resistance was found to be a significant predictor of diabetes mellitus.

To Evaluate the Frequency of Diabetes Mellitus Patients with Hepatitis C at Tertiary Hospital of Sindh, Pakistan

“…According to numerous research studies, liver infections increased the glycemic level due to producing the insulin resistance but the mechanism is still unknown but the research studies recommend that there is direct interaction of Hepatitis with receptor of insulin via proinflammatory cytokines [9,10]. Ethawary et al had found in HCV sero-positive patients, 13.84% of patients had diabetes mellitus.…”