Frequency of Negative Sex Chromatin Among Women in Mental Hospitals

Åkesson, Hans Olof; Olanders, Staffan

doi:10.1159/000152197

Cited by 6 publications

(2 citation statements)

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“…The incidence was low, 10.3 per 1,000; however, this is 50 times higher than the expected general population frequency of such mosaicism. Further evidence for this hypothesis stems from the rare association of schizophrenia with Turner syndrome, the lack of an X chromosome, and reported isolated instances of psychosis in sex-chromatin-negative women (Mellbin 1965; Akesson and Olanders 1969). In addition to the implication of the X chromosome in schizophrenia, there is limited evidence for an excess of Y chromosomes (Crow et al 1989).…”

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confidence: 99%

Linkage Study of a Susceptibility Locus for Schizophrenia in the Pseudoautosomal Region

Barr

Kennedy

Pakstis

et al. 1994

Schizophrenia Bulletin

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Several lines of evidence suggest that the sex chromosomes have a role in the expression of schizophrenia. Gender differences in response to treatment, age at onset of illness, and prognosis indicate an influence of sex in differential expression of schizophrenia. On the basis of a higher-than-expected concordance for sex among siblings with schizophrenia, as well as the findings of cytogenetic abnormalities of the sex chromosomes in some schizophrenia patients, a pseudoautosomal location for a schizophrenia susceptibility locus has been proposed. To test this hypothesis, we investigated genetic linkage of the pseudoautosomal region to schizophrenia in a large Swedish kindred. Using pairwise analyses we tested eight markers spanning the most telomeric region to the boundary of the sex-specific region. In addition, we used multi-point analysis with five markers spanning the region to test for the presence of a schizophrenia susceptibility locus in the pseudoautosomal region. No evidence was found for linkage to schizophrenia under the given genetic model: "autosomal" dominant, f (penetrance) = 0.72, q (gene frequency) = 0.02, phenocopies = 0.001.

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confidence: 99%

Linkage Study of a Susceptibility Locus for Schizophrenia in the Pseudoautosomal Region

Barr

Kennedy

Pakstis

et al. 1994

Schizophrenia Bulletin

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show abstract

“…It is estimated that Turner's syndrome (TS) occurs in only 0.01% of newborn girls (Evans, 1977), with a relatively poor rate of survival into adult life (Forssman, 1970).The rate of sex chromatin-negative karyotype among female psychotics is even less common â€"¿ Akesson & Olanders (1969;quoted by Forssman, 1970) found only two cases among 6090 psychiatric patients.…”

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confidence: 99%