Frequency of Mycoplasma hominis and Ureaplasma urealyticum in Females With Urogenital Infections and Habitual Abortion History in Ahvaz, Iran; Using Multiplex PCR

Maleki, Saeed; Motamedi, Hossein; Moosavian, Mojtaba; Shahbaziyan, Nahid

doi:10.5812/jjm.10088

Cited by 9 publications

(6 citation statements)

References 17 publications

(18 reference statements)

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“…In the present study, in patients with primary infertility ( Table 3 ), analysis revealed that the highest prevalence of Mollicutes infection was that of M. hominis (12.6%) followed by U. urealyticum (6.8%) and M. genitalium (4.9%), whereas U. urealyticum (3.9%) possessed the highest prevalence of Mollicutes among patients with secondary infertility followed by M. genitalium and M. hominis (2.9%). This finding was in agreement with the previous report on recurrent (habitual) abortion in the presence of theses Mollicutes [ 23 ]. Bayoumi et al [ 24 ] also reported that M. hominis was detected in 30.4% of women with repeated pregnancy loss and not in pregnant women (as control) and the presence of M. hominis was observed more frequently in women with repeated abortions.…”

Section: Resultssupporting

confidence: 94%

“…It was also recorded that genital colonization with M. hominis and U. urealyticum may predispose to spontaneous abortion [ 22 ]. A previous study by Maleki et al [ 23 ] revealed a direct strong relationship between M. hominis and U. urealyticum and habitual abortion as well as urogenital infections. Furthermore, the role of Mollicutes in causing miscarriage is supported by treatment results of 5 female patients who had suffered from miscarriage and were included in our research.…”

Section: Resultsmentioning

confidence: 98%

“…Mollicutes distribution among the 2 genders in our study was different from that in another research, where, in our study, Mollicutes were detected in males more than in females. Maleki et al [ 23 ] revealed that the highest prevalence of M. hominis (71.4%) and U. urealyticum (60%) were in females. These differences may be attributed to cultural and religious variations in different regions.…”

Section: Resultsmentioning

confidence: 99%

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Prevalence of Certain Urogenital Bacterial Mollicutes in Patients Suffering from Infertility

Al-Masri

Ashour

Swafta

et al. 2022

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Introduction. Mollicutes urogenital tract infections are considered a possible cause of infertility worldwide. Genital Mollicutes infections are difficult and impractical to diagnose by culturing or serology. Mollicutes included in this study were Mycoplasma hominis, Ureaplasma urealyticum, and Mycoplasma genitalium. This cross-sectional study aimed to determine the prevalence of M. hominis, U. urealyticum, and M. genitalium genital infections among infertile males and females patients. Methods. This study included 103 patients who visited Al-Shunar Clinic in Nablus city in Palestine and diagnosed with infertility during January 2018 to October 2018. The semen, urine, and/or vaginal swab specimens collected from patients were examined by PCR for detection of M. hominis, U. urealyticum, and M. genitalium. Results. A total of 57 semen, 37 urine, and 16 vaginal swab specimens were collected. Out of the 110 examined specimens, 35 (31.8%) were PCR positive for at least one Mollicutes, which were 16 (14.6%) M. hominis, 11 (10%) U. urealyticum, and 8 (7.3%) M. genitalium. Significant association were found between infections of M. hominis and U. urealyticum ( P = 0.044 ) and between M. hominis and M. genitalium ( P = 0.005 ) infections. M. hominis infection was found in significantly ( P = 0.048 ) higher percentage in males (20.6%) in comparison with females (5.7%). On the other hand, M. genitalium infection rate in females (8.6%) was slightly higher than males (7.4%). M. hominis was more prevalent in all age groups except for patient’s age group 40–50 years old, where M. genitalium was more prevalent. M. hominis was also more prevalent in all occupation types and among all smokers. Conclusion. Urogenital infections caused by M. hominis, M. genitalium, and U. urealyticum could be a possible cause of infertility among patients with different age groups, genders, and occupations. Thus, more attention by infertility centers and physicians is required in adopting molecular methods for diagnosis of infections by these microorganisms.

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Section: Resultssupporting

confidence: 94%

Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Prevalence of Certain Urogenital Bacterial Mollicutes in Patients Suffering from Infertility

Al-Masri

Ashour

Swafta

et al. 2022

Canadian Journal of Infectious Diseases and Medical Microbiolog

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“…Peerayeh et al (2007) (27) reported that of the 377 patients studied, 141 samples (37.4%) were positive for U. urealyticum , which was higher than our results. A previous study from Ahvaz, Iran ( 28 ) showed that the prevalence of M. hominis and U. urealyticum in the genital samples of females were 6.4% and 13.6%, respectively. They showed that the highest prevalence of M. hominis (54.5%) and U. urealyticum (53.8%) was found in females within 28 - 33 and 34 - 39 years old.…”

Section: Discussionmentioning

confidence: 94%

Prevalence of Ureaplasma urealyticum and Mycoplasma hominis in High Vaginal Swab Samples of Infertile Females

Seifoleslami¹,

Safari²,

Khameneie³

2015

Iran Red Crescent Med J

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Background:Mycoplasma hominis and Ureaplasma urealyticum are important causative agents of vaginitis, cervicitis, postpartum sepsis, reproductive infections and infertility in both males and females.Objectives:According to the uncertain prevalence of U. urealyticum and M. hominis in Iranian infertile females, the present study was carried out to determine the prevalence of U. urealyticum and M. hominis in high vaginal swab samples of fertile and infertile females.Patients and Methods:A total of 350 high vaginal swab specimens were taken from fertile and infertile females. Samples were cultured and those that were positive for bacteria were subjected to the polymerase chain reaction (PCR) for further confirmation.Results:Of the 350 collected samples, eleven were positive for M. hominis (3.14%), fifteen were positive for U. urealyticum (4.28%) and five were positive for both of them (1.42%). Prevalence of U. urealyticum and M. hominis in the high vaginal parts of infertile females was higher than fertile females (P < 0.05). The results of traditional method were also confirmed, using the PCR amplification of urease gene of U. urealyticum and 16SrRNA gene of the M. hominis. Ureaplasma urealyticum and M. hominis had a higher prevalence in the high vaginal samples collected during the summer season.Conclusions:Considerable prevalence of M. hominis and U. urealyticum in the high vaginal swab samples of infertile females compared to the low prevalence in fertile females may suggest that these two pathogens can be cause infertility. Application of the PCR method is recommended for rapid and sensitive detection of M. hominis and U. urealyticum in high vaginal swab samples.

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“…The prevalence of UU has been reported to be 20% in South America, 41.9% in Italy, and 51.5% in Africa [ 14 ]. The highest prevalence of UU (53.8%) was detected in females between 34 and 39 years of age [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Analyses of human papillomavirus, Chlamydia trachomatis, Ureaplasma urealyticum, Neisseria gonorrhoeae, and co-infections in a gynecology outpatient clinic in Haikou area, China

Lü¹,

Zhao²,

Lu³

et al. 2023

BMC Women's Health

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Background The purpose of this study was to study the infection rates of Chlamydia trachomatis (CT), Ureaplasma urealyticum (UU), Neisseria gonorrhoeae (NG), and co-infections with human papillomavirus (HPV) in a hospital gynecology outpatient clinic in the Haikou region in 2021. Methods From January to December 2021, the Women and Children Medical Center of Hainan Province collected 2389 samples of cervical exfoliated cells and vaginal swab specimens from gynecologic outpatients. The samples were then analyzed descriptively for data, and the detection rate of each pathogen was tallied. All vaginal swabs were obtained for CT, UU, and NG DNA testing, and cervical exfoliated cells for HPV genotyping. Analyses were performed on the detection rate of each group. Results In 2389 samples, the frequencies of pathogen identification among the 2389 samples were as follows: UU (58.43%); HPV (17.29%); CT (7.99%); and NG (0.38%). HPV, CT, UU, and NG were detected in 33.33%, 22.55%, 77.45%, and 2.94% of individuals between 15 and 20 years of age, respectively. The detection rates of CT, UU, and NG were substantially greater in the HPV-positive group than the the HPV-negative group (P < 0.05). Conclusion Among gynecologic outpatients at a hospital in the Haikou area, the probability of mixed infections with genital tract pathogens in HPV-positive patients was higher compared to HPV-negative patients. Reproductive tract infections are becoming more prevalent in younger people, hence adolescent sexual health education needs improvement.

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Frequency of Mycoplasma hominis and Ureaplasma urealyticum in Females With Urogenital Infections and Habitual Abortion History in Ahvaz, Iran; Using Multiplex PCR

Cited by 9 publications

References 17 publications

Prevalence of Certain Urogenital Bacterial Mollicutes in Patients Suffering from Infertility

Prevalence of Certain Urogenital Bacterial Mollicutes in Patients Suffering from Infertility

Prevalence of Ureaplasma urealyticum and Mycoplasma hominis in High Vaginal Swab Samples of Infertile Females

Analyses of human papillomavirus, Chlamydia trachomatis, Ureaplasma urealyticum, Neisseria gonorrhoeae, and co-infections in a gynecology outpatient clinic in Haikou area, China

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