Frequency of Metabolic Syndrome and Other Complications of Obesity in Practice of a Child Endocrinologist

Otto, N.Yu.; Sagitova, G.R.; Ledyaev, M.Ya.

doi:10.19163/1994-9480-2018-3(67)-93-98

Cited by 4 publications

(2 citation statements)

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“…Метаболический синдром диагностировался в соответствии с рекомендациями Россий-ского медицинского общества по артериальной гипертонии (2013) [11]. Степень артериальной гипертензии определялась в соответствии с рекомендациями Европейского общества кардиологов и Европейского общества по артериальной гипертензии (2018) [4,8].…”

Section: материалы и методыunclassified

Predictors of Metabolic Syndrome Development Risk in Young Men With Abdominal Obesity

Церцвадзе,

Авдеева,

Щеглова

et al. 2023

Medicine: Theory and Practice

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Введение. Проблема изучения факторов риска развития метаболического синдрома у юношей призывного возраста приобретает особую актуальность на фоне глобальной эпидемии ожирения. Цель исследования. Определить частоту выявления метаболического синдрома и изучить предикторы его развития у юношей 18‒21 лет с абдоминальным ожирением. Материалы и методы. Обследовано 221 лицо мужского пола в возрасте 18−21 лет с абдоминальным ожирением (средний возраст 19,4 ± 1,2 лет). Результаты. В группе юношей с абдоминальным ожирением III степени метаболический синдром встречался чаще, чем при II степени (77,5 и 59,3 % соответственно; χ2 = 7,44; p = 0,0064) и при I степени абдоминального ожирения (77,5 и 3,9 %; χ2 = 113,2; p = 0,0000). Выявлены сильные корреляционные связи между количеством компонентов метаболического синдрома и уровнем систолического АД (r = 0,85; р < 0,05) и диастолического АД (r = 0,71; р < 0,05), уровнем высокочувствительного С-реактивного белка (r = 0,83; р < 0,05). Средняя корреляционная связь выявлена между количеством компонентов метаболического синдрома и показателями жирового обмена, уровнем инсулинорезистентности, дислипидемией, эндотелийзависимой вазодилатацией (r = 0,61; р < 0,05), индексом аугментации (r = 0,41; р < 0,05), возрастом сосудистой стенки (r = 0,38; р < 0,05), количеством циркулирующих эндотелиальных клеток (r = 0,61; р < 0,05), P-селектином (r = 0,55; р < 0,05); слабая связь выявлена с интерлейкином-6 (r = 0,22; р <0,05). Заключение. Развитие метаболического синдрома у юношей ассоциировано с повышением АД, метаболическими изменениями, структурно-функциональными нарушениями сосудистой стенки и вялотекущим воспалением. Background. The problem of studying risk factors for the development of metabolic syndrome in young men of military age is of particular relevance against the background of the global epidemic of obesity. Aims. To determine the frequency of detection of the metabolic syndrome and to study the predictors of its development in young men aged 18‒21 years with abdominal obesity. Materials and methods. We examined 221 males aged 18−21 years with abdominal obesity (mean age 19.4 ± 1.2 years). Results. In the group of boys with abdominal obesity of the 3rd degree, the metabolic syndrome occurred more often than in the 2nd degree (respectively: 77.5 % and 59.3 %; χ2 = 7.44; p = 0.0064) and in the 1st degree of abdominal obesity (77.5 % and 3.9 %; χ2 = 113.2; p = 0.0000). Strong correlations were found between the number of metabolic syndrome components and the level of systolic blood pressure (r = 0.85; p < 0.05) and diastolic blood pressure (r = 0.71; p < 0.05), the level of highly sensitive C-reactive protein (r = 0.83; p < 0.05). An average correlation was found between the number of metabolic syndrome components and indicators of fat metabolism, the level of insulin resistance, dyslipidemia, endothelium-dependent vasodilation (r = 0.61; p < 0.05), augmentation index (r = 0.41; p < 0.05), the age of the vascular wall (r = 0.38; p < 0.05), the number of circulating endothelial cells (r = 0.61; p < 0.05), P-selectin (r = 0.55; p < 0,05); interleukin-6 (r = 0.22; p < 0.05). Conclusions. The development of the metabolic syndrome in young men is associated with an increase in blood pressure, metabolic changes, structural and functional disorders of the vascular wall, and sluggish inflammation.

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Section: материалы и методыunclassified

Predictors of Metabolic Syndrome Development Risk in Young Men With Abdominal Obesity

Церцвадзе,

Авдеева,

Щеглова

et al. 2023

Medicine: Theory and Practice

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“…Hypothalamic syndrome is a consequence of primary immaturity of hypothalamic structures (Borovska-Stryuk 2018) or secondary dysfunction caused by structural and functional damage to the hypothalamus (Bereket et al 2012;Bereket et al 2015). Manifestations of the hypothalamic syndrome in the form of pink striae, tall, vegetative dysfunction can occur in 46-80% of obese children and adolescents (Ershevskaya et al 2018;Otto et al 2018). Over the past 20 years, the prevalence of hypothalamic syndrome of puberty has doubled (Tochilina 2018).…”

Section: Introductionmentioning

confidence: 99%

Hormonal Changes in the Hypothalamus-Pituitary-Adrenal- Gonads System in Young Men With Hypothalamic Obesity

2020

jcr

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Purpose of the study -to analyze the frequency and severity of hormonal changes in the hypothalamus-pituitary-adrenal-gonads system in young men with hypothalamic syndrome and alimentary-constitutional obesity. Materials and methods. We examined 340 males (mean age 21.27±2.44 years). Examined patients were divided into the following groups: Group I -hypothalamic syndrome of the late puberty (n=84); Group II -constitutional-exogenous obesity of the late puberty (n=20); Group III -hypothalamic syndrome of mature age (n=158); Group IV -constitutional-exogenous obesity of mature age (n=78). Results. In groups of patients with hypothalamic syndrome, a higher level of morning cortisol (р<0.05), evening cortisol (р<0.05), prolactin (р<0.05), luteinizing hormone (р<0.05), follicle-stimulating hormone (р<0.05) than in patients with constitutionally-exogenous obesity. In groups of patients with hypothalamic syndrome, lower testosterone levels were recorded than in patients with constitutionally-exogenous obesity (р<0.05). Violation of the daily rhythm of cortisol production was more common in patients with hypothalamic syndrome than in constitutionally-exogenous obesity (р<0.05). In groups of patients with hypothalamic syndrome, the incidence of high prolactin was higher than in groups of patients with constitutionally-exogenous obesity (p<0.05). In groups of patients with signs of hypothalamic syndrome, low testosterone levels were more common than with constitutionally exogenous obesity (p<0.05). Conclusion. The data obtained indicate a higher functional activity of the hypothalamus-pituitary-adrenal axis and lower functional activity of the hypothalamus-pituitary-gonads axis in patients with hypothalamic syndrome in comparison with patients with constitutionally-exogenous obesity.Keywords: hypothalamus dysfunction, hypothalamic obesity, obesity in adolescents, hormonal disorders in adolescents, hormonal disorders in young men

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Markers of endothelial dysfunction in adolescent and young patients with hypothalamic syndrome

et al. 2020

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Background: Endothelial dysfunction is the first but reversible stage of atherosclerosis. A change in the functional state of the vascular endothelium, especially of a growing organism, can be the basis for the development of many diseases in adulthood. The study of the structural and functional state of peripheral vessels of adolescents with hypothalamic syndrome is extremely important for understanding of the mechanisms of formation of cardiometabolic risks.Aims: to compare the structural and functional state of the vascular wall of young men with hypothalamic syndrome and constitutionally exogenous obesity.Methods: During the study 360 males were examined (average age 21.27±2.44 years) and divided into 3 groups: group 1 -with hypothalamic syndrome (n=242); group 2 - with constitutionally exogenous obesity (n=98); control group - practically healthy individuals (n=20). Hypothalamic syndrome was verified in the presence of a symptom complex, including obesity and pink striae. Cross-group comparative analysis of results of clinical, laboratory and instrumental examination was carried out.Results: In the group of patients with hypothalamic syndrome, endothelium-dependent vasodilatation (9.44±1.26 versus 10.37±1.21%; p=0.001) and endothelium-independent vasodilatation (10.29±1.28 versus 11.29±1.14%; p=0.001) is worse than in the group of patients with constitutionally exogenous obesity, and the rate of endothelium-dependent vasodilatation is lower than the generally accepted norm. In addition, among patients with hypothalamic syndrome, the stiffness of the vascular wall is higher than among patients with constitutionally exogenous obesity (15.47±2.58 versus 13.24±3.84%; p=0.001). Statistically significant correlations were revealed between the structural and functional state of peripheral arteries and hemodynamic, hormonal, metabolic changes, and the level of C-reactive protein (p<0.05).Conclusions: The obtained data indicate a deterioration of endothelial function and an increase in vascular wall stiffness in obese patients, regardless of its etiology. The patients with hypothalamic syndrome have more pronounced structural and functional changes in the vascular wall are observed than patients with constitutionally exogenous obesity.

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Frequency of Metabolic Syndrome and Other Complications of Obesity in Practice of a Child Endocrinologist

Cited by 4 publications

References 1 publication

Predictors of Metabolic Syndrome Development Risk in Young Men With Abdominal Obesity

Predictors of Metabolic Syndrome Development Risk in Young Men With Abdominal Obesity

Hormonal Changes in the Hypothalamus-Pituitary-Adrenal- Gonads System in Young Men With Hypothalamic Obesity

Markers of endothelial dysfunction in adolescent and young patients with hypothalamic syndrome

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