Frequency of metabolic abnormalities in urinary stones patients

Ahmad, Iftikhar; Pansota, Mudassar Saeed; Tariq, Muhammad; Tabassum, Shafqat Ali

doi:10.12669/pjms.296.4007

Cited by 6 publications

(2 citation statements)

References 10 publications

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“…Hyperoxaluria was present in 11.8% of our patients. The presence of hyperoxaluria reported in the literature ranges between 2.6% and 64.1% (8,10,(16)(17)(18)(19)(20)25), being the most frequent biochemical alteration found in some cases (10). Also, 11.9% of the patients had hyperphosphaturia.…”

Section: Discussionmentioning

confidence: 99%

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Biochemical Alterations in Patients with Oxalocalcic Lithiasis, the Influence of Sex, Age, and Body Mass Index

et al. 2020

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Background: Urolithiasis is a disorder that has a high prevalence in the population. Also, lithiasic patients have biochemical alterations that predispose them to the formation of stones. The knowledge of these alterations may be useful for future preventive interventions. Objectives: The objectives were to describe the metabolic characteristics of patients with oxalocalcic lithiasis, identifying the most frequent biochemical alterations, and their variation with different demographic variables. In this way, we can prevent the formation of the lithiasis before it appears, instead of treating it once established. Methods: A descriptive cross-sectional study of serum and 24 hour-urine parameters in patients with oxalocalcic lithiasis was performed. The most frequent biochemical alterations were described, and their association with age, sex, and body mass index (BMI) were assessed. Results: In this study, 100% of the 151 patients had biochemical alterations, the most frequent being hypocitraturia (84.7%), hypercalciuria (51.7%), and urinary pH decrease (44.4%). There were differences according to sex, age, and BMI with regard to the biochemical alterations. Hypouricemia, hypouricosuria, hypophosphaturia and hypomagnesuria were more frequent in women. Men had a higher percentage of hyperzinquemia, hyperphosphaturia, and excess of urinary urea. Urine density in men was slightly higher than in women. A higher percentage of hyperphosphaturia, excess urinary urea, and excess of serum urea was found in overweight patients. Patients not overweight showed a higher percentage of hypouricemia and hypomagnesuria. Urinary density was slightly higher in overweight patients. Urinary volume was higher in middle-aged subjects. Conclusions: Patients with oxalocalcic lithiasis have biochemical alterations that may predispose to stone formation. These alterations vary with sex, age, and BMI.

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Section: Discussionmentioning

confidence: 99%

“…The percentage of urolithiasic patients with biochemical alterations ranges between 90.5% and 96.8% in the literature (8)(9)(10)(16)(17)(18). In addition, usually, more than one biochemical alteration was found in each patient (8)(9)(10)(16)(17)(18). In our study, 100% of the patients presented biochemical alterations.…”

Section: Discussionmentioning

confidence: 99%

Biochemical Alterations in Patients with Oxalocalcic Lithiasis, the Influence of Sex, Age, and Body Mass Index

et al. 2020

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Urinary Calculi: A Microbiological and Biochemical Analysis at a Tertiary Care Hospital in Eastern Nepal

Shah

Baral

Agrawal

et al. 2020

International Journal of Microbiology

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Background. The occurrence of urinary tract infection in presence of urolithiasis is frequently noted; however, microbial agents of urolithiasis and their antimicrobial susceptibility patterns remain underinvestigated. This study aimed to identify the microorganisms isolated from urine and stone matrices to determine their antimicrobial susceptibility, to find the association between the pathogens of urine and stone matrices, and to perform the biochemical analysis of stones. Methods. A total of 88 cases of urolithiasis admitted for elective stone removal at Department of surgery, B.P. Koirala Institute of Health Sciences (BPKIHS), were enrolled. Preoperative urine culture and postoperative stone culture were performed. Isolation, identification, and AST were done by the standard microbiological technique. Further qualitative biochemical analysis of stones was also attempted. Result. Among 88 stone formers recruited, culture of urine, whole stone, and nidus yielded the growth of bacteria 44, 32, and 30, respectively. Bacteria isolated from urine culture correlated with those from stone matrices with a sensitivity of 90%, specificity of 79.69%, PPV of 63.64%, and NPV of 95.45%. Escherichia coli (46.7%) was the most common bacteria followed by Klebsiella pneumoniae (16.7%) and Proteus mirabilis (13.3%) from urine and stone cultures. Almost all the uropathogens isolated were susceptible to commonly used antibiotics. Calcium oxalate (84.1%) was common biochemical constituent found in stone formers followed by calcium oxalate + phosphate (8%). Conclusions. The association of microorganism isolated from urine and nidus culture was significant that can predict the source of infective stone; however, in some cases, microorganisms and the antimicrobial susceptibility pattern from urine and nidus were different. This study emphasizes the use of appropriate antimicrobial agents to prevent the regrowth of residual stones and minimize the risk of infectious complications after surgical removal of stones.

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Do Hypertension, diabetes mellitus and obesity increase the risk of severity of nephrolithiasis?

Sancak¹,

Reşorlu²,

Akbaş³

et al. 1969

Pak J Med Sci

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Objective:In this study we planned to investigate the relationship between presence of kidney stones and stone burden with hypertension (HT), diabetes mellitus (DM) and body mass index (BMI).Methods:A total of 574 patients were included in the study. None of the patients had a history of stones. The 121 patients with kidney stone identified on ultrasound evaluation and the 453 patients with no stones were compared in terms of HT, BMI and DM. The stone burden of 121 patients with diagnosed stones was compared in terms of the same variables.Results:Of the 121 patients with kidney stones 30 (24.7%) had HT, while 66 (14.5%) of the 453 patients without stones had HT (p=0.007). BMI values of those with and without stones were 27.2 ± 4.93 kg/m2 and 25.29 ± 4.12 kg/m2, respectively (p<0.001). Twenty-five (20.6%) of the patients with stones diagnosed by ultrasound had DM, while 49 (10.8%) of those without stones had DM (p=0.004). When comparing patients with and without kidney stones, logistic regression analysis revealed that DM (odds ratio [OR] 2.06, 95% confidence interval [CI] 1.17 to 3.63, p=0.013) and BMI (OR 1.08, CI 1.03 to 1.13, p=0.003) were independently associated with presence of stones. No significant relationship was found between the same variables and cumulative stone diameter (CSD) and stone surface area (SA) evaluated for stone burden.Conclusions:While diabetes mellitus, Hypertension and increased Body Mass Index may add to the possibility of stone formation, they did not affect stone burden.

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Frequency of metabolic abnormalities in urinary stones patients

Cited by 6 publications

References 10 publications

Biochemical Alterations in Patients with Oxalocalcic Lithiasis, the Influence of Sex, Age, and Body Mass Index

Biochemical Alterations in Patients with Oxalocalcic Lithiasis, the Influence of Sex, Age, and Body Mass Index

Urinary Calculi: A Microbiological and Biochemical Analysis at a Tertiary Care Hospital in Eastern Nepal

Do Hypertension, diabetes mellitus and obesity increase the risk of severity of nephrolithiasis?

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