Frequency of menstrual abnormalities and their associated neuroimaging findings in women with focal refractory epilepsy

Ranjbar, Mahta; Habibabadi, Jafar Mehvari; Poorazarian, Farinaz; Mohammadi, Banafshe; Naghibi, Seyed Navid; Tabrizi, Nasim

doi:10.1007/s13760-020-01374-7

Cited by 1 publication

(1 citation statement)

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“…A large number of reports have reported an increase in the incidence of menstrual disorders in patients with epilepsy or VPA treatment. The incidence of epilepsy in women is about 20%-35%, and even as high as 48% (39,(113)(114)(115). It can manifest as irregular menstrual cycles, oligomenorrhea, polymenorrhea, and even amenorrhea (5,15,39).…”

Section: The Possible Mechanism Of Ovulation Disorder and Polycystic Ovary Induced By Vpamentioning

confidence: 99%

Research Progress on the Effect of Epilepsy and Antiseizure Medications on PCOS Through HPO Axis

Zhang

Wei

et al. 2021

Front. Endocrinol.

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Epilepsy is a common chronic neurological disease that manifests as recurrent seizures. The incidence and prevalence of epilepsy in women are slightly lower than those in men. Polycystic ovary syndrome (PCOS), a reproductive endocrine system disease, is a complication that women with epilepsy are susceptible to, and its total prevalence is 8%–13% in the female population and sometimes as high as 26% in female epilepsy patients. The rate of PCOS increased markedly in female patients who chose valproate (VPA), to 1.95 times higher than that of other drugs. In addition, patients receiving other anti-seizure medications (ASMs), such as lamotrigine (LTG), oxcarbazepine (OXC), and carbamazepine (CBZ), also have reproductive endocrine abnormalities. Some scholars believe that the increase in incidence is related not only to epilepsy itself but also to ASMs. Epileptiform discharges can affect the activity of the pulse generator and then interfere with the reproductive endocrine system by breaking the balance of the hypothalamic–pituitary–ovarian (HPO) axis. ASMs may also cause PCOS-like disorders of the reproductive endocrine system through the HPO axis. Moreover, other factors such as hormone metabolism and related signalling pathways also play a role in it.

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Section: The Possible Mechanism Of Ovulation Disorder and Polycystic Ovary Induced By Vpamentioning

confidence: 99%

Research Progress on the Effect of Epilepsy and Antiseizure Medications on PCOS Through HPO Axis

Zhang

Wei

et al. 2021

Front. Endocrinol.

View full text Add to dashboard Cite

show abstract

Frequency of menstrual abnormalities and their associated neuroimaging findings in women with focal refractory epilepsy

Cited by 1 publication

References 24 publications

Research Progress on the Effect of Epilepsy and Antiseizure Medications on PCOS Through HPO Axis

Research Progress on the Effect of Epilepsy and Antiseizure Medications on PCOS Through HPO Axis

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