Frequency of low serum high-density lipoprotein cholesterol levels in hospitalized patients with “desirable” total cholesterol levels

Ginsburg, Geoffrey S.; Safran, Charles; Pasternak, Richard C.

doi:10.1016/0002-9149(91)90742-4

Cited by 61 publications

(11 citation statements)

References 17 publications

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“…Epidemiological studies have shown that among the various lipid risk factors of coronary artery disease, decreased HDL is the strongest predictor for clinical endpoints 23 . Decreased HDL values are predictive of coronary artery disease even when total cholesterol values are not elevated 24 . Furthermore, data from the Helsinki Heart Study suggest that treatments that increase HDL are associated with a decreased incidence of coronary artery disease 25 .…”

Section: Discussionmentioning

confidence: 99%

Long term influence of different postmenopausal hormone replacement regimens on serum lipids and lipoprotein(a): a randomised study

Hänggi

Lippuner

Riesen

et al. 1997

BJOG

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Objective To assess the influence of three different postmenopausal hormone replacement therapies on Design Open, randomised, controlled study.Participants One hundred and forty healthy, early postmenopausal women.Interventions The women were randomised to receive continuous 17P-oestradiol, either orally (2 mg daily; n = 35) or transdermally (50 pg daily; n = 35), plus 10 mg dydrogesterone daily for 14 days of each 28-day cycle; or 2-5 mg tibolone daily (n = 35). Thirty-five untreated women acted as controls. Results At 24 months oral oestradiol increased mean HDL cholesterol (7%; 95% CI 1-14), compared with no change in the transdermal group and a decrease of 26.8% in the tibolone group (95% CI 22.9-30.5); oral oestradiol decreased mean LDL cholesterol (1 1.8%; 95% CI 6*3-19), compared with no change in the tibolone group. Changes in apolipoprotein A-1 and B showed a similar pattern to HDL and LDL cholesterol, respectively. Oral oestradiol increased serum triglycerides (30%; 95% CI 18-42) after 24 months, compared with no change in the tibolone and transdermal oestradiol groups. Tibolone decreased serum Lp(a) by 36.6% after 24 months (95% CI 8-3-56-2), oral oestradiol decreased levels by 29.4% (95% CI 2-5 1-1), compared with no change in the transdermal oestradiol group. Main outcome measures

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Section: Discussionmentioning

confidence: 99%

Long term influence of different postmenopausal hormone replacement regimens on serum lipids and lipoprotein(a): a randomised study

Hänggi

Lippuner

Riesen

et al. 1997

BJOG

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“…12 Thus, the ability to adequately identify individuals at high risk of CVD solely on the basis of TC/HDL is at variance with evidence showing that up to 50% of subjects with CVD may have clinically acceptable values for these lipids. [13][14][15][16][17] Data also indicates that patients undergoing cholesterol-lowering treatments who achieve a significant decrease in low-density liproprotein-cholesterol (LDL-C) levels nonetheless carry risk for CVD. 18 Using polyacrylamide gel electrophoresis, data further suggest that patients with visceral adiposity often possess greater proportion of small, dense, cholesterol depleted LDL-C particles than total cholesterol and LDL-C. 19 Indeed, it has been estimated that patients with visceral obesity have 15-20% higher than normal plasma ApoB levels despite having normal total cholesterol and LDL-C. 13 Thus, ApoB concentration in abdominally obese subjects could be a more potent atherogenic marker for predicting CVD than conventional lipids.…”

Section: Introductionmentioning

confidence: 99%

Apolipoprotein B, ratio of total cholesterol to HDL-C, and blood pressure in abdominally obese white and black American women

et al. 2001

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“…9 -11 Previous studies from our laboratory have shown that subjects with isolated low HDL cholesterol were neither characterized by hyperinsulinemia nor by visceral obesity. 12 Although studies have suggested that patients with isolated low HDL cholesterol syndrome may be at increased CHD risk, 9,10,13,14 it appears very difficult to increase HDL cholesterol levels in these individuals by diet, weight loss, or pharmacotherapy. 15 …”

mentioning

confidence: 99%

Effects of Endurance Exercise Training on Plasma HDL Cholesterol Levels Depend on Levels of Triglycerides

Couillard

Després

Lamarche

et al. 2001

ATVB

251

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Abstract-High density lipoprotein (HDL) cholesterol concentrations have been shown to increase with regular endurance exercise and, therefore, can contribute to a lower risk of coronary heart disease in physically active individuals compared with sedentary subjects. Although low HDL cholesterol levels are frequently observed in combination with hypertriglyceridemia, some individuals may be characterized by isolated hypoalphalipoproteinemia, ie, low HDL cholesterol levels in the absence of elevated triglyceride (TG) concentrations. The present study compared the responses of numerous lipoprotein-lipid variables to a 20-week endurance exercise training program in men categorized on the basis of baseline TG and HDL cholesterol concentrations: (1)

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Frequency of low serum high-density lipoprotein cholesterol levels in hospitalized patients with “desirable” total cholesterol levels

Cited by 61 publications

References 17 publications

Long term influence of different postmenopausal hormone replacement regimens on serum lipids and lipoprotein(a): a randomised study

Long term influence of different postmenopausal hormone replacement regimens on serum lipids and lipoprotein(a): a randomised study

Apolipoprotein B, ratio of total cholesterol to HDL-C, and blood pressure in abdominally obese white and black American women

Effects of Endurance Exercise Training on Plasma HDL Cholesterol Levels Depend on Levels of Triglycerides

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