Frequency of iridocyclitis in patients with early psoriatic arthritis: a prospective, follow up study

Niccoli, Laura; Nannini, Carlotta; Cassarà, Emanuele; Kaloudi, Olga; Susini, Massimo; Lenzetti, Ivo; Cantini, Fabrizio

doi:10.1111/j.1756-185x.2012.01736.x

Cited by 58 publications

(48 citation statements)

References 19 publications

(33 reference statements)

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“…Besides skin symptoms, the most frequent extra-articular manifestation of psoriatic arthritis is uveitis, which affects between 1.5% and 25% of patients. 17 Uveitis presents as an acute, painful red eye, accompanied by photophobia and blurred vision. If uveitis is suspected, immediate referral to an ophthalmologist is required because if not treated promptly, uveitis can lead to serious consequences, including vision loss.…”

Section: ■ Pathophysiologymentioning

confidence: 99%

Management of patients with psoriatic arthritis

Dewing¹

2015

The Nurse Practitioner

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Section: ■ Pathophysiologymentioning

confidence: 99%

Management of patients with psoriatic arthritis

Dewing¹

2015

The Nurse Practitioner

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“…A series that includes long follow-up will generally find a higher prevalence of uveitis relative to other reports. In comparison, uveitis affects roughly 2 to 5 % of patients with inflammatory bowel disease [9][10][11][12][13] and approximately 7 % of patients with psoriatic arthritis [14,15]. Uveitis in association with ankylosing spondylitis affects males slightly more commonly than females [5].…”

Section: Uveitis Prevalence In Spondyloarthritismentioning

confidence: 99%

Uveitis in spondyloarthritis including psoriatic arthritis, ankylosing spondylitis, and inflammatory bowel disease

Rosenbaum

2015

Clin Rheumatol

100

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Uveitis is a common complication of spondyloarthritis. The "phenotype" of the uveitis characteristic of ankylosing spondylitis (sudden onset, anterior, unilateral, recurrent, more often male) may differ from the phenotype often seen with either psoriatic arthritis or inflammatory bowel disease (insidious onset, anterior and intermediate, bilateral, chronic, and/or more often female). The frequency of uveitis is also much greater in association with ankylosing spondylitis than with either inflammatory bowel disease or psoriasis. Uveitis may affect the choice of therapy and can rarely be a complication of therapy. Uveitis and arthritis also co-exist in several animal models.

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“…[8][9][10] Furthermore, no data exist on the risks for psoriasis or psoriatic arthritis in patients with uveitis. We therefore examined the risk for incident (new-onset) uveitis in patients with mild psoriasis, severe psoriasis, and psoriatic arthritis and for the reverse relationship in patients with uveitis in a nationwide cohort of the Danish population.…”

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confidence: 98%

Association of Psoriatic Disease With Uveitis

et al. 2015

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IMPORTANCE Psoriasis, psoriatic arthritis, and uveitis are inflammatory disorders with significant overlap in their inflammatory pathways. Limited evidence is available about the relationship between psoriatic disease and uveitis.OBJECTIVE To investigate the potential bidirectional relationship between psoriatic disease, including psoriasis and psoriatic arthritis, and uveitis. DESIGN, SETTING, AND PARTICIPANTSWe performed a nationwide cohort study of the Danish population from January 1, 1997, through December 31, 2011. We included 74 129 Danish patients with psoriasis who were 18 years or older during the study period. Patients were identified through administrative registries, and information on age, sex, socioeconomic status, medication, and comorbidity was obtained using individual-level linkage of administrative registers. We performed data analysis from January 27 through March 4, 2015.EXPOSURES Diagnosis of mild or severe psoriasis or psoriatic arthritis for uveitis risk and diagnosis of uveitis for the risk for psoriasis or psoriatic arthritis.MAIN OUTCOMES AND MEASURES Diagnosis of uveitis, mild psoriasis, severe psoriasis, or psoriatic arthritis. We calculated incidence rates (IRs) and estimated IR ratios adjusted for potential confounders using Poisson regression. RESULTSWe identified 74 129 cases of psoriasis and psoriatic arthritis and 13 114 cases of uveitis. The IRs (95% CIs) for uveitis were 2.02 (1.99-2.06), 2.88 (2.33-3.56), 4.23 (2.40-7.45), and 5.49 (3.36-8.96) for the reference population and those with mild psoriasis, severe psoriasis, and psoriatic arthritis, respectively. In the reference population, these IRs (95% CIs) were 9.37 (9.30-9.45), 1.12 (1.10-1.15), and 1.04 (1.01-1.06), and in patients with uveitis, these statistics were 15.51 (12.92-18.62), 2.66 (1.72-4.13), and 4.25 (3.00-6.01) for mild psoriasis, severe psoriasis, and psoriatic arthritis, respectively. Adjusted IR ratios (95% CIs) for uveitis were 1.38 (1.11-1.70 [P = .02]), 1.40 (0.70-2.81 [P = .34]), and 2.50 (1.53-4.08 [P < .001]) for patients with mild psoriasis, severe psoriasis, and psoriatic arthritis, respectively. For patients with uveitis, IR ratios (95% CIs) were 1.59 (1.32-1.91 [P < .001]) for mild psoriasis, 2.17 (1.40-3.38 [P < .001]) for severe psoriasis, and 3.77 (2.66-5.34 [P < .001]) for psoriatic arthritis, respectively. CONCLUSIONS AND RELEVANCEWe found a bidirectional association between psoriatic disease and uveitis. Increased focus on eye symptoms in patients with psoriasis and psoriatic arthritis and on skin and joint symptoms in patients with prior or current uveitis may be appropriate.

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Frequency of iridocyclitis in patients with early psoriatic arthritis: a prospective, follow up study

Abstract: IC occurred in 9% of 242 patients with early PsA with no association with the clinical pattern and B27 positivity. This frequency is higher than previously reported.

Cited by 58 publications

References 19 publications

Management of patients with psoriatic arthritis

Management of patients with psoriatic arthritis

Uveitis in spondyloarthritis including psoriatic arthritis, ankylosing spondylitis, and inflammatory bowel disease

Association of Psoriatic Disease With Uveitis

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