Frequency of hyaline membrane disease in preterm infants after prenatal corticosteroid prophylaxis

Bakova, Desislava; Gueorguiev, Stanislav; Parahuleva, N; Karaslavova, E.; Sandeva, Milena; Gueorguieva, Elina Petkova; Ivanova, Stanislava; Ivanov, Kalin; Uchicova, Ekaterina

doi:10.4066/biomedicalresearch.29-17-3642

Cited by 3 publications

(6 citation statements)

References 8 publications

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“…In this study Pearson chi-square test p value highly significant of female gender with complications of HMD. Outcome newborns of hyaline membrane disease were dead in more than half of the sample (52%), Bulgaria study in 2018 mentioned the goal of effective corticosteroid prophylaxis is to reduce mortality, reduce complications in prenatal new-born babies same results in this study in which Dexamethasone was used [25].…”

Section: Discussionsupporting

confidence: 53%

“…A retrospective study of 167 preterm infants was conducted, of which 89 (53.3%) had prophylaxis with Dexamethasone, in 25 (15%) of preterm infants, there was a Hyaline Membrane Disease (HMD) and 101 (60.5%) developed other forms of Respiratory Distress Syndrome (RDS). The results obtained show that the incidence of HMD in preterm infants is mediated by the early gestational age and advanced age of the mother, and decreased by corticosteroid therapy [25]. The study showed that the premature birth is a serious medical, social and economic problem.…”

Section: Currently Recommended Treatment Modalities For Hmd Include Oxygen Therapy Continuousmentioning

confidence: 80%

“…The study also reported that in prenatal and neonatal medicine, new and adaptive prophylaxis is being implemented to reduce the risk of death of premature babies and reduce the development of health complications, the study also mentioned the goal of effective corticosteroid prophylaxis is to reduce mortality, reduce complications in prenatal newborns, and shorten their stay in neonatal and intensive units respectively [25].…”

Section: Currently Recommended Treatment Modalities For Hmd Include Oxygen Therapy Continuousmentioning

confidence: 98%

“…Respiratory insufficiency and surfactant deficiency significantly increase the risk of developing Hyaline Membrane Disease (HMD) and other forms of Respiratory Distress (RDS). These are the most common causes of death in premature babies [25].…”

Section: Currently Recommended Treatment Modalities For Hmd Include Oxygen Therapy Continuousmentioning

confidence: 99%

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The Magnitude and Risk Factors of Acute Respiratory Distress Syndrome among Newborn Admitted To Neonatal Intensive Care Unit at Benghazi Medical Center

Radwan

El-Mansori

Elfergani

et al. 2021

AJMAH

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Background: Hyaline Membrane Disease (HMD)/Respiratory Distress Syndrome (RDS) is the most common lung condition affecting premature babies. The inadequate amount of surfactant causes alveoli to collapse when the baby breathes out. It is hard for your baby to re-inflate the collapsed alveoli when he breathes. The lack of surfactant and resulting inflammation is called. Hyaline Membrane Disease (HMD)/Respiratory Distress Syndrome (RDS). Aim of the Study: To determine the magnitude of Hyaline membrane disease or respiratory distress syndrome and identify the risk factors and complication among newborn babies in neonatal intensive care unit at Benghazi medical center (BMC). Materials and Methods: Case series study. The study was conducted during the period between March 2017 to March 2018 of HMD cases at Benghazi medical center. A convenient sample of 120 cases diagnosed as HMD. Studied variables include the following; gestational age, birth weight, gender, type of pregnancy and type of delivery also the data for mothers such as (diabetes mellitus, preeclampsia hypothyroidism, receiving of Dexamethasone injection and premature rupture of membrane). Also investigation and treatment and finally the outcomes of babies. Statistical Methods: Data were analyzed with SPSS version 17, analysis of associations was made with application Chi - square test for categorical variables comparison, was applied for test of association P <0.25. P was considered statistically significant if ≤ 0.05. Results: Female gender was predominant (52%). Most of cases of HMD were between 1000 -2000 kg. Among the 120 cases we have (15%) sever HMD and the majority of cases have moderate –to sever Hyaline membrane disease 39 (32.5%) whereas very sever HMD were observed in nearly 27% of cases. The risk factors were history of maternal preeclampsia, maternal diabetes mellitus, prematurity and low birth weight babies and neonatal sepsis, all these were found to be very common risk factors of HMD. Pearson chi-square test p value highly significant of female gender with complications of HMD. Our results observed more than half of babies were died. Conclusion: The risk factors were history of maternal preeclampsia, maternal diabetes mellitus, prematurity and low birth weight babies and neonatal sepsis all these were found to be very common risk factors of HMD. Also we concluded that the cases had premature rupture of membrane, which identified as risk factors of hyaline membrane disease. Furthermore, we concluded that highly significant of female gender with complications of HMD, such as Pneumothorax, bronco pulmonary, dysplasia, intra ventricular hemorrhage and congenital heart diseases were common co- morbidities with respiratory distress syndrome, all these could be have an association with the development of hyaline membrane disease, finally we observed more than half of babies were died this is a warning sign for health services.

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Section: Discussionsupporting

confidence: 53%

Section: Currently Recommended Treatment Modalities For Hmd Include Oxygen Therapy Continuousmentioning

confidence: 80%

Section: Currently Recommended Treatment Modalities For Hmd Include Oxygen Therapy Continuousmentioning

confidence: 98%

Section: Currently Recommended Treatment Modalities For Hmd Include Oxygen Therapy Continuousmentioning

confidence: 99%

See 2 more Smart Citations

The Magnitude and Risk Factors of Acute Respiratory Distress Syndrome among Newborn Admitted To Neonatal Intensive Care Unit at Benghazi Medical Center

Radwan

El-Mansori

Elfergani

et al. 2021

AJMAH

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“…In this study proportion of hyaline membrane disease was 40%, this is consistent with study conducted in Iraq, 42.2% [ 17 ], in Black lion Hospital, Ethiopia 42.9% [ 41 ]. But, higher than study conducted in Nigeria, 26.2% [ 14 ], in Bulgaria, 15% [ 42 ], in Nepal 17.8% [ 43 ], in Jimma Ethiopia 11.9% [ 20 ].This could be the current study include only preterm neonates. In addition, the study conducted in Bulgaria was conducted among preterm neonate whose mother took dexamethasone.…”

Section: Discussionmentioning

confidence: 94%

The burden of hyaline membrane disease, mortality and its determinant factors among preterm neonates admitted at Debre Tabor General Hospital, North Central Ethiopia: A retrospective follow up study

et al. 2021

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Background Hyaline membrane disease (HMD) is a leading cause of morbidity and mortality in preterm newborn babies. Though, there are studies related to Hyaline membrane disease inclusive of all neonates, studies related to the burden among preterm neonates were limited. In addition, increasing neonatal mortality in Ethiopia could be related to increase in the burden of hyaline membrane disease among preterm neonates. Therefore, this study was aimed to assess the burden of hyaline membrane disease, mortality and its associated factors among preterm neonate admitted at neonatal intensive care unit, North Central Ethiopia. Methodology An institution-based retrospective follow-up study was conducted among 535 preterm neonates admitted at neonatal intensive care unit from January 1, 2014-December 30, 2017. Data were entered into EPi-data 4.2.0.0 and transferred to STATA version 14 statistical software for statistical analysis. Binary logistic regression was used for the analysis. All variables with P-value < 0.25 during bi-variable analysis were considered for multivariable logistic regression. Level of statistical significance was declared at P value ≤0.05. Results In the current study, proportion of hyaline membrane disease was 40% (95% CI; 35.8, 44.3) of which 49.5% died. Preterm neonate born with Gestational age of less than 34 weeks of age (Adjusted odd ratio (AOR = 2.64; 95 CI: 1.49, 4.66)), 5th minute Apgar score less than 7 (AOR = 2.2; 95% CI: 1.20, 4.07), and newborn with birth weight of less than 1500 gram (AOR = 2.4, 95% CI: 1.3, 4.3) were predictors of hyaline membrane disease. Conclusions The mean gestational age (±) was 33.46 (±2.55) weeks. The incidence of hyaline membrane disease among preterm admissions was high. Preterm neonate born with gestational age of less than 34 weeks of age, asphyxiated newborns and newborn with birth weight of less than 1500 gram were predictors of hyaline membrane disease. So, emphasis should be given on early screening, follow up and timely interventions for preterm neonate.

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Prevalence and Missed Cases of Respiratory Distress Syndrome Disease Amongst Neonatal Deaths Enrolled in the Kenya Child Health and Mortality Prevention Surveillance Network (CHAMPS) Program Between 2017 and 2021

Owuor,

Akelo,

Murila

et al. 2023

Global Pediatric Health

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Objectives. To describe RDS in neonatal deaths at the CHAMPS-Kenya site between 2017 and 2021. Methods. We included 165 neonatal deaths whose their Causes of death (COD) were determined by a panel of experts using data from post-mortem conducted through minimally invasive tissue specimen testing, clinical records, and verbal autopsy. Results. Twenty-six percent (43/165) of neonatal deaths were attributable to RDS. Most cases occurred in low birthweight and preterm neonates. From these cases, less than half of the hospitalizations were diagnosed with RDS before death, and essential diagnostic tests were not performed in most cases. Most cases received suboptimal levels of supplemental oxygen, and critical interventions like surfactant replacement therapy and mechanical ventilation were not adequately utilized when available. Conclusion. The study highlights the urgent need for improved diagnosis and management of RDS, emphasizing the importance of increasing clinical suspicion and enhancing training in its clinical management to reduce mortality rates.

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Frequency of hyaline membrane disease in preterm infants after prenatal corticosteroid prophylaxis

Cited by 3 publications

References 8 publications

The Magnitude and Risk Factors of Acute Respiratory Distress Syndrome among Newborn Admitted To Neonatal Intensive Care Unit at Benghazi Medical Center

The Magnitude and Risk Factors of Acute Respiratory Distress Syndrome among Newborn Admitted To Neonatal Intensive Care Unit at Benghazi Medical Center

The burden of hyaline membrane disease, mortality and its determinant factors among preterm neonates admitted at Debre Tabor General Hospital, North Central Ethiopia: A retrospective follow up study

Prevalence and Missed Cases of Respiratory Distress Syndrome Disease Amongst Neonatal Deaths Enrolled in the Kenya Child Health and Mortality Prevention Surveillance Network (CHAMPS) Program Between 2017 and 2021

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