Frequency of human parvovirus B19 infection in intrauterine fetal death

Tolfvenstam, Thomas; Papadogiannakis, Nikos; Norbeck, Oscar; Petersson, Karin; Broliden, Kristina

doi:10.1016/s0140-6736(00)04647-x

Cited by 213 publications

(115 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In our study, B19 DNA was detected in 1 (20%) of 5 cases, which was higher than the rates reported by Tolfvenstaml (15%), Skjoldebrand-Sparre (7.5%) and Petersson (3.8%). However, the number of cases (5) in our series is rather low (30,34,35). In our study, 51% (24/47) of normal pregnant women in the control group were positive for B19 IgG antibodies.…”

Section: Discussioncontrasting

confidence: 48%

“…In other studies conducted in China, the incidence of B19 in spontaneous abortus cases has been reported between 24.5% and 29.3% (31-33). Tolfvenstam reported lower rate (5%) of B19 DNA (30). In our study, B19 infection was diagnosed in 9 (33%) of maternal serum samples from 27 spontaneous abortus cases.…”

Section: Discussionmentioning

confidence: 42%

“…The rate of anti-B19 IgM antibody found by Kishore in 116 pregnant women with unknown recurrent spontaneous abortion was 19.8% (29). In the study by Tolfvenstam, B19 DNA was detected in 5% of 37 spontaneous abortus cases (<22 gestation week), but in none of 29 cases of induced abortion cases (30). In our study, 6 (31.5%) of 19 spontaneous abortus cases were found to have B19 DNA, which is similar to result (31.6%) of Salakwy, but lower than the rate (48%) detected by El-sayed Zaki (27,28).…”

Section: Discussionmentioning

confidence: 93%

See 2 more Smart Citations

The effects of Parvovirus B19 infection on pregnant women and fetus

Yarkın¹,

Şeflek²,

Sapmaz³

et al. 2017

J Immunol Clin Microbiol

View full text Add to dashboard Cite

Background: Human parvovirus B19 infection during pregnancy may cause fetal loss. The aim of this study was to detect the incidence of B19 infection in cases of nonimmune hydrops fetalis (NIHF), spontaneous abortion, intrauterine fetal death (IUFD) and in healthy pregnant women. Material and Methods: Serum samples of pregnant women with NIHF (9), spontaneous abortion (27), IUFD (5) and healthy pregnant women (47) were tested by nested PCR to detect B19 DNA and by ELISA test for B19 specific IgM and IgG antibodies. In other case series of the study, paraffin-embedded fetal and placental tissue samples from 33 NIHF cases and 19 spontaneous abortion cases and placental tissues from 40 normal pregnant women at term were analyzed for B19 DNA by nested PCR. Results: B19 infection was diagnosed by PCR and ELISA tests using serum samples in 4 (44%) of 9 NIHF cases and 9 (33%) of 27 spontaneous abortion cases and in 1 (20%) of 5 IUFD cases. In addition, B19 IgG prevalence was found to be 51% (24/47) in the control group. In other case series, the presence of B19 DNA in fetal and placental tissue samples was found in 14 (42.4%) of 33 NIHF cases and 6 (31.5%) of 19 spontaneous abortion cases, while in none of 40 placental tissues samples from the control group. Conclusion: Our findings show that the incidence of parvovirus B19 infection in NIHF and spontaneous abortion cases is relatively high. Nested PCR and ELISA tests should be used together for the early diagnosis of B19 infection in pregnant women.

show abstract

Section: Discussioncontrasting

confidence: 48%

Section: Discussionmentioning

confidence: 42%

Section: Discussionmentioning

confidence: 93%

See 1 more Smart Citation

The effects of Parvovirus B19 infection on pregnant women and fetus

Yarkın¹,

Şeflek²,

Sapmaz³

et al. 2017

J Immunol Clin Microbiol

View full text Add to dashboard Cite

show abstract

“…Parvovirus B19 also can be an important cause of intrauterine fetal death in the third trimester, and third trimester deaths are often not hydropic. 11 Intrauterine death should prompt a woman to consider undergoing serum evaluation for parvovirus antibodies as part of the evaluation of the fetus. 12 Tolfvenstam et al 11 reported that 15% of cases of intrauterine fetal death were positive for parvovirus B19 in fetal or placental tissues or both.…”

Section: Clinical Manifestationsmentioning

confidence: 99%

Hydrops Fetalis Secondary to Parvovirus B19 Infections

Raff²,

Muallem³

et al. 2003

The Journal of the American Board of Family Medicine

View full text Add to dashboard Cite

“…12 But it is reported that parvovirus B19 still can be a reason of fetal death in the third trimester and these fetal deaths are usually non-hydropic. 39 Sarfraz et al investigated 35 940 pregnant women in Norway and reported that, only four women had serological signs of acute parvovirus B19 infection in pregnancy, either presence of IgM antibodies in the first serum sample or seroconversion, among the 281 women who experienced fetal death. 40 Parvovirus B19 does not cause growth failure of the fetus.…”

Section: Outcomes Of Parvovirus B19 Infections In Pregnancymentioning

confidence: 99%