Frequency of Human Papilloma Virus Occurrence Among Pathological Changes of the Oral Cavity in Kidney Allotransplant Recipients Undergoing Long-Term Pharmacological Immunosuppressive Therapy

Szubińska-Lelonkiewicz, D.; Osiak, Martyna; Wychowański, Piotr; Siewert-Gutowska, M.; Fiedor, Piotr

doi:10.1016/j.transproceed.2018.05.008

Cited by 12 publications

(17 citation statements)

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“…However, those estimates were based on small numbers and were thus not statistically significantly different from our results. Furthermore, the study with the highest prevalence (36.1%) was conducted among RTRs with pathological changes in the oral cavity (Szubińska‐Lelonkiewicz et al, ). Differences in oral HPV prevalence across studies may be explained by several factors.…”

Section: Discussionmentioning

confidence: 99%

“…In comparison with our study, somewhat higher prevalences of oral prevalence across studies may be explained by several factors. Two studies used a brush to collect oral samples (Ammatuna et al, 2001;Rose et al, 2006), while in one study a biopsy was taken (Szubińska-Lelonkiewicz et al, 2018). In addition, samples were collected from different areas of the oral cavity such as the tonsils, buccal mucosa and tongue, or the entire oral cavity.…”

Section: Discussionmentioning

confidence: 99%

“…These differences may be partly explained by differences in HPV detection methods and variations in the number of specific genotypes tested and detected. Thus, one study tested for a broad range of both mucosal and cutaneous HPV types (Rose et al, 2006), one study used an assay designated to detect certain genotypes (Szubińska-Lelonkiewicz et al, 2018), and one study only identified HPV-positive samples as belonging to either the high-risk or low-risk group (Ammatuna et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

“…Only few studies have reported on oral HPV in RTRs (Ammatuna et al, 2001;Rose et al, 2006;Szubińska-Lelonkiewicz, Osiak, Wychowański, Siewert-Gutowska, & Fiedor, 2018), and these were limited by a low number of study participants or lack of a control group. Only one previous study examined risk factors for oral HPV among RTRs (Rose et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

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Prevalence, type distribution and risk factors for oral HPV in Danish renal transplant recipients

et al. 2019

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Objective To assess the prevalence and type distribution of oral human papillomavirus (HPV) among renal transplant recipients (RTRs) and healthy controls and to examine risk factors for oral HPV among RTRs. Materials and Methods During 2016‐2017 we recruited 250 RTRs and 250 controls. Oral samples were tested for HPV DNA with INNO‐LiPA HPV Genotyping Extra II. All participants answered a questionnaire on lifestyle and sexual behaviour, and characteristics of RTRs were obtained from medical files. We assessed prevalence and type distribution of oral HPV. Using logistic regression, the risk of oral HPV and risk factors for oral HPV among RTRs were estimated as odds ratios (OR) with 95% confidence intervals (CI). Results Overall, 30 RTRs (12.1%) and 26 controls (10.4%) were oral HPV positive (OR = 1.14; 95% CI: 0.64–2.05). Female RTRs tended to have a higher oral HPV prevalence than controls (OR = 1.73; 95% CI: 0.63–4.77), while no difference was observed among men. HPV51 was the commonest genotype. Sexual behaviour tended to be associated with oral HPV among RTRs. Conclusions There was no overall difference in oral HPV prevalence between RTRs and controls, but female RTRs tended to have a higher prevalence of oral HPV than controls.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Prevalence, type distribution and risk factors for oral HPV in Danish renal transplant recipients

et al. 2019

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“…of kidney allograft recipients within 2 years after transplantation, where 25% of recipients were positive on HPV-16 DNA sequence. More than half of the studied group were male recipients [25]. This shows that HPV infection creates risk for not only cervical cancer development in female recipients, but also for HPV associated oral cancer which could be developed in both male and female recipients.…”

Section: Allograft Rejection Casesmentioning

confidence: 83%

Importance of High-Risk Human Papillomavirus Infection Detection in Female Renal Transplant Recipients in the First Year after Transplatation

Cistjakovs¹,

Sultanova²,

Jermakova³

et al. 2018

Preprint

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OBJECTIVES: Most of human papilomavirus (HPV) infections are “cleared” by the immune system, however, in cases of immune system suppression infections could lead to development of malignancies. The aim of this study was to find out the frequency of HR-HPV infection in early period after renal transplantation in Latvian recipients receiving immunosuppressive therapy and to follow the progression of the infection up to one year. METHODS: 43 female renal recipients (median age of 48 IQR= 39-58) and 79 practically healthy female individuals (median age of 48 IQR= 42-57) as a control group were enrolled in this investigation. For the detection of HPV infection patients' samples (blood and vaginal swabs) where collected two weeks after transplantation with following collection of six months and one year. Different polymerase chain reactions for HR-HPV genomic sequences detection and commercial ELISA kit for detection of anti-HPV IgG antibodies were used. RESULTS: In this study we show that frequency rate of HR-HPV infection has increased by the one year after transplantation from early stage of immumosuppressive therapy (from 24% to 36%). Also increase of HR-HPV load was detected over the time, showing the highest median viral load at sixth month after transplantation. CONCLUSIONS: From the obtained data follows that it is very important to carefully monitor patients receiving immunosuppression therapy on progression of HR-HPV. In the case of this viral infection presence, immunosuppressive therapy must be attentively adjusted to avoid the HR-HPV infection rapid progression with the subsequent development of CIN or cervical cancer.

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Increased prevalences of head and neck cancers in patients with Sjögren's syndrome

Yang,

Cheng,

Chen

et al. 2023

Head & Neck

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ObjectiveThis study aimed to investigate prevalences of head and neck cancers in patients with and those without Sjögren's syndrome using a population‐based dataset.MethodsWe retrieved sampled patients from Taiwan's Longitudinal Health Insurance Database. This study included 38 930 patients with Sjögren's syndrome and 155 720 propensity‐score matched comparison patients without Sjögren's syndrome.ResultsChi‐squared tests revealed that there was a statistically significant difference in the prevalences of head and neck cancers between patients with Sjögren's syndrome and comparison patients (1.77% vs. 1.22%, p < 0.001). The odds ratio for head and neck cancers for patients with Sjögren's syndrome relative to the comparison group was 1.452 (95% CI = 1.325–1.592).ConclusionsOur study demonstrated that patients with Sjögren's syndrome face increased odds of head and neck cancers, encompassing several sites including the oral cavity, oropharynx, nasopharynx, and thyroid.

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Frequency of Human Papilloma Virus Occurrence Among Pathological Changes of the Oral Cavity in Kidney Allotransplant Recipients Undergoing Long-Term Pharmacological Immunosuppressive Therapy

Cited by 12 publications

References 11 publications

Prevalence, type distribution and risk factors for oral HPV in Danish renal transplant recipients

Prevalence, type distribution and risk factors for oral HPV in Danish renal transplant recipients

Importance of High-Risk Human Papillomavirus Infection Detection in Female Renal Transplant Recipients in the First Year after Transplatation

Increased prevalences of head and neck cancers in patients with Sjögren's syndrome

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