Frequency of HPV in oral cavity squamous cell carcinoma

Abreu, Priscila Marinho de; Có, Anna Clara Gregório; Azevedo, Pedro; Valle, Isabella Bittencourt do; Oliveira, Karine Gadioli; Gouvêa, Sônia Alves; Cordeiro-Silva, Melissa Freitas; Louro, Iuri Drummond; Podestá, José Roberto Vasconcelos de; Lenzi, Jeferson; Sena, Agenor; Mendonça, Elismauro Francisco; Zeidler, Sandra Ventorin von

doi:10.1186/s12885-018-4247-3

Cited by 52 publications

(62 citation statements)

References 42 publications

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“…Most of the publications in which the intensity of macrophage infiltration within head and neck tumours was analysed concerned locations in the oral cavity [30] or other locations outside the oropharynx [31], where HR-HPV status was unknown. Due to the low frequency of HR-HPV infections in the 2.5-4% range in these anatomical sites, it can be assumed that the results presented in them relate mainly to the HPV-negative population [32][33][34].…”

Section: Discussion/conclusionmentioning

confidence: 99%

Infiltrates of M2-Like Tumour-Associated Macrophages Are Adverse Prognostic Factor in Patients with Human Papillomavirus-Negative but Not in Human Papillomavirus-Positive Oropharyngeal Squamous Cell Carcinoma

et al. 2020

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Introduction: Human papillomavirus with a high oncogenic potential (HR-HPV) is responsible for more than a half of squamous cell carcinomas of the oropharynx. The HR-HPVdependent cases of this tumour have a better prognosis compared to the HR-HPV-negative cases, despite the usually more advanced disease at the time of diagnosis. In addition to genetic and epigenetic factors, the causes of this more favourable course of the disease are also seen in the participation of the tumour microenvironment, including the patient's immune system. Macrophages are one of the most important elements of the immunocompetent cells landscape that make up the tumour microenvironment. Traditionally, they are divided into 2 groups: inflammatory macrophages with the M1 phenotype and tumour-associated macrophages known as M2 phenotype macrophages. Objective: The aim of this study was to investigate the impact ated with higher rate of nodal failures and a shorter nodal control in both HR-HPV groups. In the group of HR-HPV-negative patients, heavy infiltration of CD163 + macrophages was associated with significantly shorter: loco-regional control (LRC), metastasis-free survival and overall survival (OS). These parameters and prognosis in patients with scanty CD163 + infiltration were similar to favourable outcomes in HR-HPV-positive patients. The relative risk of local-regional recurrence, distant metastases and disease-related death in HR-HPV-negative patients with intense CD163 + infiltrates was, respectively, 4.7, 5.4 and 5.7 compared to patients with scanty infiltrates. Conclusions: Tumours with a positive HR-HPV status demonstrate intense infiltrations of total pool M1/M2 and M2 macrophages. In the group of HPV-negative patients, intensive M1/M2 macrophage infiltrates correlate with higher risk of nodal failures, and intensive M2 infiltrates are an adverse prognostic factor for LRC, metastasis-free survival and OS.

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Section: Discussion/conclusionmentioning

confidence: 99%

Infiltrates of M2-Like Tumour-Associated Macrophages Are Adverse Prognostic Factor in Patients with Human Papillomavirus-Negative but Not in Human Papillomavirus-Positive Oropharyngeal Squamous Cell Carcinoma

et al. 2020

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“…3 The reported prevalence of HPV in oral squamous cell carcinoma (OSCC) varies from 4% to 95%. [4][5][6][7][8][9] A meta-analysis indicated a mean HPV prevalence of 30.1%, but there was marked variability in the cohorts and HPV testing regimen. 10,11 Recent series, with robust methods of detection, have indicated that the true incidence of HPV in OSCC is probably rather low, perhaps of the order of 5%.…”

Section: Introductionmentioning

confidence: 99%

Human papillomavirus (HPV) can establish productive infection in dysplastic oral mucosa, but HPV status is poorly predicted by histological features and p16 expression

et al. 2020

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Aims Previous studies have reported the presence of high‐risk human papillomavirus (HR‐HPV) in a subset of dysplastic oral epithelial lesions. Many cases show a histological spectrum of atypia similar to that seen in non‐human papillomavirus (HPV) severe epithelial dysplasia, but some studies have suggested that HPV status can be inferred on the basis of histological features. We aimed to assess the utility of such histological features and p16 as surrogate markers of HPV infection in a retrospective cohort of 33 cases of severe epithelial dysplasia, with matched clinicopathological data and histological features. Methods and results Tissue sections were assessed for the expression of p16, minichromosome maintenance 2, HPV E4 and HPV L1 by the use of immunohistochemistry. HPV16/18 E6 and E7 expression was assessed by the use of RNA in‐situ hybridisation (RNAScope). In the cohort, 18.2% of cases (6/33) were HR‐HPV‐positive, with no age/gender differences between the HPV‐positive and HPV‐negative groups. HPV E4 and HPV L1 were expressed in surface keratinocytes in four of six (66%) HPV‐positive cases, indicative of productive HPV infection. Lack of p16 expression was predictive of HPV‐negative status, but sensitivity and specificity varied according to the cut‐off. Histologically, the presence of karyorrhectic nuclei and abnormal mitotic figures was higher in HPV‐positive lesions (P < 0.05), but the predictive specificity and sensitivity were suboptimal (sensitivity, 0.75; specificity, 0.52). Conclusions This study demonstrates, for the first time, that a minority of severely dysplastic oral lesions harbour productive, biologically relevant HPV infection. Consideration should be given to the specific assessment of HPV status in severe epithelial dysplasia cases, as both p16 status and the presence of karyorrhectic cells are poor predictive markers of HPV status.

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“…HPV16 has been commonly reported in cases with HPV‐positive head and neck cancer and is frequently associated with oral cancer lesions in north Indian populations . The less‐frequent high‐risk HPV types comprise HPV18, HPV33, HPV35, HPV45, and HPV59 . In contrast, there was a report showing that the probability of cancer in the oral cavity, larynx, and hypopharynx being attributable to HPV was at least fivefold lower than that for oropharyngeal cancer .…”

Section: Introductionmentioning

confidence: 99%

“…12 The less-frequent high-risk HPV types comprise HPV18, HPV33, HPV35, HPV45, and HPV59. 9,10 In contrast, there was a report showing that the probability of cancer in the oral cavity, larynx, and hypopharynx being attributable to HPV was at least fivefold lower than that for oropharyngeal cancer. 13 The role of HPV in the etiology of SCC of oral cavity remains to be established.…”

mentioning

confidence: 97%

“…8 The symptoms of early OSCC, precancer, and non-cancer lesions cannot be differentiated visually and requires histopathological investigation for the diagnosis of lesions. HPV16 has been commonly reported in cases with HPV-positive head and neck cancer [9][10][11] and is frequently associated with oral cancer lesions in north Indian populations. 12 The less-frequent high-risk HPV types comprise HPV18, HPV33, HPV35, HPV45, and HPV59.…”

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confidence: 99%

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Prevalence of human papillomavirus type 16 in persistent oral lesions arising in patients with tobacco, areca nut, and alcohol habits

Khowal

Jain

Wajid

2019

Oral Science International

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Background and purpose Human papillomavirus (HPV) has been shown to be associated with oral malignancies. The purpose of this study was to detect HPV and a high‐risk type HPV16 viral DNA in 24 cases with oral squamous cell carcinoma (OSCC) and 15 cases with non‐OSCC persistent oral lesions (POL) residing in North India. The diagnosis was determined by the histopathological characteristics of the oral biopsy. Results All oral lesions were HPV‐DNA positive, and the HPV16‐positive ratios of OSCC and non‐OSCC POLs were 50% and 53%, respectively. Approximately 62% of moderately differentiated OSCC and 36% of well‐differentiated OSCC were HPV16 positive. Evaluated odds and prevalence ratios >1 indicated a higher prevalence of HPV16 infection in patients with tobacco, areca nut, and/or alcohol habits, compared with nonaddicts. The obtained P‐values were higher than 0.05, indicating that the relationship is statistically insignificant, which may be due to lower number of POL cases. This study could not conclude that HPV16 infection plays an essential role in malignant transformation of the oral mucosa, raising a need for further experimental endeavors. Conclusions This study indicates that HPV16 infection in OSCC and non‐OSCC POLs frequently occurred in people with tobacco smoking, tobacco‐areca nut chewing, and alcohol intake. These fallacious habits may increase HPV16 infection in the oral cavity.

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Frequency of HPV in oral cavity squamous cell carcinoma

Cited by 52 publications

References 42 publications

Infiltrates of M2-Like Tumour-Associated Macrophages Are Adverse Prognostic Factor in Patients with Human Papillomavirus-Negative but Not in Human Papillomavirus-Positive Oropharyngeal Squamous Cell Carcinoma

Infiltrates of M2-Like Tumour-Associated Macrophages Are Adverse Prognostic Factor in Patients with Human Papillomavirus-Negative but Not in Human Papillomavirus-Positive Oropharyngeal Squamous Cell Carcinoma

Human papillomavirus (HPV) can establish productive infection in dysplastic oral mucosa, but HPV status is poorly predicted by histological features and p16 expression

Prevalence of human papillomavirus type 16 in persistent oral lesions arising in patients with tobacco, areca nut, and alcohol habits

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