Frequency of Hashimoto's thyroiditis in children with type 1 diabetes mellitus

Radetti, Giorgio; Paganini, Chiara; Gentili, Lino; Bernasconi, Sergio; Betterle, Corrado; Borkenstein, M; Cvijović, Katarina; Kadrnka-Lovrencić, M; Kržišnik, Ciril; Battelino, Tadej; Lorini, Renata; Marinoni, S; Rigon, F.; Tatò, Luciano; Pinelli, Leonardo; Tonini, G.

doi:10.1007/bf00569570

Cited by 79 publications

(55 citation statements)

References 12 publications

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“…AITD with the presence of anti-TPO have been well described in pediatric patients. The literature confirms a high AITD prevalence in young adults with DM 1, with a predominance of females in this group [6].…”

supporting

confidence: 67%

Prevalence of Anti-Thyroid Peroxidase in Adults with Type 1 Diabetes Participating in Poznań Prospective Study

et al. 2015

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Background. Type 1 diabetes (DM 1) is frequently associated with autoimmune thyroid diseases (AITD). Screening for AITD in adults is rarely performed. The aim of this study was to evaluate the prevalence of anti-thyroid peroxidase (anti-TPO) and thyroid function and their association with metabolic control in adults participating in Poznan Prospective Study (PoProStu). Material and Methods. The analysis included 74 patients (26 women and 48 men) aged 38.5 (IQR: 34.5-42.5), who have had diabetes for 15.0 (14-16) years. All patients have been treated with intensive functional insulin therapy (IFIT) from the onset of the disease. Anti-TPO and thyroid-stimulating hormone (TSH) were determined. The concentration of anti-TPO ≥ 5.61 IU/mL was considered positive. Based on the levels of anti-TPO the patients were divided into two groups: anti-TPO positive and anti-TPO negative. Metabolic control was assessed by the level of glycated hemoglobin (HbA 1c ). Results. Anti-TPO was positive in 32 (43.2%) patients. Prevalence of autoantibodies was significantly higher in women (53% vs 21%; p = 0.009). There was no significant difference in HbA 1c levels [median (IQR): 7.6% (7.1-8.6) vs 7.6% (7.1-8.8); p = 0.82] and TSH levels [median (IQR): 2.05 µIU/mL (1.23-3.15) vs 1.62 µIU/mL (1.00-2.10); p = 0.06] between anti-TPO positive and negative patients. After excluding patients with a thyroid dysfunction, a significant difference in TSH levels between anti-TPO positive and negative group was found [median (IQR): 2.11 µIU/mL (1.29-3.31) vs 1.66 µIU/mL (1.29-3.31); p = 0.04]. Conclusions. High anti-TPO prevalence is found in adult patients with long-standing DM 1, and autoantibodies occur more often in women. Therefore, screening for asymptomatic thyroid dysfunction should be performed in this group, as already recommended by the joint statement of Polish Society of Endocrinology and Diabetes Poland (Adv Clin Exp Med 2015, 24, 1, 79-84).

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supporting

confidence: 67%

Prevalence of Anti-Thyroid Peroxidase in Adults with Type 1 Diabetes Participating in Poznań Prospective Study

et al. 2015

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“…The recent extensive Ab screening study in patients with T1DM has raised awareness of the association of T1DM with organ-specific autoimmunity [29]. The reported prevalence of thyroid autoimmunity in young T1DM patients ranges between 3% and 50% [10,[30][31][32][33], while it is 3.4%-7% in the general paediatric population [34,35]. The association of T1DM and AITD is highly dependent on age, sex and ethnicity [36].…”

Section: Discussionmentioning

confidence: 99%

Organ-specific autoimmunity in relation to clinical characteristics in children with long-lasting type 1 diabetes

Głowińska‐Olszewska

Michalak

Łuczyński

et al. 2016

Journal of Pediatric Endocrinology and Metabolism

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Background: The aim of this study was to assess the prevalence of diabetes and other organ-specific autoantibodies (Ab) associated with various autoimmune conditions, in Polish children with type 1 diabetes mellitus (T1DM). Methods: In this study 114 patients, aged 13.4 years, with mean diabetes duration 5.2 years were included. Ab to islet cell antigens: glutamic acid decarboxylase (GAD), insulinoma antigen 2 (IA-2), zinc transporter 8 (ZnT8), together with thyroid peroxidase Ab (TPO Ab), thyroglobulin Ab (Tg Ab), tissue transglutaminase Ab (tTG Ab) and 21-hydroxylase Ab (21-OH Ab) were measured. Results: The prevalence of at least one diabetes associated Ab was found in 87%, with the highest prevalence of 64% for ZnT8 Ab. In patients with disease duration < 5 years, at least one antibody was present in 90%, the most prevalent was ZnT8 Ab (72%). In patients with duration > 10 years, 50% had at least one antibody. The prevalence of other than islet cell autoimmunity was high (34%). Thyroid Ab were detected in 26% patients, 42% in girls vs. 8% in boys, p < 0.001. tTG Ab were found in 11% patients, with a greater prevalence in children with early onset (p = 0.01). 21-OH Ab were found in 2.6% T1DM patients.

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“…In children with type 1 diabetes, the reported prevalence of autoimmune thyroiditis is 4% [41] and that of associated thyroid antibodies (thyroid peroxidase [TPO] antibodies, thyroglobulin [TG] antibodies) 16% [42]. Approximately 25% of adults with autoimmune diabetes have serological evidence of autoimmune thyroiditis.…”

Section: Autoimmune Disease Associationsmentioning

confidence: 99%

Latent autoimmune diabetes in adults (LADA) should be less latent

et al. 2005

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'Latent autoimmune diabetes in adults' (LADA) is the term coined to describe adults who have a slowly progressive form of autoimmune or type 1 diabetes that can be treated initially without insulin injections. The diagnosis of LADA is currently based on three clinical criteria: (1) adult age at onset of diabetes; (2) the presence of circulating islet autoantibodies, which distinguishes LADA from type 2 diabetes; and (3) insulin independence at diagnosis, which distinguishes LADA from classic type 1 diabetes. The prevalence of LADA in adults presenting with non-insulin-requiring diabetes is approximately 10%. Recognition of LADA expands the concept and prevalence of autoimmune diabetes, but LADA remains poorly understood at both a clinical and research level. In this perspective, we review the nomenclature, diagnostic criteria, genetics, pathology and therapy of LADA, to arrive at recommendations that might advance knowledge and management of this form of diabetes.

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Frequency of Hashimoto's thyroiditis in children with type 1 diabetes mellitus

Cited by 79 publications

References 12 publications

Prevalence of Anti-Thyroid Peroxidase in Adults with Type 1 Diabetes Participating in Poznań Prospective Study

Prevalence of Anti-Thyroid Peroxidase in Adults with Type 1 Diabetes Participating in Poznań Prospective Study

Organ-specific autoimmunity in relation to clinical characteristics in children with long-lasting type 1 diabetes

Latent autoimmune diabetes in adults (LADA) should be less latent

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