Frequency of gestational malaria and maternal–neonatal outcomes, in Northwestern Colombia 2009–2020

Cardona‐Arias, Jaiberth Antonio; Carmona‐Fonseca, Jaime

doi:10.1038/s41598-022-15011-1

Cited by 4 publications

(7 citation statements)

References 36 publications

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“…Penelitian sebelumnya melaporkan outcome dari kehamilan dengan infeksi malaria paling banyak adalah anemia (32,1%), abortus (15,5%), neonatal malaria (15,5%), berat badan lahir rendah (6,5%), lahir mati (2,5%), dan kematian janin (1%). 10 Banyaknya dampak buruk akibat infeksi malaria selama kehamilan, maka perlu adanya perhatian khusus untuk mencegah dan mengurangi prevalensi malaria pada ibu hamil. Masih kurangnya informasi terkait patobiologi terkait infeksi malaria pada ibu hamil yang menyebabkan strategi pencegahan dan terapi belum optimal.…”

Section: Pendahuluanunclassified

“…Beberapa hasil penelitian menunjukkan bahwa ibu hamil dengan infeksi malaria lebih berisiko untuk terjadinya kelahiran prematur, anemia berat, kematian janin dalam rahim, dan keguguran. 10,22 Dampak lainnya terhadap bayi diantaranya BBLR, lahir mati, dan kematian neonatus. 22,23…”

Section: Dampak Infeksi Malaria Pada Maternal Dan Neonatalunclassified

“…Salah satu artikel mengungkapkan bahwa anemia pada wanita hamil dengan infeksi malaria 87% lebih tinggi dibandingkan pada wanita hamil yang tidak terinfeksi malaria. 10 Prevalensi anemia pada ibu hamil yang terinfeksi malaria paling banyak terjadi pada kehamilan trimester 3 sebanyak 58%. 15 Hasil systematic review lainnya mengungkapkan bahwa wanita hamil yang terinfeksi malaria dua kali lebih mungkin untuk mengalami anemia yang berlanjut pada kehamilannya.…”

Section: A Maternal Anemiaunclassified

“…Ibu hamil yang mengalami infeksi malaria memiliki kemungkinan lebih besar untuk mengalami kelahiran prematur dan besar risiko untuk bayi lahir dengan BBLR. 6,10,13,15,16,17 Ibu hamil dengan infeksi malaria akan memiliki kemungkinan yang sama besar untuk mengalami kelahiran di usia yang belum mature dengan berat badan yang kurang dari ideal (<2500 gram) 12 . Hasil tersebut berhubungan dengan parasite malaria yang dapat menginfeksi plasenta selama periode infeksi malaria pada ibu hamil 6 .…”

Section: Kelahiran Prematur Dan Bblrunclassified

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Systematic Review: Prevalensi dan Dampak Infeksi Malaria pada Wanita Hamil dan Neonatal

Purwatiningsih¹,

Lestyoningrum²,

Sunaryo³

et al. 2023

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Globally, malaria cases in the world reached 241 million cases in 2020 and increase from the previous year. Malaria infection in pregnant women was reported in 33 countries, and the cases were estimated at 11.6 million (34%). Malaria infection can increase maternal and fetal morbidity and mortality, including anemia in pregnancy, low birth weight, premature birth, stillbirth, and small gestation age, and congenital malaria. This article discusses pregnant women's malaria infection prevalence and maternal and neonatal outcomes. This paper is a systematic review by searching for articles using electronic databases from Pubmed and ScienceDirect using keywords “Malaria” and “Pregnancy” or “Pregnant Women” and “Outcome” or “Impact” and “Maternal” or “Neonatal”. The selection of articles used the PRISMA guidelines which were then analyzed in a narrative manner. Based on the article search results obtained 10 articles that meet the criteria for analysis. The prevalence of malaria infection in pregnancy is still high. Reported outcomes in pregnancy, birth, and neonates include preterm birth, low birth weight, small gestation age, maternal anemia, and maternal and neonatal mortality. The role of health workers is very important to prevent malaria infection in pregnancy so that it does not result in adverse health impacts for maternal and neonatal.

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Section: Pendahuluanunclassified

Section: Dampak Infeksi Malaria Pada Maternal Dan Neonatalunclassified

Section: A Maternal Anemiaunclassified

Section: Kelahiran Prematur Dan Bblrunclassified

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Systematic Review: Prevalensi dan Dampak Infeksi Malaria pada Wanita Hamil dan Neonatal

Purwatiningsih¹,

Lestyoningrum²,

Sunaryo³

et al. 2023

blb

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“…A meta-analysis reported a prevalence of 16.7% (95% confidence interval [CI], 9.0–28.8) for GM, 11.0% (95% CI, 4.1–26.3) PM, and 16.2% (95% CI, 8.2–29.5) CM [ 13 ]. Another study found 35.8% GM, associated with maternal anemia, CM, and lower birth weight [ 14 ]. A study reported PM 27.7%, associated with CM, lower neonatal weight, and maternal anemia [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Accuracy of a Thick Blood Smear Compared to qPCR for Malaria Associated with Pregnancy in Colombia

2023

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This study aimed to evaluate the accuracy of the thick blood smear (TBS) versus quantitative polymerase chain reaction (qPCR) for the diagnosis of malaria associated with pregnancy (MAP) caused by P. falciparum or P. vivax in Colombia in its gestational malaria (GM), placental malaria (PM), and congenital malaria (CM) forms as well as to compare its accuracy in different subgroups of pregnant women according to the presence of fever, anemia and a history of malaria. This was a diagnostic evaluation of 829 pregnant women, 579 placentas, 381 umbilical cord samples, and 221 neonatal peripheral blood samples. Accuracy was evaluated based on the parameters of sensitivity, specificity, predictive values, likelihood ratios, and validity index, with their 95% confidence intervals. The frequency of GM was 36% (n = 297/829), PM 27% (n = 159/579), and CM 16.5% (n = 63/381) in umbilical cord samples and 2% (n = 5/221) in neonatal peripheral blood samples. For GM, the sensitivity was 55%, with higher rates in those infected with P. vivax (68%), with a history of malaria (69%), and with fever (96%). These three subgroups presented the best results in terms of the negative likelihood ratio and validity index. For PM, sensitivity was 8%; in subgroup analyses in terms of species, symptomatology (anemia and fever), and history of malaria, it was 1–18%, and the negative likelihood ratio was >0.80 in all subgroups. No false positives were recorded in any of the subgroups. The TBS did not detect any cases of CM. This study found the TBS yielded satisfactory results in terms of diagnosing GM for P. vivax, pregnant women with previous malaria and febrile. It also showed that the TBS is not useful for diagnosing PM and CM. It is necessary to conduct surveillance of MAP with molecular methods in in groups where TBS is deficient (asymptomatic GM, P. falciparum, and pregnant women without history of malaria) to optimize the timely treatment of PM and CM, avoid the deleterious effects of MAP and achieve the malaria elimination goals in Colombia.

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Clinical and Parasitological Profiles of Gestational, Placental and Congenital Malaria in Northwestern Colombia

2023

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This study compared the clinical–parasitological profiles of gestational (GM), placental (PM), and congenital (CM) malaria in northwestern Colombia. A cross-sectional study with 829 pregnant women, 549 placentas, and 547 newborns was conducted. The frequency of GM was 35.8%, PM 20.9%, and CM 8.5%. P. vivax predominated in GM; in PM, the proportion of P. vivax and P. falciparum was similar; in CM, P. falciparum predominated. The main clinical findings were headache (49%), anemia (32%), fever (24%), and musculoskeletal pain (13%). The clinical manifestations were statistically higher in P. vivax infections. In submicroscopic GM (positive with qPCR and negative with thick blood smear), the frequency of anemia, sore throat, and a headache was statistically higher compared with pregnant women without malaria. GM, PM, and CM reduce birth weight and head circumference. In Colombia, this is the first research on the clinical characteristics of GM, PM, and CM; contrary to evidence from other countries, P. vivax and submicroscopic infections are associated with clinical outcomes.

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Frequency of gestational malaria and maternal–neonatal outcomes, in Northwestern Colombia 2009–2020

Cited by 4 publications

References 36 publications

Systematic Review: Prevalensi dan Dampak Infeksi Malaria pada Wanita Hamil dan Neonatal

Systematic Review: Prevalensi dan Dampak Infeksi Malaria pada Wanita Hamil dan Neonatal

Diagnostic Accuracy of a Thick Blood Smear Compared to qPCR for Malaria Associated with Pregnancy in Colombia

Clinical and Parasitological Profiles of Gestational, Placental and Congenital Malaria in Northwestern Colombia

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