Frequency of gastroesophageal reflux disease in adolescent girls with anorexia nervosa

Smolińska, Katarzyna; Dziekiewicz, Marcin; Liber, Anna; Banasiuk, Marcin; Wolańczyk, Tomasz; Szymańska, Urszula; Banaszkiewicz, Aleksandra

doi:10.12740/pp/onlinefirst/118269

Cited by 2 publications

(1 citation statement)

References 14 publications

(17 reference statements)

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“…In Asia, heartburn or reflux is diagnosed at least once a week, and then the endoscopic presentation of the esophagus is divided into three types: reflux esophagitis, non-erosive reflux disease and Barrett’s esophagitis [ 5 ]. The prevalence of GERD is increasing year by year, as shown by the recent publications [ 6 , 7 ]. The pathogenesis of GERD is complex, and current treatment is based on the use of proton pump inhibitors to promote esophageal mucosal healing and gastrointestinal motility drugs to increase lower esophageal sphincter (LES) pressure [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of tegoprazan in the treatment of gastroesophageal reflux disease: A protocol for meta-analysis and systematic review

Zheng,

Yuan,

Liu

2024

PLoS ONE

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Objective The incidence of gastroesophageal reflux disease (GERD) is increasing year by year, the clinical manifestations are complex and diverse, and the adverse effects of long-term use of proton pump inhibitors and gastrointestinal motility drugs have been of great concern in recent years. The effectiveness of tegoprazan in the treatment of GERD is still controversial. This protocol describes a systematic review and meta-analysis to evaluate the efficacy and safety of tegoprazan in the treatment of gastroesophageal reflux disease. Methods PubMed, Embase, Cochrane Library and Web of Science will be searched from the database inception to 1 March 2023. All randomized controlled trials related to tegoprazan for GERD will be included. Extracted data will include publication details, basic information, demographic data, intervention details and patient outcomes. The primary outcome will be complete resolution of major symptoms, complete resolution of heartburn, proportion of heartburn-free days, chronic cough, hoarseness, and adverse events. Risk of bias will be assessed using the Cochrane Collaboration’s tool for assessing risk of bias. Article selection, data extraction and risk of bias assessment will be performed in duplicate by two independent reviewers. If the meta-analysis is precluded, we will conduct a descriptive synthesis using a best-evidence synthesis approach. Discussion The results of this study will provide reliable evidence to evaluate the efficacy and safety of tegoprazan in the treatment of GERD and help patients, physicians and clinical investigators choose the most appropriate treatment.

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Section: Introductionmentioning

confidence: 99%

Efficacy and safety of tegoprazan in the treatment of gastroesophageal reflux disease: A protocol for meta-analysis and systematic review

Zheng,

Yuan,

Liu

2024

PLoS ONE

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Unveiling vocal profiles in adolescent anorexia nervosa: a Software Based, Multiparametric Analysis

Pruccoli,

di Torrepadula,

Bergonzini

et al. 2024

Eur Child Adolesc Psychiatry

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Dysphonia, characterized by disturbances in voice quality and modulation, has been sporadically observed in individuals with Anorexia Nervosa (AN), potentially stemming from both organic and psychopathological factors. This study seeks to employ software-based voice analysis to compare the voices of girls with AN to those of female healthy controls (HC). Case-control study adopting “Praat” software to assess voices. Various parameters, including Acoustic Voice Quality Index (AVQI), Fundamental Frequency (F0), Yanagihara’s Spectrographic Dysphonia Classifications, and “GIRBAS” perceptual qualitative voice rating, were investigated. Participants completed questionnaires for Vocal Fatigue Index (VFI) and the Reflux Symptoms Index (RSI). Puberty-related voice spectrum changes were considered, and Bonferroni-corrected BMI-adjusted Analyses of Covariance (ANCOVAs) were conducted. The study enrolled 15 girls with AN and 23 girls with HC. AN patients demonstrated greater impairment in voice tiredness/voice avoidance (VFI-1, p < 0.001), vocal physical discomfort (VIF-2, p = 0.002), and rest as alleviation (VFI-3, p = 0.012). Reflux-related scores were higher in AN (p < 0.001). Differences were observed in voice quality (AVQI) (p = 0.001), and GIRBAS scales showed alterations in multiple parameters. Spectrograms documented more frequent pathological findings in AN patients (p = 0.021). No difference was observed in Fundamental Frequency. These group (AN/HC) differences were independent of weight measures. This study is the first to connect voice irregularities in AN by employing standardized, non-invasive tools and accounting for weight-related factors. Young AN patients demonstrated substantial voice quality changes and heightened self-reported symptoms. Future research should expand on these findings with prospective designs and invasive investigations.

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Frequency of gastroesophageal reflux disease in adolescent girls with anorexia nervosa

Cited by 2 publications

References 14 publications

Efficacy and safety of tegoprazan in the treatment of gastroesophageal reflux disease: A protocol for meta-analysis and systematic review

Efficacy and safety of tegoprazan in the treatment of gastroesophageal reflux disease: A protocol for meta-analysis and systematic review

Unveiling vocal profiles in adolescent anorexia nervosa: a Software Based, Multiparametric Analysis

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